Guoku Hu, Ph.D.

Assistant ProfessorGuoku Hu

Durham Research Center 8046
985880 University of Nebraska Medical Center
Omaha, NE 68198-5880

402-559-3167
Guoku Hu

Keywords: 

HIV, drugs of abuse, exosomes, non-coding RNAs


Professional Summary
Research Interests
Representative Publications
Dr. Hu's biographical information


Professional Summary

My long term goal is to elucidate the functional aspects of exosomes and noncoding RNAs in NeuroAIDS and other neurodegenerative diseases and to identify novel therapeutic strategies that may enhance neuronal function and survival in these disorders.


Research Interests

HIV and drug abuse synergy, exosomes, noncoding RNAs


Representative Publications

  1. Hu G, Liao K, Yang L, Pendyala G, Kook Y, Fox HS, Buch S. Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND. J Neuroimmune Pharmacol. 2017. PMID: 28236278. PMC Journal – in Process."
  2. Hu G, Yang L, Cai Y, Niu F, Mezzacappa F, Callen S, Fox HS, Buch S. Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications. Cell Death Dis. 2016 Nov 24;7(11):e2481. PMID: 27882942.  PubMed Central PMCID: PMC5260908.
  3. Cai Y, Yang L, Hu G, Chen X, Niu F, Yuan L, Liu H, Xiong H, Arikkath J, Buch S. Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy. J Cell Biol. 2016 Oct 24;215(2):245-258. PMID: 27810915. PMCID:PMC5084649.
  4. Yang L, Chen X, Simet SM, Hu G, Cai Y, Niu F, Kook Y, Buch SJ. Reactive Oxygen Species/Hypoxia-Inducible Factor-1α/Platelet-Derived Growth Factor-BB Autocrine Loop Contributes to Cocaine-Mediated Alveolar Epithelial Barrier Damage. Am J Respir Cell Mol Biol. 2016. PMID: 27391108. PubMed Central: PMCID: PMC5105185.
  5. Yang L, Chen X, Hu G, Cai Y, Liao K, Buch S. Mechanisms of Platelet-Derived Growth Factor-BB in Restoring HIV Tat-Cocaine-Mediated Impairment of Neuronal Differentiation. Mol Neurobiol. 2016 Nov;53(9):6377-6387. PMID: 26572642. PMCID: PMC4870169.
  6. Yao H, Ma R, Yang L, Hu G, Chen X, Duan M, Kook Y, Niu F, Liao K, Fu M, Hu G, Kolattukudy P, Buch S. t Commun. 2014 Jul 14;5:4386. PMID: 25019481. PubMed Central PMCID: PMC4104446 
  7. Xie H, Lei N, Gong AY, Chen XM, and Hu G*. Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i. Human Immunology 2014, 75: 760-765. PubMed PMID: 24862934; PubMed Central PMCID: PMC4327856.
  8. Hu G, Gong AY, Roth A.L., Huang B.Q., et al. Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense. PLoS Pathog. 2013, 9(4): e1003261. PubMed PMID: 23592986; PubMed Central PMCID: PMC3617097.
  9. Hu G, Yao H, Chaudhuri AD, Duan M, Yelamanchili SV, et al. Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction. Cell Death Dis. 2012 Aug 30;3:e381. PubMed PMID: 22932723; PubMed Central PMCID: PMC3434655.
  10. Yao H, Ma R, Yang L, Hu G, Chen X, Duan M, Kook Y, Niu F, Liao K Fu M, Hu G, Kolattukudy P, and Buch S. MiR-9 promotes microglial activation by targeting MCPIP1. Nature Communications. 2014 Doi: 10.1038/ncomms5386.  PMID 25019481
  11. Hu G, Gong AY, Roth AL, Huang BQ, Ward HD, Zhu G, LaRusso NF, Hanson ND, and Chen XM.  Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense. PLoS Pathog. 2013, 9(4): e1003261. doi:10.1371/journal.ppat.1003261.  PMID 23592986
  12. Duan M, Yao H, Hu G, Chen XM, Lund AK, and Buch S. HIV Tat Induces Expression of ICAM-1 in HUVECs: Implications for miR-221/-222 in HIV-Associated Cardiomyopathy. PLoS ONE. 2013, 8(3): e60170. doi:10.1371/journal.pone.0060170.  PMID 23555914
  13. Bethel-Brown C, Yao H, Hu G, and Buch S. Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation. J Neuroinflammation. 2012, Dec 1; 9(1):262.  PMID 23198981
  14. Hu G, Yao H, Chaudhuri AD, Duan M, Yelamanchili SV, Wen H, Cheney PD, Fox HS and Buch S. Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunction. Cell Death Dis. 2012, August; 3(8): e381.  PMID 22932723
  15. Hu G, Drescher KM and Chen XM. Exosomal miRNAs: Biological Properties and Therapeutic Potential. Front Genet. 2012; 3: 56.  PMID 22529849
  16. Gong AY, Hu G, Zhou R, Liu J, and Chen XM. miR-221 controls expression of intercellular adhesion molecular-1 in epithelial cells in response to Cryptosporidium parvum infection. Int J Parasitol.2011, 397-403.  PMID 21236259 
  17. Yao H, Duan M, Hu G and Buch S. Platelet-derived growth factor B chain is a novel target gene of cocaine-mediated Notch1 signaling: implications for HIV-associated neurological disorders. J Neurosci. 2011, 31(35):12449-54.  PMID 21880906
  18. Hu G, Zhou R, Liu J, Gong AY and Chen XM. MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling-4 in biliary epithelial cells in response to Cryptosporidium parvuminfection. J Infect Dis. 2010, 202(1): 125-35.  PMID 20486857
  19. Hu G, Gong AY, Liu J, Zhou R, Deng and Chen XM. miR-221 suppresses ICAM-1 translation and regulates interferon-gamma-induced ICAM-1 expression in human cholangiocytes.  Am J Physiol Gastro Liver.2010, 298(4):G542-50.  PMID 20110463

Additional publications in PubMed


Dr. Hu's biographical information
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