Keshore Bidasee, Ph.D.

Associate ProfessorKeshore Bidasee

Durham Research Center 3047
985800 Nebraska Medical Center
Omaha, NE 68198-5800

Phone: 402-559-9018
E-mail: Keshore Bidasee

Keywords: Diabetes, heart, muscle contraction, calcium cycling proteins ryanodine receptors, Ca2+-ATPase, myosin heavy chain, echocardiography, calcium transients

In the News
Professional Summary
Research Interests
Representative Publications
Dr. Bidasee's biographical information
Visit Dr. Bidasee's laboratory

In the News:

Dr. Bidasee honored for Most Promising New Invention by UNeMed.

YouTubeDr. Bidasee in his own words.

Professional Summary:

Not only will our research lead to improvements in the quality of life for diabetic patients but also help control the escalating economic cost medical expenditure and loss productivity, which was estimated at $150 billion annually. 

Research Interests:

Our long term goals are to better understand (i) molecular and cellular mechanisms responsible for cardiovascular complications in individuals with diabetes mellitus (DM), and (ii) to identify therapeutic strategies that could be used to slow their progressions.

In spite of an armamentarium of glucose-lowering agents, glucose monitoring devices, food management, and exercise strategies, individuals with DM are continuing to develop cardiovascular diseases at rates 3-4 times higher than that of the general population.  There are also no specific pharmacological agents available to prevent the development of these cardiovascular diseases.  

Reactive carbonyl species (RCS) are small mono- and di-carbonyl molecules generated from glucose and lipid metabolisms.  These electrophilic molecules play important roles in regulating key physiologic functions including growth, differentiation, proliferation, and apoptosis and their cellular levels are tightly regulated to minimize undesired effects.  In individuals with DM cellular levels of “free” RCS increases. When unregulated, RCS irreversibly react with susceptible basic amino acid residues on proteins to alter their functions. They also perturb cellular Ca2+ homeostasis, increase production of pro-inflammatory mediators and oxidative stress form adducts with DNA.

A better understanding of how to regulate RCS levels in diabetes could help alleviate cardiovascular complications in diabetes.

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Representative Publications:

  1. Moore CJ, Shao CH, Nagai R, Kutty S Singh J and Bidasee KR.  Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2) in diabetes.  Mol Cell Biochem. 376(1-2):121-35, 2013. PMID 23354458
  2. Shao C-H, Tian C, Ouyang S, Moore CJ, Alomar F, Nemet I, D’Souza A, Nagai R, Kutty S, Rozanski  GJ, Ramanadham S, Singh J and Bidasee KR. Cabonylation induces heterogeneity in cardiac  ryanodine receptor function during diabetes. Mol Pharmacol 82: 383-399, 2012. PMID 22648972
  3. Shao CH, Capek HL, Patel KP, Wang M, Tang K, Desouza C, Nagai R, Mayhan W, Periasamy M, Bidasee KR.  Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of Type 1 diabetes. Diabetes 60:947-959, 2011. PMID 21300842
  4. Tian C, Shao CH, Moore CJ, Kutty S, Walseth T, DeSouza C, Bidasee KR. Gain-of-function of cardiac ryanodine receptor in a rat model of type 1 diabetes. Cardiovasc Res 91: 300-309, 2011. PMID 21421556
  5. Desouza CV, Hamel FG, Bidasee KR, O'Connell K. Role of inflammation and insulin resistance in endothelial progenitor cell dysfunction. Diabetes 60: 1286-1294, 2011. PMID 21346178
  6. Shao CH, Rozanski GJ, Nagai R, Stockdale FE, Patel KP, Wang M, Singh J, Mayhan WG, Bidasee KR. Carbonylation of myosin heavy chains in rat heart during diabetes. Biochem Pharmacol. 2010;80(2):205-17. PMID 20359464

Work in our lab has been funded by the National Institutes of Health.

Additional publications in PubMed.

Dr. Bidasee's biographical information
Visit Dr. Bidasee's laboratory
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