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Research Goals
Collaborators
Funding
Techniques used in the laboratory
Personnel
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Dr. Byrareddy's biographical information
Lab Phone: 402-559-3028
Research Goals
Long-term goals of my laboratory are to participate in efforts to set up well-controlled clinical cohorts and in tandem with testing the outcome in relevant animal models as a synergistic platform for preclinical development of vaccines by
- developing biologically relevant primate models
- understanding the role of HIV env glycosylation in mucosal transmission
- providing a functional cure for HIV
- using mechanistic studies of neuroAIDS/drug abuse
- studying dynamics of host-virus interaction during acute SIV/HIV infection
Collaborators
Aftab Ansari, Eric Hunter, and Paul Spearman, (Emory University)
Francois Villinger (New Iberia Research Center, University of Louisiana, Lafayette)
Richard Cummings (Harvard University)
James Arthos and Claudia Cicala (NIH)
Michael Barry (Mayo Clinic)
Nebraska Food for Health Center at the University of Nebraska
Shilpa Buch, Howard Fox, Courtney Fletcher and Howard E. Gendelman (UNMC)
Pooja Jain (Drexel University)
Philipa Santangelo (Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech, Atlanta)
Funding
Limiting HIV establishment and maintenance by preserving intestinal immunity
MPI: Byrareddy/PaiardiniNIH/NIAID R01AI129474-01A1
In this project we will explore the therapeutic potential of a combined interleukin (IL)-21 and anti-α4β7 Ab intevention to reduce gut damage and immune activation, improve antiviral responses, and limit the size of the reservoir in ART-treated, SIV-infected rhesus macaques.
Role of HIV Env glycosylation in mucosal transmission
PI: Byrareddy, S.
NIH/NIAID R01 AI113883
This project will aim investigate and compare glycosylation patterns between linked transmission and founder viruses from recently transmitting couples in /Africa and test in a nonhuman primate model whether glycosylation is a major determinant in the ability of a virus to transmit across the mucosal surface.
Transmitted/Founder SHIV macaque model
PI: Byrareddy, S.
NIH/NIAID R21AI114415
This project will develop robust SHIV challenge stocks for non-human primate studies using Transmitted/Founder clade C viruses from African heterosexual cohort.
Chronic HIV Infection and Aging in NeuroAIDS (CHAIN) Center
PI: Fox, H; Cell-Tissue-Animal Core Leader: Byrareddy, S.
NIH/NIMH P30MH062261
This is a Center grant to provide Administrative and Core Support for scientists investigating NeuroAIDS.
The brain as a SIV reservoir under suppressive cART potentiation by drugs of abuse
MPI: Fox H./Byrareddy S./Buch S.
R01DA043164-01
Using the SIV/macaque system, we will determine whether the brain is a viral reservoir in the setting of effective treatment.
The combinatorial effects of opiates and the emerging promoter-variant strains of HIV-1 subtype C on HIV neuropathogensis and latency
MPI: Buch S/Byrareddy S/Fox H.
R01DA041751-01
In this proposal, we plan to investigate the involvement of the combinatorial effects of opiates and the emerging promoter-variant strains of HIV-1 subtype C on HIV neuropathogenesis and latency and to test this hypothesis in a primate model.
Targeting gut-brain axis to eliminate CNS reservoirs
PI: Byrareddy S.
R21 MH113455-01
In this project, we will aim at modifying immune cell targeting to reduce the accumulation of infected cells in the both the gut and CNS using monkey as model.
Molecular mechanisms underlying Zika virus mediated neuropathogenesis
Nebraska Neuroscience Alliance Endowed Fund
MPI: Byrareddy S. and Gorantla, S.
Personnel
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Rajnish Dave |
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Debashis Dutta |
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Samuel D. Johnson |
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| Lindsey Knight Research Technologist I |
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| Lepakshe Madduri Research Technologist |
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| Omalla A. Olwenyi Graduate Research Assistant |
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| Nanda Kishore Routhu Post Doc Research Associate |
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| Srijayaprakash Uppada Post Doc Research Associate |
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Dr. Byrareddy's home page
Dr. Byrareddy's biographical information