Georgette Kanmogne, PhD, MPH

ProfessorGeorgette Kanmogne

Durham Research Center 4044
985800 Nebraska Medical Center
Omaha, NE 68198-5800

402-559-4084
E-mail: Georgette Kanmogne

Keywords:

HIV, Blood-brain barrier, vascular biology

In the News
Research Interest
Long-range Goals
Representative Publications
Dr. Kanmogne's biographical information
Visit Dr. Kanmogne's laboratory

In the News

UNMC Today | April 23, 2012
Meet UNMC Distinguished Scientist Georgette Kanmogne, MD, MPH

UNMC Today | March 13, 2012
Dr. Kanmogne aims to improve AIDS care in Cameroon

YouTubeIn her own words, Dr. Kanmogne talks about her research in mechanisms of HIV-induced vascular dysfunction and neuroAIDs.

News Archives

Research Interest

HIV-1 invades the brain in the early stages of infection and productively infects brain mononuclear phagocytes (MPs: macrophages and microglia). The virus, secreted proteins “virotoxins” and inflammatory cytokines/chemokines produced by infected MPs are thought to induce neuronal dysfunction and HIV-associated dementia (HAD). To elucidate the pathogenesis of HAD, it is important to understand by what mechanisms HIV-1 invades the brain.

Our laboratory is currently using different experimental paradigms to decipher the mechanisms mediating in blood-brain barrier (BBB) dysfunction and virus invasion of the central nervous system (CNS) in HAD. These approaches include specific cytotoxic effects of HIV-1 and virotoxins on the brain endothelium (including functional alterations of cytoskeleton and tight junction proteins) leading to increased BBB permeability, role of chemokine receptors and events occurring within endothelial cells during interaction with HIV-1 infected cells.

Long-range Goals

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Representative Publications

  1. Bhargavan B, Kanmogne GD. Toll-Like Receptor-3 Mediates HIV-1-Induced Interleukin-6 Expression in the Human Brain Endothelium via TAK1 and JNK Pathways: Implications for Viral Neuropathogenesis. Mol Neurobiol. 2017 Nov 11. PMID: 29128906
  2. Teto G, Tagny CT, Mbanya D, Fonsah JY, Fokam J, Nchindap E, Kanmogne L, Njamnshi AK, Kanmogne GD. Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaoundé, Cameroon. Sci Rep. 2017 Oct 26;7(1):14136. PMID: 29074854
  3. Kanmogne GD, Qiu F, Ntone FE, Fonsah JY, Njamnshi DM, Kuate CT, Doh RF, Kengne AM, Tagny CT, Nchindap E, Kanmogne L, Mbanya D, Cherner M, Heaton RK, Njamnshi AK. Depressive symptoms in HIV-infected and seronegative control subjects in Cameroon: Effect of age, education and gender. PLoS One. 2017 Feb 23;12(2):e0171956. PMID: 28231258
  4. Fonsah JY, Njamnshi AK, Kouanfack C, Qiu F, Njamnshi DM, Tagny CT, Nchindap E, Kanmogne L, Mbanya D, Heaton R, Kanmogne GD. Adherence to Antiretroviral Therapy (ART) in Yaoundé-Cameroon: Association with Opportunistic Infections, Depression, ART Regimen and Side Effects. PLoS One. 2017 Jan 31;12(1):e0170893. PMID: 28141867
  5. Bhargavan B, Kanmogne GD. Differential Mechanisms of Inflammation and Endothelial Dysfunction by HIV-1 Subtype-B and Recombinant CRF02_AG Tat Proteins on Human Brain Microvascular Endothelial Cells: Implications for Viral Neuropathogenesis. Mol Neurobiol. 2017 Jan 27. PMID: 28127697
  6. Buch S, Chivero ET, Hoare J, Jumare J, Nakasujja N, Mudenda V, Paul R, Kanmogne GD, Sacktor N, Wood C, Royal W, Joseph J. Proceedings from the NIMH symposium on "NeuroAIDS in Africa: neurological and neuropsychiatric complications of HIV". J Neurovirol. 2016 Oct;22(5):699-70. PMID: 27473196 
  7. Woollard S, Bhargavan B, Yu F, and Kanmogne, G.D.  Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction J Cereb Blood Flow Metab 2014. Jun;34(6):1047-59. doi: 10.1038/jcbfm.2014.54. Epub 2014 Mar 26.  PMID 24667918
  8. Woollard SM, Li H, Singh S, Yu F, Kanmogne, G.D. HIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood-brain barrier interactions: modulatory role of CCR5. Retrovirology. 2014 Feb 26;11:20. doi: 10.1186/1742-4690-11-20.  PMID 24571616
  9. Li H., Singh S., Potula R., Persidsky Y., and Kanmogne, G.D. Dysregulation of claudin-5 in HIV-induced interstitial pneumonitis and lung vascular injury: protective role of PPAR-γ. Am J Resp Crit Care Med. 2014, July; 190(1): 85-97. PMC Journal – In Process.  PMID 22345580
  10. Kanmogne, G.D, Singh S, Roy U, Liu X, McMillan J, Gorantla S, Balkundi S, Smith N, Alnouti Y, Gautam N, Zhou Y, Poluektova L, Kabanov A, Bronich T, and Gendelman HE. Mononuclear
    phagocyte intercellular crosstalk facilitates transmission of cell targeted nanoformulated antiretroviral drugs to human brain endothelial cells. Int J Nanomedicine. 2012;7:2373-88. doi: 10.2147/IJN.S29454. Epub 2012 May 8. PMC Journal – in Process.
  11. Bressani R.B., Nowacek, A.S., Singh. S., Balkundi, S., Rabinow, B., McMillan, J., Gendelman, H.E., and Kanmogne, G.D. Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage. Nanotoxicology 2011; 5(4):592-605. PMC Journal – in Process.  PMID 21175298
  12. Kanmogne, G.D., Kuate CT, Cysique LA, Fonsah JY, Eta S, Doh R, Njamnshi DM, Nchindap E, Franklin DR Jr, Ellis RJ, McCutchan JA, Binam F, Mbanya D, Heaton RK, Njamnshi AK. HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon. BMC Neurol. 2010 July 13;10:60.  PMID 20626870
  13. Yang, B., Singh, S., and Kanmogne, G.D. Cross-talk between STAT1 and PI3K/AKT signaling in HIV-1-induced blood-brain barrier dysfunction: role of CCR5 and implications for viral neuropathogenesis. J Neurosci Res, 2010, 88 (14): 3090-101.  PMID 20568281
  14. Njamnshi AK, Bissek AC, Ongolo-Zogo P, Tabah EN, Lekoubou AZ, Yepnjio FN, Fonsah JY, Kuate CT, Angwafor SA, Dema F, Njamnshi DM, Kouanfack C, Djientcheu Vde P, Muna WF, Kanmogne G.D. Risk factors for HIV-associated neurocognitive disorders (HAND) in sub-Saharan Africa: the case of Yaoundé-Cameroon. J Neurol Sci. 2009; 285:149-53.  PMID 19631349
  15. Yang B, Akhter S, Chaudhuri A, Kanmogne GD. HIV-1gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling. Microvasc Res. 2009 77: 212-219. PMID 19103208
  16. Chaudhuri, A., Yang, B., Gendelman, H.E., Persidsky, Y., and Kanmogne, G.D. STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. Blood, 2008, 111(4): 2062-72.  PMID 18003888

Additional publications in PubMed.

Dr. Kanmogne's biographical information
Visit Dr. Kanmogne's laboratory
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