Daniel Monaghan, Ph.D.

Professordaniel monaghan

Durham Research Center 3052
985800 Nebraska Medical Center
Omaha, NE 68198-5800

Phone: 402-559-7196
E-mail:  Daniel Monaghan




Research Interests
Representative Publications
Dr. Monaghan's biographical information
Visit Dr. Monaghan's laboratory


daniel monaghan In his own words - Dr. Monaghan talks about his research and training our next generation of scientists.

In the news:  Students honored at biomedical research forum. Kiran Sapkota, graduate student in Dr. Monaghan's lab, wins first place poster presentation.

Research Interests

Top of page


Representative Publications

  1. Chopra DA, Sapkota K, Irvine MW, Fang G, Jane DE, Monaghan DT, Dravid SM. A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors. Sci Rep. 2017 Jul 31;7(1):693. PMID: 28761055.  PMCID: PMC5537304 
  2. Sapkota K, Irvine MW, Fang G, Burnell ES, Bannister N, Volianskis A, Culley GR, Dravid SM, Collingridge GL, Jane DE, Monaghan DT. Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives. Neuropharmacology. 2017 Oct;125:64-79. PMID: 28709671. PMCID: PMC5623084
  3. Gupta SC, Ravikrishnan A, Liu J, Mao Z, Pavuluri R, Hillman BG, Gandhi PJ, Stairs DJ, Li M, Ugale RR, Monaghan DT, Dravid SM. The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function. Sci Rep. 2016 Dec 6;6:38321. PMID: 27922130. PMCID: PMC5138829 
  4. France G, Fernández-Fernández D, Burnell ES, Irvine MW, Monaghan DT, Jane DE, Bortolotto ZA, Collingridge GL, Volianskis A. Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus. Neuropharmacology. 2017 Jan;112(Pt A):76-83. PMID: 27523302.  PMCID: PMC5084684 
  5. Sapkota K, Mao Z, Synowicki P, Lieber D, Liu M, Ikezu T, Gautam V, Monaghan DT. GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia. J Pharmacol Exp Ther. 2016 Mar;356(3):702-11. PMID: 26675679. PMCID: PMC4767398 
  6. Irvine MW, Fang G, Eaves R, Mayo-Martin MB, Burnell ES, Costa BM, Culley GR, Volianskis A, Collingridge GL, Monaghan DT, Jane DE. Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators. Synthesis (Stuttg). 2015 Jun 1;47(11):1593-1610. PMID: 26568642. PMCID: PMC4641328
  7. Chopra DA, Monaghan DT, Dravid SM. Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu. Mol Pharmacol. 2015 Oct;88(4):650-9. PMID: 26162866. PMCID: PMC4576688 
  8. Gautam V, Trinidad JC, Rimerman RA, Costa BM, Burlingame AL, Monaghan DT. Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D. Neuropharmacology. 2013 Nov;74:96-107. PMID: 2363943. PMCID: PMC3855079 
  9. Monaghan DT, Irvine MW, Costa BM, Fang G, Jane DE. Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators. Neurochem Int. 2012 Sep;61(4):581-92. PMID: 22269804. PMCID: PMC3360989
  10. Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Laube B, Jane DE, Monaghan DT. Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid. Neuropharmacology. 2012 Mar;62(4):1730-6. PMID: 22155206. PMCID: PMC3269548
  11. Costa BM, Irvine MW, Feng G, Eaves RJ, Mayo-Martin MB, Skifter DA, Jane DE, Monaghan DT. A novel family of negative and positive allosteric modulators of NMDA receptors. J. Pharmacol Exp Ther 2010.  PMID 20858708
  12. Talbot JN, Skifter DA, Bianchi E, Monaghan DT, Toews ML, Murrin LC. Regulation of mu opioid receptor internalization by the scaffold protein RanBPM Neurosci Letter 2009 466F(3):154-8.  PMID 19788913
  13. Costa BM, Feng B, Tsintsadze TS, Morley RM, Irvine MW, Tsintsadze V, Lozovaya NA, Jane DE, Monaghan DT. N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. J Pharmacol Exp Ther. 2009, 331(2):618-26.  PMID 19684242
  14. Whitney NP, Peng H, Erdmann NB, Tian C, Monaghan DT, Zheng JC. Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons. FASEB J. 2008 Aug;22(8):2888-900.  PMID 18403631
  15. Brothwell SL, Barber JL, Monaghan, DT, Jane DE, Gibb AJ, and Jones S. NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurons. J. Physiology (2008) 586 739-750.  PMID 18033813
  16. Whitney NP, Peng H, Erdmann NB, Monaghan DT, and Zheng JC. Activation of AMPA receptors with Q/R-unedited GluR2 induces the differentiation of human neural progenitor cells to neurons. FASEB (2008).22: 2888-2900.  PMID 18403631
  17. Maurice T, Meunier J, Feng B, Ieni J, Monaghan DT. Interaction with s1 Protein, but not NMDA Receptor, is Involved in the Pharmacological Activity of Donepezil J. Pharmacol. Experimental Therapeutics (2006) 317 606-614.  PMID 16397090
  18. Bean L, Zheng H, Patel KP, and Monaghan DT. Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain. Brain Research (2006) 1115 217-222.  PMID 16938282
  19. Lozovaya NA, Grebenyuk SE, Tsintsadze TS, Feng B, Monaghan DT, and Krishtal OA. Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ‘superslow’ afterburst EPSC in rat hippocampus. J. Physiology (2004) 558 (2) 451-463.  PMID 15146049
  20. Feng B, Tse HW,  Skifter DA, Morley R, Jane DE, and Monaghan DT.  Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid. British Journal of Pharmacology (2004) 141:508-516.  PMID 14718249

Additional Publications on PubMed.


Dr. Monaghan's biographical information
Visit Dr. Monaghan's laboratory
Top of page