Siddappa Byrareddy, Ph.D.

Associate Professor

Durham Research Center 8047
58800 Nebraska Medical Center
Omaha, NE  68198-5880

Phone: 402-559-5416
E-mail: Sid Byrareddy, Ph.D.

Keywords: HIV/SIV/SHIV, neuroAIDS, transmission, drugs of abuse, HIV cure, gut homing molecules

In the News
Research Summary
Long Range Goals
Representative Publications
Dr. Byrareddy's biographical information
Visit Dr. Byrareddy's laboratory

Currently recruiting graduate students. Please contact if you are interested. 

In the News

InterCOM | July/August 2017
Research highlights

UNMC Newsroom | May 30, 2017
Research highlights

iLEAD graduates a new group of faculty leaders
UNMC Today | May 23, 2017

Under the Microscope: Promising HIV research
UNMC Today | December 8, 2016

Sustained virologic control in SIV+ macaques after antiretroviral and a4b7 antibody therapy
Science. 2016 Oct 14;354(6309):197-202  | Abstract Reprint  |  Full text
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Possible HIV breakthrough published in Science
Emory University public relations via UNMC Today | October 14, 2016

New faculty spotlight: Sid Byrareddy, Ph.D.

Research Summary

Byrareddy Research CartoonDespite three decades since the discovery of Human Immunodeficiency Virus (HIV) as the etiologic pathogen of the origin of Acquired Immune Deficiency Syndrome (AIDS), the prospect of a protective vaccine against the virus remains a formidable challenge. Currently, ~35.5 million people are infected with HIV-1 worldwide [] and more than 50,000 new infections occur every year. Therefore, an effective AIDS vaccine remains an urgent need to prevent and control the spread of HIV. The research in my laboratory is focused on the development of an effective AIDS vaccine in a nonhuman primate model of human HIV infection using molecular biology, virology, immunology, systems biology, proteomic and genomic tools to understand host-virus dynamics and prevention strategies of HIV/AIDS and other infectious diseases in general.

My future and current research interests area outlined in the accompanying cartoon.

Long-range Goals of the Laboratory:

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Representative publications (out of more than 50 total)

  1. Byrareddy SN, Sidell N, Zhao C, Dunbar P, Little D, Yang GX, Pierzchalski K, Kane MA, Mayne AE, Arthos J, Cicala C, Song B, Soares MA, Villinger F, Fauci AS, Ansari AA. Species-Specific Differences in the Expression and Regulation of Alpha 4 Beta7 (α4β7) integrin in Various Non Human Primates. J Immunol. 2015 Jun 15;194(12):5968-79
  2. Santangelo PJ, Rogers KA, Zurla C, Gumber S, Strait K, Conner-Stroud F, Schister DM, Amancha PK, Hong JJ, Byrareddy SN, Hoxie JA, Vidakovic B, Ansari AA, Hunter E, Villinger F. Whole body ImmunoPET reveals active viral reservoirs in SIV infected ART-treated aviremic macaques and elite controllers. Nat Methods. 2015 Mar 9. doi: 10.1038/nmeth.3320 

  3. Byrareddy SN, Kallam B, Arthos J, Cicala C, Kersh E, McNicholl JM, Hanson D, Reimann K, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo P, Villinger F, Fauci AS, Ansari AA. Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection. Nat Med. 2014 Dec;20(12):1397-400
  4. Kramer VG, Byrareddy SN. The Value of HIV Protective Epitope Research for Informed Vaccine Design Against Diverse Viral Pathogens. Expert Rev Vaccines. 2014 Aug;13(8):935-7
  5. Courtney CL, Ethun KF, Villinger F, Ruprecht RM, Byrareddy SN. Massive Occlusive Thrombosis of the Pulmonary Artery in Pigtailed Macaques Chronically Infected with R5-Tropic Simian-human Immunodeficiency Virus. J Med Primatol. 2015 Feb; 44(1):35-9

More publications in PubMed

Dr. Byrareddy's biographical information
Visit Dr. Byrareddy's laboratory
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