Durham Research Center 8047
58800 Nebraska Medical Center
Omaha, NE 68198-5880
E-mail: Sid Byrareddy, Ph.D.
Keywords: HIV/SIV/SHIV, neuroAIDS, transmission, drugs of abuse, HIV cure, gut homing molecules
Currently recruiting graduate students. Please contact if you are interested.
InterCOM | July/August 2017
UNMC Newsroom | May 30, 2017
iLEAD graduates a new group of faculty leaders
UNMC Today | May 23, 2017
Under the Microscope: Promising HIV research
UNMC Today | December 8, 2016
Sustained virologic control in SIV+ macaques after antiretroviral and a4b7 antibody therapy
Science. 2016 Oct 14;354(6309):197-202 | Abstract | Reprint | Full text
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Possible HIV breakthrough published in Science
Emory University public relations via UNMC Today | October 14, 2016
Despite three decades since the discovery of Human Immunodeficiency Virus (HIV) as the etiologic pathogen of the origin of Acquired Immune Deficiency Syndrome (AIDS), the prospect of a protective vaccine against the virus remains a formidable challenge. Currently, ~35.5 million people are infected with HIV-1 worldwide [www.UNAIDS.org] and more than 50,000 new infections occur every year. Therefore, an effective AIDS vaccine remains an urgent need to prevent and control the spread of HIV. The research in my laboratory is focused on the development of an effective AIDS vaccine in a nonhuman primate model of human HIV infection using molecular biology, virology, immunology, systems biology, proteomic and genomic tools to understand host-virus dynamics and prevention strategies of HIV/AIDS and other infectious diseases in general.
My future and current research interests area outlined in the accompanying cartoon.
- Long-term goals of my laboratory are to participate in efforts to set up well-controlled clinical cohorts and in tandem with testing the outcome in relevant animal models as a synergistic platform for preclinical development of vaccines.
- Byrareddy SN, Sidell N, Zhao C, Dunbar P, Little D, Yang GX, Pierzchalski K, Kane MA, Mayne AE, Arthos J, Cicala C, Song B, Soares MA, Villinger F, Fauci AS, Ansari AA. Species-Specific Differences in the Expression and Regulation of Alpha 4 Beta7 (α4β7) integrin in Various Non Human Primates. J Immunol. 2015 Jun 15;194(12):5968-79
- Santangelo PJ, Rogers KA, Zurla C, Gumber S, Strait K, Conner-Stroud F, Schister DM, Amancha PK, Hong JJ, Byrareddy SN, Hoxie JA, Vidakovic B, Ansari AA, Hunter E, Villinger F. Whole body ImmunoPET reveals active viral reservoirs in SIV infected ART-treated aviremic macaques and elite controllers. Nat Methods. 2015 Mar 9. doi: 10.1038/nmeth.3320
- Byrareddy SN, Kallam B, Arthos J, Cicala C, Kersh E, McNicholl JM, Hanson D, Reimann K, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo P, Villinger F, Fauci AS, Ansari AA. Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection. Nat Med. 2014 Dec;20(12):1397-400
- Kramer VG, Byrareddy SN. The Value of HIV Protective Epitope Research for Informed Vaccine Design Against Diverse Viral Pathogens. Expert Rev Vaccines. 2014 Aug;13(8):935-7
- Courtney CL, Ethun KF, Villinger F, Ruprecht RM, Byrareddy SN. Massive Occlusive Thrombosis of the Pulmonary Artery in Pigtailed Macaques Chronically Infected with R5-Tropic Simian-human Immunodeficiency Virus. J Med Primatol. 2015 Feb; 44(1):35-9