Yunlong Huang, Ph.D.

Assistant ProfessorYuanlong Huang
Member Jialin Zheng, M.D.'s laboratory

Durham Research Center II, 3070
985930 Nebraska Medical Center
Omaha, NE 68198-5930

Phone: 402-559-5991

Keywords: neuroimmunology, drug development, neurogenesis and neurorepair

Research Interests
Representative Publications
Dr. Huang's biographical information

Research Interests

My goal is to develop new therapies to reduce neurotoxic injury and facilitate neurogenesis and repair processes in neurological diseases, including HIV-1 associated neurocognitive disorders, Alzheimer's disease, and Parkinson's Disease. My graduate and postdoctoral training was in neuroimmunology pursuing interdisciplinary research in pharmacology, immunology, neuroscience, and virology. My current research focuses on using animal models to study the cellular and molecular mechanisms that regulate the neuronal demise and regeneration in the neurodegenerative diseases where aberrant immune activation is considered a critical factor in disease pathobiology.

Ongoing projects include:

Representative Publications

Representative Publications:

  1. Xu P, Wang Y, Qin Z, Qiu L, Zhang M, Huang Y, Zheng JC. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692. PMID: 28735382
  2. Wang Y, Li Y, Zhao R, Wu B, Lanoha B, Tong Z, Peer J, Liu J, Xiong H, Huang Y, Zheng J. Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice. Brain Behav Immun. 2017 Nov;66:135-145. PMID: 28624534
  3. Li Y, Peer J, Zhao R, Xu Y, Wu B, Wang Y, Tian C, Huang Y, Zheng J. Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration. Transl Neurodegener. 2017 Apr 20;6:10. PMID: 28439409
  4. Wang K, Ye L, Lu H, Chen H, Zhang Y, Huang Y, Zheng JC. TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase. J Neuroinflammation. 2017 Apr 20;14(1):87. PMID: 28427419
  5. Wang Y, Huang Y*, Zhao L, Li Y, Zheng J*. Glutaminase 1 is essential for the differentiation, proliferation and survival of human neural progenitor cells. Stem Cells Dev. 2014 Jun 12 (*Co-corresponding author) PMID: 24923593
  6. Ye L, Huang Y*, Zhao L, Li Y, Sun L, Zhou Y, Qian G*, and Zheng J*. IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. J. Neurochem. 2013 Jun;125(6):897-908 (*Co-corresponding author) PMID: 23578284
  7. Zhao L, Huang Y*, Zheng, J*. STAT1 regulates human glutaminase 1 promoter activity through multiple binding sites in HIV-1 infected macrophages. PLOS One. 2013 Sep 24;8(9):e76581 (*Co-corresponding author)
  8. Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, Li Y, Jia B, Thoreson W, Ding W, Ding J, Zhao L, Wang Y, Wavrin KL, Duan S, Zheng J. (2012).CXCL12 Enhances Human Neural Progenitor Cell Survival through a CXCR7- and CXCR4- mediated Endocytotic Signaling Pathway. Stem Cells. 2012 Nov;30(11):2571-83. PMID: 22987307
  9. Huang Y*, Zhao L, Jia B, Wu L, Li Y, Curthoys N, Zheng J*. Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders. J Neurosci. 2011 Oct 19;31(42):15195-204 (Co-corresponding author) PMID: 22016553
  10. Huang Y, Walstrom A, Zhang L, Zhao Y, Cui M, Ye L, Zheng JC. Type I Interferons and Interferon Regulatory Factors Regulate TNF-Related Apoptosis-Inducing Ligand (TRAIL) in HIV-1-Infected Macrophages. PLoS ONE. 2009; 4(4): e5397. PMID: 19404407
  11. Huang Y, Erdmann N, Peng H, Herek S, Davis JS, Luo X, Ikezu T, Zheng J. TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation. J Immunol. 2006 Aug 15;177(4):2304-13. PMID: 16887991

Dr. Huang's biographical information
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