Guoku Hu, PhD

Associate ProfessorGuoku Hu

Durham Research Center 8044
985880 University of Nebraska Medical Center
Omaha, NE 68198-5880
email Guoku Hu


HIV, drugs of abuse, exosomes, non-coding RNAs

Professional Summary
Research Interests
Representative Publications
Dr. Hu's biographical information
Visit Dr. Hu's laboratory

Currently recruiting graduate students. Please contact if you are interested. 

Professional Summary

My long term goal is to elucidate the functional aspects of exosomes and noncoding RNAs in NeuroAIDS and other neurodegenerative diseases and to identify novel therapeutic strategies that may enhance neuronal function and survival in these disorders.

Research Interests

HIV and drug abuse synergy, exosomes, noncoding RNAs

Representative Publications


Ma R, Kutchy NA, Hu G*.  Astrocyte-Derived Extracellular Vesicle-Mediated Activation of Primary Ciliary Signaling Contributes to the Development of Morphine Tolerance. Biol Psychiatry. 2021 Jun 17:S0006-3223(21)01395-0. doi: 10.1016/j.biopsych.2021.06.009. Online ahead of print. PMID: 34417054.

Chivero ET*, Dagur RS, Peeples ES, Sil S, Liao K, Ma R, Chen L, Gurumurthy CB, Buch S, Hu G*. Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders. Cell Mol Life Sci. 2021 Jun;78(11):4849-4865. doi: 10.1007/s00018-021-03824-8. Epub 2021 Apr 5. PMID: 33821293.

Liao K, Niu F, Hu G, Yang L, Dallon B, Villarreal D, Buch S. Morphine-mediated release of miR-138 in astrocyte-derived extracellular vesicles promotes microglial activation. J Extracell Vesicles. 2020 Oct;10(1):e12027. doi: 10.1002/jev2.12027. Epub 2020 Nov 19. PMID: 33304479.

Chivero ET, Liao K, Niu F, Tripathi A, Tian C, Buch S*, Hu G*. Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia. Front Cell Dev Biol. 2020 Jul 30;8:573. doi: 10.3389/fcell.2020.00573. eCollection 2020. PMID: 32850781.

Sil S, Hu G, Liao K, Niu F, Callen S, Periyasamy P, Fox HS, Buch S. HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis. PLoS Biol. 2020 May 26;18(5):e3000660. doi: 10.1371/journal.pbio.3000660. eCollection 2020 May. PMID: 32453744.

Dagur RS, Liao K, Sil S, Niu F, Sun Z, Lyubchenko YL, Peeples ES, Hu G*, Buch S*. Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats. J Extracell Vesicles. 2019 Dec 20;9(1):1703249. doi: 10.1080/20013078.2019.1703249. eCollection 2020. PMID: 32002168.

Liao K, Niu F, Dagur RS, He M, Tian C, Hu G*. Intranasal Delivery of lincRNA-Cox2 siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in Mice. J Neuroimmune Pharmacol. 2019 Jul 20. doi: 10.1007/s11481-019-09864-z. PMID: 31325121.

Cao M, Li H, Zhao J*, Cui J*Hu G*. Identification of age- and gender-associated long noncoding RNAs in the human brain with Alzheimer's disease. Neurobiol Aging. 2019 Jun 6;81:116-126. doi: 10.1016/j.neurobiolaging. 2019.05.023. [Epub ahead of print] PMID: 31280115.

Niu F, Liao K, Hu G, Sil S, Callen S, Guo ML, Yang L, Buch S. Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS. J Cell Biol. 2019 Feb 4;218(2):700-721. doi: 10.1083/jcb.201712011. Epub 2019 Jan 9. PMID: 30626719; PubMed Central PMCID: PMC6363463.

Cao M, Zhao J*Hu G*. Genome-wide methods for investigating long noncoding RNAs. Biomed Pharmacother. 2019 Mar;111:395-401. doi: 10.1016/j.biopha.2018.12.078. Epub 2018 Dec 27. Review. PMID: 30594777; PubMed Central PMCID: PMC6401243.

Hu G*, Liao K, Niu F, Yang L, Dallon BW, Callen S, Tian C, Shu J, Cui J, Sun Z, Lyubchenko YL, Ka M, Chen XM, Buch S*. Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration. Mol Ther Nucleic Acids. 2018 Dec 7;13:450-463. doi: 10.1016/j.omtn.2018.09.019. Epub 2018 Sep 29. PMID: 30388619; PubMed Central PMCID: PMC6202788.

Hu G*, Niu F, Humburg BA, Liao K, Bendi S, Callen S, Fox HS, Buch S*. Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis. Oncotarget. 2018 Jan 1;9(26):18648-18663. doi: 10.18632/oncotarget.24307. eCollection 2018 Apr 6. Review. PMID: 29719633; PubMed Central PMCID: PMC5915100.

Hu G, Gong AY, Wang Y, Ma S, Chen X, Chen J, Su CJ, Shibata A, Strauss-Soukup JK, Drescher KM, Chen XM. LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling. J Immunol. 2016 Mar 15;196(6):2799-2808. doi:10.4049/jimmunol.1502146. Epub 2016 Feb 15. PMID: 26880762; PubMed Central PMCID: PMC4779692.

Hu G, Gong AY, Roth AL, Huang BQ, Ward HD, Zhu G, Larusso NF, Hanson ND, Chen XM. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. PLoS Pathog. 2013;9(4):e1003261. doi: 10.1371/journal.ppat.1003261. Epub 2013 Apr 4. PMID: 23592986; PubMed Central PMCID: PMC3617097.

Hu G, Drescher KM, Chen XM. Exosomal miRNAs: Biological Properties and Therapeutic Potential. Front Genet. 2012 Apr 20;3:56. doi: 10.3389/fgene.2012.00056. eCollection 2012. PMID: 22529849; PubMed Central PMCID: PMC3330238.

Additional publications in PubMed

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