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Collaborators

Aftab Ansari, Eric Hunter, and Paul Spearman, (Emory University)
Francois Villinger (New Iberia Research Center, University of Louisiana, Lafayette)
Richard Cummings (Harvard University)
James Arthos and Claudia Cicala (NIH)
Michael Barry (Mayo Clinic)
Nebraska Food for Health Center at the University of Nebraska
Shilpa Buch, Howard Fox, Courtney Fletcher and Howard E. Gendelman (UNMC)
Pooja Jain (Drexel University)
Philipa Santangelo (Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech, Atlanta)
Ranga Uday Kumar, Molecular Biology & Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (http://www.jncasr.ac.in/udaykumar/Page441.htm)
Mirko Paiardini, Emory University (http://vaccines.emory.edu/faculty-evc/primary-faculty/paiardini_mirko.html)
Mahesh Mohan, Tulane University (https://www2.tulane.edu/tnprc/faculty/mahesh-mohan.cfm)

Funding

Limiting HIV establishment and maintenance by preserving intestinal immunity
MPI: Byrareddy/Paiardini
NIH/NIAID R01AI129474-01A1
In this project we will explore the therapeutic potential of a combined interleukin (IL)-21 and anti-α4β7 Ab intervention to reduce gut damage and immune activation, improve antiviral responses, and limit the size of the reservoir in ART-treated, SIV-infected rhesus macaques.

Role of HIV Env glycosylation in mucosal transmission
PI: Byrareddy, S.
NIH/NIAID R01 AI113883
This project will aim investigate and compare glycosylation patterns between linked transmission and founder viruses from recently transmitting couples in /Africa and test in a nonhuman primate model whether glycosylation is a major determinant in the ability of a virus to transmit across the mucosal surface.

Chronic HIV Infection and Aging in NeuroAIDS (CHAIN) Center
MPI: Buch, S. and Fox, H.; Cell-Tissue-Animal Core Leader: Byrareddy, S.
NIH/NIMH P30MH062261
This is a Center grant to provide Administrative and Core Support for scientists investigating NeuroAIDS.

The brain as a SIV reservoir under suppressive cART potentiation by drugs of abuse
MPI: Fox H./Byrareddy S./Buch S.
R01DA043164-01
Using the SIV/macaque system, we will determine whether the brain is a viral reservoir in the setting of effective treatment.

The combinatorial effects of opiates and the emerging promoter-variant strains of HIV-1 subtype C on HIV neuropathogensis and latency
MPI: Buch S/Byrareddy S/Fox H.
R01DA041751-01
In this proposal, we plan to investigate the involvement of the combinatorial effects of opiates and the emerging promoter-variant strains of HIV-1 subtype C on HIV neuropathogenesis and latency and  to test this hypothesis in a primate model.

Targeting gut-brain axis to eliminate CNS reservoirs
PI: Byrareddy S.
R21 MH113455-01
In this project, we will aim at modifying immune cell targeting to reduce the accumulation of infected cells in the both the gut and CNS using monkey as model.

Molecular mechanisms underlying Zika virus mediated neuropathogenesis
Nebraska Neuroscience Alliance Endowed Fund
MPI: Byrareddy S. and Gorantla, S.

Extracellular vesicle driven communications in CNS of HIV-infected opiate abusers
Nebraska Center for Substance Abuse Research
MPI: Dave R., Byrareddy S., Hu, G. 

Personnel

Rajnish Dave Instructor Research Interests: HIV/SIV neuropathogenesis and neuroAIDS, substance abuse
Debashis Dutta Post Doc Research Associate Research Interests: Molecular biology, microbiology, immunology
Rye Jaffe Graduate Research Assistant - Intern
Samuel D. Johnson Graduate Research Assistant
Lindsey Knight Research Technologist I
Lepakshe S V Madduri Research Technologist I
Santanu Mukherjee Post Doc Research Associate Research interests:  glycosylation; neuroAIDS; mucosal transmission
Omalla A. Olwenyi Graduate Research Assistant
Kabita Pandey Research Technologist
Nanda Kishore Routhu Post Doc Research Associate Research Interests: Zika virus (ZIKV) pathogenesis mechanisms, HIV/SIV/SHIV, neuroAIDS
Srijayaprakash Uppada Post Doc Research Associate Research Interests: Mucositis; signaling mechanism; immunotherapy

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