Bhavesh Kevadiya, Ph.D.

Bhavesh Kevadiya, Ph.D.Bhavesh_Kevadiya
Assistant Professor

 

HIV-1 Theranostics Laboratory
Durham Research Center-1 3030
985800 Nebraska Medical Center
Omaha, NE  68198-5800


 
Keywords:

Real time biodistribution, Long-acting antiretrovirals tracking, multimodal theranostic particles, nano-cocrystals, HIV-1 molecular imaging, synthesis and characterizations of nanomaterials, CRISPR, macrophages, transformative nanotechnology

 
Research Interests
On-going projects
Techniques
Publications
Dr. Kevadiya's biographical information
Dr. Kevadiya's lab

Research Interests

  1. Development of long acting antiretroviral drugs tracking through molecular imaging technologies
  2. Development of on viral delivery and molecular imaging tracking system of CRISPR technology
    Monocyte-derived macrophages (MDMs) as drug delivery system-cell based vehicles for nanoparticle
  3. Development of virus like nanoparticles for targeting antiretroviral therapy and monitoring by nuclear medicine and molecular imaging technology
  4. Nano-cocrystal strategy for multi-drug antiretroviral therapy
  5. Synthesis of radiolabeled nanoparticles for nuclear medicine and molecular imaging technology for diagnostics as well as a therapeutic purpose

On-going projects

  1. Development of virus like nanoparticles for targeting antiretroviral therapy and monitoring by nuclear medicine and molecular imaging technology
  2. Development of novel drugs co-crystals nanoparticle with for monitoring drug biodistribution;
  3. In vitro and In vivo nanoART biodistribution assessment by dual modal SPECT/CT-MRI tri-modal molecular imaging with bismuth-cobalt ferrite nanoparticles
  4. Sustained release of hydrophilic antiretroviral drug by using layered nanomaterials

Techniques

Publications

  1. Machhi J, Herskovitz J, Senan AM, Dutta D, Nath B, Oleynikov MD, Blomberg WR, Meigs DD, Hasan M, Patel M, Kline P, Chang RC, Chang L, Gendelman HE, Kevadiya BD. The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections. J Neuroimmune Pharmacol. 2020 Jul 21;. doi: 10.1007/s11481-020-09944-5. [Epub ahead of print] Review. PubMed PMID: 32696264; PubMed Central PMCID: PMC7373339.
  2. Patel TK, Barvaliya M, Kevadiya BD, Patel PB, Bhalla HL. Does Adding of Hydroxychloroquine to the Standard Care Provide any Benefit in Reducing the Mortality among COVID-19 Patients?: a Systematic Review. J Neuroimmune Pharmacol. 2020 Jun 30;. doi: 10.1007/s11481-020-09940-9. [Epub ahead of print] PubMed PMID: 32607690; PubMed Central PMCID: PMC7326306.
  3. Patel TK, Barvaliya M, Kevadiya BD, Patel PB, Bhalla HL. Does Adding of Hydroxychloroquine to the Standard Care Provide any Benefit in Reducing the Mortality among COVID-19 Patients?: a Systematic Review. J Neuroimmune Pharmacol. 2020 Jun 9;. doi: 10.1007/s11481-020-09930-x. [Epub ahead of print] Review. PubMed PMID: 32519281; PubMed Central PMCID: PMC7280684.
  4. Machhi J, Kevadiya BD, Muhammad IK, Herskovitz J, Olson KE, Mosley RL, Gendelman HE. Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders. Mol Neurodegener. 2020 Jun 5;15(1):32. doi: 10.1186/s13024-020-00375-7. Review. PubMed PMID: 32503641; PubMed Central PMCID: PMC7275301.
  5. Acharya A, Kevadiya BD, Gendelman HE, Byrareddy SN. SARS-CoV-2 Infection Leads to Neurological Dysfunction. J Neuroimmune Pharmacol. 2020 Jun;15(2):167-173. doi: 10.1007/s11481-020-09924-9. Epub 2020 May 23. PubMed PMID: 32447746; PubMed Central PMCID: PMC7244399.
  6. Primavera R, Kevadiya BD, Swaminathan G, Wilson RJ, De Pascale A, Decuzzi P, Thakor AS. Emerging Nano- and Micro-Technologies Used in the Treatment of Type-1 Diabetes. Nanomaterials (Basel). 2020 Apr 20;10(4). doi: 10.3390/nano10040789. Review. PubMed PMID: 32325974; PubMed Central PMCID: PMC7221526.
  7. Dash PK, Kevadiya BD, Su H, Banoub MG, Gendelman HE. Pathways towards human immunodeficiency virus elimination. EBioMedicine. 2020 Mar;53:102667. doi: 10.1016/j.ebiom.2020.102667. Epub 2020 Feb 27. Review. PubMed PMID: 32114397; PubMed Central PMCID: PMC7047153.
  8. Mukadam IZ, Machhi J, Herskovitz J, Hasan M, Oleynikov MD, Blomberg WR, Svechkarev D, Mohs AM, Zhou Y, Dash P, McMillan J, Gorantla S, Garrison J, Gendelman HE, Kevadiya BD. Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking. Biomaterials. 2020 Feb;231:119669. doi: 10.1016/j.biomaterials.2019.119669. Epub 2019 Dec 7. PubMed PMID: 31865227; PubMed Central PMCID: PMC7334833.
  9. Acharya D, Rane S, Bohora S, Kevadiya H. Incidence, clinical, electrophysiological characteristics and outcomes of patients with Wolff-Parkinson-White syndrome and atrial fibrillation. Indian Pacing Electrophysiol J. 2020 Jan - Feb;20(1):3-7. doi: 10.1016/j.ipej.2019.12.015. Epub 2020 Jan 13. PubMed PMID: 31945418; PubMed Central PMCID: PMC6994406.
  10. Kevadiya BD, Ottemann B, Mukadam IZ, Castellanos L, Sikora K, Hilaire JR, Machhi J, Herskovitz J, Soni D, Hasan M, Zhang W, Anandakumar S, Garrison J, McMillan J, Edagwa B, Mosley RL, Vachet RW, Gendelman HE. Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues. Theranostics. 2020;10(2):630-656. doi: 10.7150/thno.39847. eCollection 2020. PubMed PMID: 31903142; PubMed Central PMCID: PMC6929995.
  11. Kevadiya BD, Ottemann BM, Thomas MB, Mukadam I, Nigam S, McMillan J, Gorantla S, Bronich TK, Edagwa B, Gendelman HE. Neurotheranostics as personalized medicines. Adv Drug Deliv Rev. 2019 Aug;148:252-289. doi: 10.1016/j.addr.2018.10.011. Epub 2018 Oct 26. Review. PubMed PMID: 30421721; PubMed Central PMCID: PMC6486471.
  12. Kevadiya BD, Chen L, Zhang L, Thomas MB, Davé RN. Fenofibrate Nanocrystal Composite Microparticles for Intestine-Specific Oral Drug Delivery System. Pharmaceuticals (Basel). 2019 Jul 16;12(3). doi: 10.3390/ph12030109. PubMed PMID: 31315263; PubMed Central PMCID: PMC6789785.
  13. S K, Rama Pawar R, D Kevadiya B, C Bajaj H. Synthesis of Saponite Based Nanocomposites to Improve the Controlled Oral Drug Release of Model Drug Quinine Hydrochloride Dihydrate. Pharmaceuticals (Basel). 2019 Jul 10;12(3). doi: 10.3390/ph12030105. PubMed PMID: 31295860; PubMed Central PMCID: PMC6789514.
  14. Gendelman HE, McMillan J, Bade AN, Edagwa B, Kevadiya BD. The Promise of Long-Acting Antiretroviral Therapies: From Need to Manufacture. Trends Microbiol. 2019 Jul;27(7):593-606. doi: 10.1016/j.tim.2019.02.009. Epub 2019 Apr 10. Review. PubMed PMID: 30981593; PubMed Central PMCID: PMC6571075.
  15. Tomitaka A, Kaushik A, Kevadiya BD, Mukadam I, Gendelman HE, Khalili K, Liu G, Nair M. Surface-engineered multimodal magnetic nanoparticles to manage CNS diseases. Drug Discov Today. 2019 Mar;24(3):873-882. doi: 10.1016/j.drudis.2019.01.006. Epub 2019 Jan 17. Review. PubMed PMID: 30660756; PubMed Central PMCID: PMC7405805.
  16. Saminathan P, Kevadiya BD, Marker DF, Gendelman HE, Gorantla S, Gelbard HA. Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages. J Neuroimmune Pharmacol. 2019 Mar;14(1):44-51. doi: 10.1007/s11481-018-09829-8. Epub 2019 Jan 7. Review. PubMed PMID: 30617749; PubMed Central PMCID: PMC6391203.
  17. Ottemann BM, Helmink AJ, Zhang W, Mukadam I, Woldstad C, Hilaire JR, Liu Y, McMillan JM, Edagwa BJ, Mosley RL, Garrison JC, Kevadiya BD, Gendelman HE. Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities. Biomaterials. 2018 Dec;185:174-193. doi: 10.1016/j.biomaterials.2018.09.018. Epub 2018 Sep 14. PubMed PMID: 30245386; PubMed Central PMCID: PMC6556898.
  18. Kevadiya BD, Zhang L, Davé RN. Sustained Release of Poorly Water-Soluble Drug from Hydrophilic Polymeric Film Sandwiched Between Hydrophobic Layers. AAPS PharmSciTech. 2018 Aug;19(6):2572-2584. doi: 10.1208/s12249-018-1089-x. Epub 2018 Jun 14. PubMed PMID: 29948990.
  19. Kevadiya BD, Barvaliya M, Zhang L, Anovadiya A, Brahmbhatt H, Paul P, Tripathi C. Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement. Bioengineering (Basel). 2018 Feb 13;5(1). doi: 10.3390/bioengineering5010016. PubMed PMID: 29438297; PubMed Central PMCID: PMC5874882.
  20. Kevadiya BD, Woldstad C, Ottemann BM, Dash P, Sajja BR, Lamberty B, Morsey B, Kocher T, Dutta R, Bade AN, Liu Y, Callen SE, Fox HS, Byrareddy SN, McMillan JM, Bronich TK, Edagwa BJ, Boska MD, Gendelman HE. Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution. Theranostics. 2018;8(1):256-276. doi: 10.7150/thno.22764. eCollection 2018. PubMed PMID: 29290806; PubMed Central PMCID: PMC5743473.
  21. Kevadiya BD, Bade AN, Woldstad C, Edagwa BJ, McMillan JM, Sajja BR, Boska MD, Gendelman HE. Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging. Acta Biomater. 2017 Feb;49:507-520. doi: 10.1016/j.actbio.2016.11.071. Epub 2016 Dec 1. PubMed PMID: 27916740; PubMed Central PMCID: PMC5501313.
  22. Kevadiya BD, Rajkumar S, Bajaj HC, Chettiar SS, Gosai K, Brahmbhatt H, Bhatt AS, Barvaliya YK, Dave GS, Kothari RK. Biodegradable gelatin-ciprofloxacin-montmorillonite composite hydrogels for controlled drug release and wound dressing application. Colloids Surf B Biointerfaces. 2014 Oct 1;122:175-183. doi: 10.1016/j.colsurfb.2014.06.051. Epub 2014 Jun 30. PubMed PMID: 25033437.
  23. Kevadiya BD, Chettiar SS, Rajkumar S, Bajaj HC, Gosai KA, Brahmbhatt H. Evaluation of clay/poly (L-lactide) microcomposites as anticancer drug, 6-mercaptopurine reservoir through in vitro cytotoxicity, oxidative stress markers and in vivo pharmacokinetics. Colloids Surf B Biointerfaces. 2013 Dec 1;112:400-7. doi: 10.1016/j.colsurfb.2013.07.008. Epub 2013 Aug 19. PubMed PMID: 24036475.
  24. Kevadiya BD, Patel TK, Patel PB, Rajkumar S, Tripathi CB, Bajaj HC. Montmorillonite Poly-L-Lactide Microcomposites of Procainamide for controlled drug delivery: In vitro and In vivo evaluation. Indian J Pharm Sci. 2013 Nov;75(6):722-6. PubMed PMID: 24591748; PubMed Central PMCID: PMC3928737.
  25. Pawar RR, Kevadiya BD, Brahmbhatt H, Bajaj HC. Template free synthesis of mesoporous hectorites: efficient host for pH responsive drug delivery. Int J Pharm. 2013 Mar 25;446(1-2):145-52. doi: 10.1016/j.ijpharm.2013.02.021. Epub 2013 Feb 16. PubMed PMID: 23419664.
  26. Kevadiya BD, Thumbar RP, Rajput MM, Rajkumar S, Brambhatt H, Joshi GV, Dangi GP, Mody HM, Gadhia PK, Bajaj HC. Montmorillonite/poly-(ε-caprolactone) composites as versatile layered material: reservoirs for anticancer drug and controlled release property. Eur J Pharm Sci. 2012 Aug 30;47(1):265-72. doi: 10.1016/j.ejps.2012.04.009. Epub 2012 Apr 16. PubMed PMID: 22525435.
  27. Kevadiya BD, Patel TA, Jhala DD, Thumbar RP, Brahmbhatt H, Pandya MP, Rajkumar S, Jena PK, Joshi GV, Gadhia PK, Tripathi CB, Bajaj HC. Layered inorganic nanocomposites: a promising carrier for 5-fluorouracil (5-FU). Eur J Pharm Biopharm. 2012 May;81(1):91-101. doi: 10.1016/j.ejpb.2012.01.004. Epub 2012 Jan 16. PubMed PMID: 22269936.
  28. Kevadiya BD, Patel HA, Joshi GV, Abdi SH, Bajaj HC. Montmorillonite-Alginate Composites as a Drug delivery System: Intercalation and In vitro Release of Diclofenac sodium. Indian J Pharm Sci. 2010 Nov;72(6):732-7. doi: 10.4103/0250-474X.84582. PubMed PMID: 21969745; PubMed Central PMCID: PMC3178974.
  29. Joshi GV, Kevadiya BD, Bajaj HC. Controlled release formulation of ranitidine-containing montmorillonite and Eudragit E-100. Drug Dev Ind Pharm. 2010 Sep;36(9):1046-53. doi: 10.3109/03639041003642073. PubMed PMID: 20545505.
  30. Kevadiya BD, Joshi GV, Patel HA, Ingole PG, Mody HM, Bajaj HC. Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6. J Biomater Appl. 2010 Aug;25(2):161-77. doi: 10.1177/0885328209344003. Epub 2009 Sep 8. PubMed PMID: 19737810.
  31. Kevadiya BD, Joshi GV, Bajaj HC. Layered bionanocomposites as carrier for procainamide. Int J Pharm. 2010 Mar 30;388(1-2):280-6. doi: 10.1016/j.ijpharm.2010.01.002. Epub 2010 Jan 13. PubMed PMID: 20074630.
  32. Joshi GV, Kevadiya BD, Patel HA, Bajaj HC, Jasra RV. Montmorillonite as a drug delivery system: intercalation and in vitro release of timolol maleate. Int J Pharm. 2009 Jun 5;374(1-2):53-7. doi: 10.1016/j.ijpharm.2009.03.004. Epub 2009 Mar 19. PubMed PMID: 19446759.
  33. BD Kevadiya, SS Chettiar, S Rajkumar, HC Bajaj, H Brahmbhatt, ...Evaluation of Montmorillonite/Poly (L-Lactide) microcomposite spheres as ambidextrous reservoirs for controlled release of Capecitabine (Xeloda) and assessment of cell …Composites science and technology 90, 193-201, 2014.
  34. BD Kevadiya, S Rajkumar, HC Bajaj, Application and evaluation of layered silicate–chitosan composites for site specific delivery of diclofenac, Biocybernetics and Biomedical Engineering 35 (2), 120-127, 2015.

Additional publications in google scholar.

Book Chapters:

  1. D. Kevadiya and H.C. Bajaj, The layered silicate, montmorillonite (MMT) as a drug delivery carrier. Key Engineering Materials, 571 (2013), 111.

Patents:

  1. Pandya, B. D. Kevadiya, S. Rajkumar. Formulation of 6-benzylaminopurine montmorillonite alginate (6-BAP-MMT-AL) microcomposites for sustained release [Provisional no.1977/MUM/2014] - Indian Patent.
  2. Gendelman HE, Herskovitz J. Mahmudul H, Kevadiya DB. Virus like particles and methods of use thereof; WO:2020/160418;/ PCT/US2020/016126

Dr. Kevadiya's biographical information
Dr. Kevadiya's Lab

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