Guoku Hu, PhD

Associate ProfessorGuoku Hu

Durham Research Center 8044
985880 University of Nebraska Medical Center
Omaha, NE 68198-5880
email Guoku Hu


HIV, drugs of abuse, exosomes, non-coding RNAs

Professional Summary
Research Interests
Representative Publications
Dr. Hu's biographical information
Visit Dr. Hu's laboratory

Currently recruiting graduate students. Please contact if you are interested. 

Professional Summary

My long term goal is to elucidate the functional aspects of exosomes and noncoding RNAs in NeuroAIDS and other neurodegenerative diseases and to identify novel therapeutic strategies that may enhance neuronal function and survival in these disorders.

Research Interests

HIV and drug abuse synergy, exosomes, noncoding RNAs

Representative Publications

Liao K, Niu F, Dagur RS, He M, Tian C, Hu G*. Intranasal Delivery of lincRNA-Cox2 siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in Mice. J Neuroimmune Pharmacol. 2019 Jul 20. doi: 10.1007/s11481-019-09864-z. PubMed PMID: 31325121.

Cao M, Li H, Zhao J*, Cui J*Hu G*. Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease. Neurobiol Aging. 2019 Jun 6;81:116-126. doi: 10.1016/j.neurobiolaging. 2019.05.023. [Epub ahead of print] PubMed PMID: 31280115.

Niu F, Liao K, Hu G, Sil S, Callen S, Guo ML, Yang L, Buch S. Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS. J Cell Biol. 2019 Feb 4;218(2):700-721. doi: 10.1083/jcb.201712011. Epub 2019 Jan 9. PubMed PMID: 30626719; PubMed Central PMCID: PMC6363463.

Cao M, Zhao J*Hu G*. Genome-wide methods for investigating long noncoding RNAs. Biomed Pharmacother. 2019 Mar;111:395-401. doi: 10.1016/j.biopha.2018.12.078. Epub 2018 Dec 27. Review. PubMed PMID: 30594777; PubMed Central PMCID: PMC6401243.

Hu G*, Liao K, Niu F, Yang L, Dallon BW, Callen S, Tian C, Shu J, Cui J, Sun Z, Lyubchenko YL, Ka M, Chen XM, Buch S*. Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration. Mol Ther Nucleic Acids. 2018 Dec 7;13:450-463. doi: 10.1016/j.omtn.2018.09.019. Epub 2018 Sep 29. PubMed PMID: 30388619; PubMed Central PMCID: PMC6202788.

Periyasamy P, Thangaraj A, Guo ML, Hu G, Callen S, Buch S. Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis. J Neurosci. 2018 Jun 6;38(23):5367-5383. doi:10.1523/JNEUROSCI.3474-17.2018. Epub 2018 May 14. PubMed PMID: 29760177; PubMed Central PMCID: PMC5990983.

Hu G*, Niu F, Humburg BA, Liao K, Bendi S, Callen S, Fox HS, Buch S*. Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis. Oncotarget. 2018 Jan 1;9(26):18648-18663. doi: 10.18632/oncotarget.24307. eCollection 2018 Apr 6. Review. PubMed PMID: 29719633; PubMed Central PMCID: PMC5915100.

Ma S, Ming Z, Gong AY, Wang Y, Chen X, Hu G, Zhou R, Shibata A, Swanson PC, Chen XM. A long noncoding RNA, lincRNA-Tnfaip3, acts as a coregulator of NF-κB to modulate inflammatory gene transcription in mouse macrophages. FASEB J. 2017 Mar;31(3):1215-1225. doi: 10.1096/fj.201601056R. Epub 2016 Dec 15. PubMed PMID: 27979905; PubMed Central PMCID: PMC6191062.

Hu G, Yang L, Cai Y, Niu F, Mezzacappa F, Callen S, Fox HS, Buch S. Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications. Cell Death Dis. 2016 Nov 24;7(11):e2481. doi: 10.1038/cddis.2016.336. Review. PubMed PMID: 27882942; PubMed Central PMCID: PMC5260908.

Cai Y, Yang L, Hu G, Chen X, Niu F, Yuan L, Liu H, Xiong H, Arikkath J, Buch S. Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy. J Cell Biol. 2016 Oct 24;215(2):245-258. Epub 2016 Oct  17. PubMed PMID: 27810915; PubMed Central PMCID: PMC5084649.

Hu G, Gong AY, Wang Y, Ma S, Chen X, Chen J, Su CJ, Shibata A, Strauss-Soukup JK, Drescher KM, Chen XM. LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling. J Immunol. 2016 Mar 15;196(6):2799-2808. doi:10.4049/jimmunol.1502146. Epub 2016 Feb 15. PubMed PMID: 26880762; PubMed Central PMCID: PMC4779692.

Xie H, Lei N, Gong AY, Chen XM, Hu G*. Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i. Hum Immunol. 2014 Aug;75(8):760-5. doi: 10.1016/j.humimm.2014.05.007. Epub 2014 May 24. PubMed PMID: 24862934; PubMed Central PMCID: PMC4327856.

Hu G, Gong AY, Roth AL, Huang BQ, Ward HD, Zhu G, Larusso NF, Hanson ND, Chen XM. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. PLoS Pathog. 2013;9(4):e1003261. doi: 10.1371/journal.ppat.1003261. Epub 2013 Apr 4. PubMed PMID: 23592986; PubMed Central PMCID: PMC3617097.

Hu G, Drescher KM, Chen XM. Exosomal miRNAs: Biological Properties and Therapeutic Potential. Front Genet. 2012 Apr 20;3:56. doi: 10.3389/fgene.2012.00056. eCollection 2012. PubMed PMID: 22529849; PubMed Central PMCID: PMC3330238.

Hu G, Zhou R, Liu J, Gong AY, Chen XM. MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection. J Infect Dis. 2010 Jul 1;202(1):125-35. doi: 10.1086/653212. PubMed PMID: 20486857; PubMed Central PMCID: PMC2880649. 

Additional publications in PubMed

Dr. Hu's biographical information
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