Yunlong Huang, Ph.D.

Assistant ProfessorYuanlong Huang
Member Jialin Zheng, M.D.'s laboratory

Durham Research Center II, 3070
985930 Nebraska Medical Center
Omaha, NE 68198-5930

Phone: 402-559-5991
Email

Keywords: neuroimmunology, drug development, neurogenesis and neurorepair


Research Interests
Representative Publications
Dr. Huang's biographical information


Research Interests

My research goal is to better understand how environmental factors, drugs, and viral infection cause neural injury so that new therapeutic approaches can be developed to intervene in the diseases such as HIV-1 associated neurocognitive disorders, Zika virus associated micrencephaly (an abnormally small brain), Alzheimer's disease, and Parkinson's Disease. A common theme in these diseases is immune activation and changes in cell-to-cell communication through extracellular vesicles (EVs). We have demonstrated that modulation of these processes is effective in viral inhibition and neural protection. Furthermore, we have also demonstrated that neural stem/progenitor cell is a cell type with immense therapeutic potential. Our current research focuses on using cellular and animal models to mimic neural injury in the brain. All of the new therapeutic approaches will be tested in these models for evaluation of efficacies.

Ongoing projects include:

 

Representative Publications

Representative Publications:

  1. Ma K, Deng X, Xia X, Fan Z, Qi X, Wang Y, Li Y, Ma Y, Chen Q, Peng H, Ding J, Li C, Huang Y*, Tian C*, Zheng JC*. Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons. (*, Co-corresponding authors) Translational Neurodegeneration. 2018 Nov 5;7:29. PMID: 30410751

  2. He M, Zhang H, Li Y, Wang G, Tang B, Zhao J, Huang Y*, Zheng JC*. Cathelicidin-derived antimicrobial peptides inhibit Zika virus through direct inactivation and interferon pathway. (*, Co-corresponding authors) Frontiers in Immunology. 2018;9:722. PMID: 29706959 

  3. Wu B, Liu J, Zhao R, Li Y, Peer J, Braun AL, Zhao L, Wang Y, Tong Z, Huang Y*, and Zheng J*. Glutaminase 1 Regulates the Release of Extracellular Vesicles during Neuroinflammation through Key Metabolic Intermediate Alpha-Ketoglutarate. (*, Co-corresponding authors) Journal of Neuroinflammation. 2018;15(1):79. PMID: 29540215

  4. Huang Y*, Li Y, Zhang H, Zhao R, Jing R, Xu Y, He M, Peer J, Kim YC, Luo J, Tong Z, and Zheng J*. Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869. (*, Co-corresponding authors) Cell discovery. 2018 Volume 4, issue 1.  1-16. https://doi.org/ 10.1038/s41421-018-0017-2. PMID: 29707233

  5. Peipei Xu, Yingchun Wang, Zhao Qin, Lisha Qiu, Ming Zhang, Yunlong Huang*, and Zheng J*. Combined medication of antiretroviral drugs tenofovir disoproxil fumarate, emtricitabine, and raltegravir reduces neural progenitor cell proliferation in vivo and in vitro. Journal of Neuroimmune Pharmacology. 2017 Dec;12(4):682-692. doi: 10.1007/s11481-017-9755-4. (*, Co-corresponding authors) PMID: 28735382 

  6. Xu P, Wang Y, Qin Z, Qiu L, Zhang M, Huang Y, Zheng JC. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692. PMID: 28735382

  7. Wang Y, Li Y, Zhao R, Wu B, Lanoha B, Tong Z, Peer J, Liu J, Xiong H, Huang Y, Zheng J. Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice. Brain Behav Immun. 2017 Nov;66:135-145. PMID: 28624534
  8. Li Y, Peer J, Zhao R, Xu Y, Wu B, Wang Y, Tian C, Huang Y, Zheng J. Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration. Transl Neurodegener. 2017 Apr 20;6:10. PMID: 28439409
  9. Wang K, Ye L, Lu H, Chen H, Zhang Y, Huang Y, Zheng JC. TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase. J Neuroinflammation. 2017 Apr 20;14(1):87. PMID: 28427419
  10. Wang Y, Huang Y*, Zhao L, Li Y, Zheng J*. Glutaminase 1 is essential for the differentiation, proliferation and survival of human neural progenitor cells. Stem Cells Dev. 2014 Jun 12 (*Co-corresponding author) PMID: 24923593
  11. Ye L, Huang Y*, Zhao L, Li Y, Sun L, Zhou Y, Qian G*, and Zheng J*. IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. J. Neurochem. 2013 Jun;125(6):897-908 (*Co-corresponding author) PMID: 23578284
  12. Zhao L, Huang Y*, Zheng, J*. STAT1 regulates human glutaminase 1 promoter activity through multiple binding sites in HIV-1 infected macrophages. PLOS One. 2013 Sep 24;8(9):e76581 (*Co-corresponding author)
  13. Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, Li Y, Jia B, Thoreson W, Ding W, Ding J, Zhao L, Wang Y, Wavrin KL, Duan S, Zheng J. (2012).CXCL12 Enhances Human Neural Progenitor Cell Survival through a CXCR7- and CXCR4- mediated Endocytotic Signaling Pathway. Stem Cells. 2012 Nov;30(11):2571-83. PMID: 22987307
  14. Huang Y*, Zhao L, Jia B, Wu L, Li Y, Curthoys N, Zheng J*. Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders. J Neurosci. 2011 Oct 19;31(42):15195-204 (Co-corresponding author) PMID: 22016553
  15. Huang Y, Walstrom A, Zhang L, Zhao Y, Cui M, Ye L, Zheng JC. Type I Interferons and Interferon Regulatory Factors Regulate TNF-Related Apoptosis-Inducing Ligand (TRAIL) in HIV-1-Infected Macrophages. PLoS ONE. 2009; 4(4): e5397. PMID: 19404407
  16. Huang Y, Erdmann N, Peng H, Herek S, Davis JS, Luo X, Ikezu T, Zheng J. TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation. J Immunol. 2006 Aug 15;177(4):2304-13. PMID: 16887991

Additional Publictions


Dr. Huang's biographical information
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