Dr. Byrareddy's Laboratory

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Lab Phone: 402-559-3028

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Collaborators

Aftab Ansari, Eric Hunter, and Paul Spearman, (Emory University)
Francois Villinger (New Iberia Research Center, University of Louisiana, Lafayette)
Richard Cummings (Harvard University)
James Arthos and Claudia Cicala (NIH)
Michael Barry (Mayo Clinic)
Nebraska Food for Health Center at the University of Nebraska
Shilpa Buch, Howard Fox, Courtney Fletcher and Howard E. Gendelman (UNMC)
Pooja Jain (Drexel University)
Philipa Santangelo (Wallace H. Coulter Department of Biomedical 

Engineering at Georgia Tech, Atlanta)
Ranga Uday Kumar, Molecular Biology & Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (https://www.jncasr.ac.in/faculty/udaykumar)
Mirko Paiardini, Emory University (http://vaccines.emory.edu/faculty-evc/primary-faculty/paiardini_mirko.html)
Mahesh Mohan, Tulane University (https://medicine.tulane.edu/departments/microbiology-immunology-tnprc/faculty/mahesh-mohan-dvm-ms-phd)

Funding

Celularity Inc. “Role of placental stem cell-derived natural killer cells (CYNK) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection”

1R21 Supplemental award (Chand PI) “Effects of SARS-CoV-2 Proteins on Airway Mucous Response and Associated LncRNAs

5P30 CA036727-33 (Cowen PI) The Buffett Cancer Center administrative supplement on “COVID-19 Antigen Team for Immunotherapy and Monitoring Patient Immune Response”

Frances E. Lageschulte and Evelyn B. Weese New Frontiers in Medical Research Fund  

Limiting HIV establishment and maintenance by preserving intestinal immunity
MPI: Byrareddy/Paiardini
Source: NIH/NIAID R01AI129745
In this project, we will explore the therapeutic potential of a combined interleukin (IL)-21 and anti-α4β7 Ab intervention to reduce gut damage and immune activation, improve antiviral responses, and limit the size of the reservoir in ART-treated, SIV-infected rhesus macaques.

Role of HIV Env glycosylation in mucosal transmission
PI: Byrareddy, S.
Source: NIH/NIAID R01 AI113883
This project will aim to investigate and compare glycosylation patterns between linked transmission and founder viruses from recently transmitting couples in /Africa and test in a nonhuman primate model whether glycosylation is a major determinant in the ability of a virus to transmit across the mucosal surface.

Chronic HIV Infection and Aging in NeuroAIDS (CHAIN) Center
MPI: Buch, S. and Fox, H.; Cell-Tissue-Animal Core Leader: Byrareddy, S.
Source: NIH/NIMH P30MH062261
This is a Center grant to provide Administrative and Core Support for scientists investigating NeuroAIDS.

The brain as a SIV reservoir under suppressive cART potentiation by drugs of abuse
MPI: Fox H./Byrareddy S./Buch S.
Source: R01DA043164-01
Using the SIV/macaque system, we will determine whether the brain is a viral reservoir in the setting of effective treatment.

The combinatorial effects of opiates and the emerging promoter-variant strains of HIV-1 subtype C on HIV neuropathogensis and latency
MPI: Buch S/Byrareddy S/Fox H.
Source: R01DA041751-01
In this proposal, we plan to investigate the involvement of the combinatorial effects of opiates and the emerging promoter-variant strains of HIV-1 subtype C on HIV neuropathogenesis and latency and  to test this hypothesis in a primate model.

Host-Directed Therapy to Augment anti-M tuberculosis in Responses in the Setting of HIV Co-infection and to Sterilize the Tuberculoma
PI: Byrareddy S.
Source: Tulane University

Personnel

Arpan Acharaya, PhD Instructor
Samuel D. Johnson Graduate Research Assistant
Kabita Pandey Graduate Research Assistant
Rajesh Rajaiah, PhD Instructor
Vandana Thakur, PhD Post-Doctoral Researcher

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