Guoku Hu, Ph.D.

Assistant ProfessorGuoku Hu

Durham Research Center 8046
985880 University of Nebraska Medical Center
Omaha, NE 68198-5880

Guoku Hu


HIV, drugs of abuse, exosomes, non-coding RNAs

Professional Summary
Research Interests
Representative Publications
Dr. Hu's biographical information

Professional Summary

My long term goal is to elucidate the functional aspects of exosomes and noncoding RNAs in NeuroAIDS and other neurodegenerative diseases and to identify novel therapeutic strategies that may enhance neuronal function and survival in these disorders.

Research Interests

HIV and drug abuse synergy, exosomes, noncoding RNAs

Representative Publications

  1. Yao H, Ma R, Yang L, Hu G, Chen X, Duan M, Kook Y, Niu F, Liao K Fu M, Hu G, Kolattukudy P, and Buch S. MiR-9 promotes microglial activation by targeting MCPIP1. Nature Communications. Doi: 10.1038/ncomms5386.  PMID 25019481
  2. Hu G, Gong AY, Roth AL, Huang BQ, Ward HD, Zhu G, LaRusso NF, Hanson ND, and Chen XM.  Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense. PLoS Pathog. 2013, 9(4): e1003261. doi:10.1371/journal.ppat.1003261.  PMID 23592986
  3. Duan M, Yao H, Hu G, Chen XM, Lund AK, and Buch S. HIV Tat Induces Expression of ICAM-1 in HUVECs: Implications for miR-221/-222 in HIV-Associated Cardiomyopathy. PLoS ONE. 2013, 8(3): e60170. doi:10.1371/journal.pone.0060170.  PMID 23555914
  4. Bethel-Brown C, Yao H, Hu G, and Buch S. Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation. J Neuroinflammation. 2012, Dec 1; 9(1):262.  PMID 23198981
  5. Hu G, Yao H, Chaudhuri AD, Duan M, Yelamanchili SV, Wen H, Cheney PD, Fox HS and Buch S. Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunction. Cell Death Dis.2012, August; 3(8): e381.  PMID 22932723
  6. Hu G, Drescher KM and Chen XM. Exosomal miRNAs: Biological Properties and Therapeutic Potential. Front Genet. 2012; 3: 56.  PMID 22529849
  7. Gong AY, Hu G, Zhou R, Liu J, and Chen XM. miR-221 controls expression of intercellular adhesion molecular-1 in epithelial cells in response to Cryptosporidium parvum infection. Int J Parasitol.2011, 397-403.  PMID 21236259 
  8. Yao H, Duan M, Hu G and Buch S. Platelet-derived growth factor B chain is a novel target gene of cocaine-mediated Notch1 signaling: implications for HIV-associated neurological disorders. J Neurosci. 2011, 31(35):12449-54.  PMID 21880906
  9. Hu G, Zhou R, Liu J, Gong AY and Chen XM. MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling-4 in biliary epithelial cells in response to Cryptosporidium parvuminfection. J Infect Dis. 2010, 202(1): 125-35.  PMID 20486857
  10. Hu G, Gong AY, Liu J, Zhou R, Deng and Chen XM. miR-221 suppresses ICAM-1 translation and regulates interferon-gamma-induced ICAM-1 expression in human cholangiocytes.  Am J Physiol Gastro Liver.2010, 298(4):G542-50.  PMID 20110463

Additional publications in PubMed

Dr. Hu's biographical information
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