Dr. Ciborowski's laboratory

Research Goals
Collaborators
Funding
Techniques used in the lab
Personnel
Dr. Ciborowski's home page
Dr. Ciborowski's biographical information
Lab phone:  402-559-2054


Research Goals

Research in the Proteomics Laboratory is focused on the correlation of structure and function of proteins, their receptors and the impact of post translational modifications on their functions. Unlike genes, which all use the same code, each protein has unique physical properties, preventing attempts to develop a single method to study their structure and function in living organisms.


Collaborators

Yutong Liu, Ph.D., Department of Radiology, UNMC
Howard E. Gendelman, M.D., Department of Pharmacology and Experimental Neuroscience, UNMC
Howard S. Fox, M.D., Ph.D., Department of Pharmacology and Experimental Neuroscience, UNMC
R. Lee Mosley, Ph.D., Department of Pharmacology and Experimental Neuroscience, UNMC
Huangui Xiong, M.D., Ph.D.,  Department of Pharmacology and Experimental Neuroscience, UNMC
Georgette Kanmogne, Ph.D., M.P.H.,  Department of Pharmacology and Experimental Neuroscience, UNMC
Keshore Bidasee, Ph.D., Department Pharmacology and Experimental Neuroscience, UNMC
Mike Belshan, Ph.D., Creighton University, Omaha, NE
Igor Grant, M.D., University of California, San Diego
Ronald Ellis, M.D., Ph.D., University of California, San Diego
Scott Letendre, M.D., University of California, San Diego
Loyda Melendez, Ph.D., University of Puerto Rico Medical Science Campus.
Juliana Perez-Laspiur,  Ph.D., University of Puerto Rico Medical Science Campus


Funding

Macrophage; Meth; HIV and Histones
PI: Ciborowski, P
Source: NIH DA043258
The transformation of HIV to a chronic disease represents a great success of therapy but brings new clinical problems due to long-term infection and effects of coexisting factors such as drug abuse that affects many systems including the brain and cardiovascular systems. Macrophages, key components of the immune system, play many roles in the persistence of infection as well as disease causation. We propose to use a global approach to investigate the effects of HIV infection and drug abuse on macrophage’s epigenetic regulatory mechanisms that should lead us to better understand molecular mechanisms of disease and propose new targets for therapy.

Chronic HIV Infection and Aging in NeuroAIDS (CHAIN) Center (MPI: Buch, S/Fox, H)
Role: Proteomics Core Leader
NIH/NIMH 5P30 MH062261
This is a Center grant to provide Administrative and Core Support for scientists investigating NeuroAIDS.


Techniques used in the lab


Personnel

Emma Harwood
Data Coordinator I


Emma Harwood

Katarzyna Macur, Ph.D.
Visiting Associate Professor


 

Andrew Schissel
Research Technologist 1

 Andrew Schissel

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