Siddappa Byrareddy, PhD

Associate Professor, Vice-Chair of ResearchSid Byrareddy

Durham Research Center 8052
58800 Nebraska Medical Center
Omaha, NE  68198-5880

Phone: 402-559-5416
E-mail: Sid Byrareddy, Ph.D.

Keywords: HIV/SIV/SHIV, neuroAIDS, transmission, drugs of abuse, HIV cure, gut homing molecules, immunotherapy, mucositis, Zika virus, SARS-CoV-2, COVID-19 


In the news
Research summary
Ongoing and future research projects
Representative publications
Dr. Byrareddy's biographical information
Visit Dr. Byrareddy's laboratory

Currently recruiting graduate students. Please contact if you are interested. 

Research Technologist position available. Visit Opportunities page.


In the news

Forbes | July 6, 2020
Cannabis may reduce deadly COVID-19 lung inflammation, researchers explain why

Business Insider | May 10, 2020
As the coronavirus case curve flattens, daily deaths may stay high, experts warn

UNMC for the Record | July 20, 2018
Student in Dr. Byrareddy's lab earns major national scholarship

UNMC Today | January 30, 2018
Distinguished Scientist: Siddappa Byrareddy, PhD

InterCOM | July/August 2017
Research highlights

UNMC Newsroom | May 30, 2017
Research highlights

UNMC Today | May 23, 2017
iLEAD graduates a new group of faculty leaders

UNMC Today | December 8, 2016
Under the Microscope: Promising HIV research

View comments from other journals, universities and news organizations.


Research summary

Our laboratory focuses on understanding host-virus dynamics using molecular biology, virology, immunology, systems biology, and genomic tools to develop prevention strategies for HIV/AIDS and other infectious diseases such as Zika virus. We use non-human primate models for most of the in vivo studies. Our long-term goal is to set up well-controlled clinical cohorts in tandem for testing the disease outcomes in relevant animal models as a synergistic platform for preclinical development of vaccines/therapeutics.

Ongoing and future research interests

  1. Dynamics of host-virus interaction and development of biologically relevant primate models. Our research is focused on the generation of biologically relevant primate models using Transmitter/Founder viruses (T/F) env.  We mostly focus on developing a non-human primate model to study HIV associated neurocognitive disorders (HAND) in relevant animal model in the era of cART. Furthermore, predominant route of HIV-1 infection occurs following sexual contact with vaginal transmission accounting for the majority of all newly acquired infections worldwide. Knowledge on how HIV disseminates within the genital mucosa following initial introduction and subsequent gradual spread to the lymphoid compartments as well as CNS is still elusive. We will address these questions systematically using biologically relevant primate models.
  2. To understand the role of Env Glycosylation in mucosal transmission/host virus interaction. Viral env glycosylation is thought to influence preferential transmission by selecting receptors for cellular entry and rendering its susceptibility to neutralizing antibodies. Our laboratory evaluates the role of env glycans using a set of HIV-1 clade C molecular clones predominantly obtained from transmitted/founder (T/F) viruses of a Zambian cohort. The overall goal of this research is to provide improved understanding of virus-host relationships that promote transmission and contribute to the rate of disease progression following infection, which are in turn critical for effective HIV vaccine design.
  3. Functional Cure of HIV. We are developing strategies aimed at limiting inflammation and improving immune responses in the gut as well as other lymphoid tissues. Our ultimate goal is to develop combinatorial therapeutic intervention strategies for antiretroviral therapy treatment.
  4. Mechanistic studies of NeuroAIDS/Drugs of abuse. We are using the SIV/macaque models to evaluate the brain as a viral reservoir in the setting of antiretroviral treatment. Although most reservoir work has concentrated mostly on CD4+ T cells, these are not the primary infected cells in the CNS, where long-lived macrophages and microglia take this role instead. Furthermore, drugs of abuse are frequently co-morbid with HIV-1 infection and further affects the CNS. We are studying the effects of drugs of abuse/immunotherapy on modulating the effectiveness of antiretroviral treatment by monitoring changes in cellular/immunological markers possibly impacting infection and tissue migration both in brain cells as well as in lymphoid cells.
  5. Zika Virus host-virus interactions. The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. Our laboratory began working on this virus in late 2016 and developed several leads in order to understand the virus pathogenesis and development of therapeutics. We have demonstrated that intersecting polyamine catabolism pathways with polyamine analogues derivatives can inhibit ZIKV replication. As a result, we are currently investigating polyamine analogues as potential treatment to Zika. We also developed a macaque model for Zika infection in order to understand virus immune cell dynamics, glycosylation, and co-infection with other viruses, such as HIV, dengue virus.

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Representative publications

  1. Pino M, Uppada SB, Pandey K, King C, Nguyen K, Shim I, Rogers K, Villinger F, Paiardini M, Byrareddy SN. Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques. Front Immunol. 2020 Jul 17;11:1275. doi: 10.3389/fimmu.2020.01275. PMID: 32765488; PMCID: PMC7379916.

  2. Alvarez X, Sestak K, Byrareddy SN, Mohan M. Long Term Delta-9-tetrahydrocannabinol Administration Inhibits Proinflammatory Responses in Minor Salivary Glands of Chronically Simian Immunodeficieny Virus Infected Rhesus Macaques. Viruses. 2020 Jul 1;12(7):E713. doi: 10.3390/v12070713. PMID: 32630206.

  3. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020 May;109:102433. doi: 10.1016/j.jaut.2020.102433. Epub 2020 Feb 26. PMID: 32113704; PMCID: PMC7127067.

  4. Dave RS, Ali H, Sil S, Knight LA, Pandey K, Madduri LSV, Qiu F, Ranga U, Buch S, Byrareddy SN. NF-κB Duplications in the Promoter-Variant HIV-1C LTR Impact Inflammation Without Altering Viral Replication in the Context of Simian Human Immunodeficiency Viruses and Opioid-Exposure. Front Immunol. 2020 Jan 31;11:95. doi: 10.3389/fimmu.2020.00095. PMID: 32076422; PMCID: PMC7006833.

  5. Frank I, Acharya A, Routhu NK, Aravantinou M, Harper JL, Maldonado S, Sole Cigoli M, Semova S, Mazel S, Paiardini M, Derby N, Byrareddy SN, Martinelli E. A Tat/Rev Induced Limiting Dilution Assay to Measure Viral Reservoirs in Non-Human Primate Models of HIV Infection. Sci Rep. 2019 Aug 19;9(1):12078. doi: 10.1038/s41598-019-48354-3. PMID: 31427605; PMCID: PMC6700126.

  6. Kumar V, Torben W, Mansfield J, Alvarez X, Vande Stouwe C, Li J, Byrareddy SN, Didier PJ, Pahar B, Molina PE, Mohan M. Cannabinoid Attenuation of Intestinal Inflammation in Chronic SIV-Infected Rhesus Macaques Involves T Cell Modulation and Differential Expression of Micro-RNAs and Pro-inflammatory Genes. Front Immunol. 2019 Apr 30;10:914. doi: 10.3389/fimmu.2019.00914. PMID: 31114576; PMCID: PMC6503054.

  7. Zenere G, Olwenyi OA, Byrareddy SN, Braun SE. Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review. Drug Discov Today. 2019 Apr;24(4):983-991. doi: 10.1016/j.drudis.2019.02.002. Epub 2019 Feb 13. PMID: 30771481; PMCID: PMC7065919.

  8. Namasivayam V, Vanangamudi M, Kramer VG, Kurup S, Zhan P, Liu X, Kongsted J, Byrareddy SN. The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic. J Med Chem. 2019 May 23;62(10):4851-4883. doi: 10.1021/acs.jmedchem.8b00843. Epub 2018 Dec 27. PMID: 30516990; PMCID: PMC7049092.

  9. Santangelo PJ, Cicala C, Byrareddy SN, Ortiz KT, Little D, Lindsay KE, Gumber S, Hong JJ, Jelicic K, Rogers KA, Zurla C, Villinger F, Ansari AA, Fauci AS, Arthos J. Early treatment of SIV+ macaques with an α4β7mAb alters virus distribution and preserves CD4+ T cells in later stages of infection. Mucosal Immunol. 2018 May;11(3):932-946. doi: 10.1038/mi.2017.112. Epub 2017 Dec 20. PMID: 29346349; PMCID: PMC5976508.

  10. Santangelo PJ, Rogers KA, Zurla C, Blanchard EL, Gumber S, Strait K, Connor-Stroud F, Schuster DM, Amancha PK, Hong JJ, Byrareddy SN, Hoxie JA, Vidakovic B, Ansari AA, Hunter E, Villinger F. Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques. Nat Methods. 2015 May;12(5):427-32. doi: 10.1038/nmeth.3320. Epub 2015 Mar 9. PMID: 25751144; PMCID: PMC4425449.

  11. Byrareddy SN, Kallam B, Arthos J, Cicala C, Nawaz F, Hiatt J, Kersh EN, McNicholl JM, Hanson D, Reimann KA, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo PJ, Villinger F, Fauci AS, Ansari AA. Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection. Nat Med. 2014 Dec;20(12):1397-400. doi: 10.1038/nm.3715. Epub 2014 Nov 24. PMID: 25419708; PMCID: PMC4257865.

  12. Takahashi Y, Byrareddy SN, Albrecht C, Brameier M, Walter L, Mayne AE, Dunbar P, Russo R, Little DM, Villinger T, Khowawisetsut L, Pattanapanyasat K, Villinger F, Ansari AA. In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infection. PLoS Pathog. 2014 Mar 6;10(3):e1003929. doi: 10.1371/journal.ppat.1003929. PMID: 24603870; PMCID: PMC3946395.

  13. Dutta D, Johnson S, Dalal A, Deymier MJ, Hunter E, Byrareddy SN. High throughput generation and characterization of replication-competent clade C transmitter-founder simian human immunodeficiency viruses. PLoS One. 2018 May 14;13(5):e0196942. doi: 10.1371/journal.pone.0196942. PMID: 29758076; PMCID: PMC5951672.

More publications in PubMed


Dr. Byrareddy's biographical information
Visit Dr. Byrareddy's laboratory
Dr. Byrareddy’s COVID-19 research
 
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