- Primary Faculty
- Aditya Bade, PhD
- Keshore Bidasee, PhD
- Shilpa Buch, PhD
- Siddappa Byrareddy, PhD
- Prasanta Dash, PhD
- Benson Edagwa, PhD
- Howard E. Gendelman, MD
- Santhi Gorantla, PhD
- Channabasavaiah B. Gurumurthy, PhD
- Guoku Hu, PhD
- Yunlong Huang, PhD
- Georgette Kanmogne, PhD, MPH
- Jianuo Liu, PhD
- David McMillan, PhD
- JoEllyn McMillan, PhD
- Daniel Monaghan, PhD
- R. Lee Mosley, PhD
- Peter Oldenburg, PhD
- Palsamy Periyasamy, PhD
- Larisa Poluektova, MD, PhD
- Susmita Sil, PhD
- Huangui Xiong, MD, PhD
- Instructors
- Postdoctoral Fellows and Senior Research Associates
- Administrative and Lab Support Staff
- Meet our faculty - in their own words
- Courtesy Faculty
- Emeritus Faculty and In Memory
- Visiting Faculty
- Neuroscience Faculty
Research Goals
Funding
Techniques used in the lab
Personnel
Return to Dr. Monaghan's home page
Dr. Monaghan's biographical information
Lab phone: 402-559-7132
Research Goals
- Development of subtype-selective glutamate receptor antagonists to determine the roles of individual receptors in brain function and brain disorders
- Determine the intracellular signaling pathways by which NMDA receptors regulate neuronal cell function
Funding
Development and Pharmacology of Positive Allosteric Modulators of NMDA Receptors
PI: D. Monaghan
Source: NIH/NIMH 4R01 MH060252
The grant Development and Pharmacology of Positive Allosteric Modulators of NMDA Receptors supports the development of novel NMDA receptor antagonists that are designed to block the function of distinct subtypes of NMDA receptors. The projects uses a combination of medicinal chemistry, molecular modeling, molecular biology, and electrophysiology to design, make and test new compounds that may be of use in treating Alzheimer's, Huntington's, Parkinsons disease as well as stroke, schizophrenia, and neuropathic pain.
Glutamate Delat-1 Receptor and Metabotropic Glutamate Receptor Interaction
PI: S. Dravid; C-I: D. Monaghan
Source: National Science Foundation NSF1456818
The objective of this grant is to characterize the protein-protein interactions between Delta-1 receptors and metabotropic glutamate receptors and their effects on receptor signaling.
NMDA receptor subtypes in basal ganglia
Co-I: D. Monaghan
Source: Subcontract with Creighton University
The Molecular Biology of Neurosensory Systems
PI: S. Smith; Co-I: D. Monaghan
5P30GM110768-03
The goal of this project is to develop a conditional mouse model to study the role of Nr2e3 in adult cone and rod photoreceptors and to identify genetic and direct interacting factors that work with Nr2e3 to influence photoreceptor cell development.
Techniques used in laboratory
- Molecular biology (construction of cDNA point mutations and chimeras, PCR, cRNA synthesis, yeast two-hybrid)
- Neuroanatomy and neuropharmacology (quantitative receptor autoradiography, in situ hybridization, immunohistochemistry, radioligand binding)
- Protein chemistry (immunoprecipitation, Western blotting, protein phosphorylation, two dimensional peptide mapping)
- Electrophysiology (two electrode voltage clamp of frog oocytes; hippocampal extracellular recordings, patch-clamp of brain cells in hippocampal slices, dynamic calcium imaging)
- Cell culture (primary cells and brain tissue slice cultures)
- Molecular modeling (homology receptor modeling and drug-receptor docking)
Personnel
Tyler Miller |
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Kiran Sapkota |
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Dr. Monaghan's home page
Dr. Monaghan's biographical information
Top of page
- Primary Faculty
- Aditya Bade, PhD
- Keshore Bidasee, PhD
- Shilpa Buch, PhD
- Siddappa Byrareddy, PhD
- Prasanta Dash, PhD
- Benson Edagwa, PhD
- Howard E. Gendelman, MD
- Santhi Gorantla, PhD
- Channabasavaiah B. Gurumurthy, PhD
- Guoku Hu, PhD
- Yunlong Huang, PhD
- Georgette Kanmogne, PhD, MPH
- Jianuo Liu, PhD
- David McMillan, PhD
- JoEllyn McMillan, PhD
- Daniel Monaghan, PhD
- R. Lee Mosley, PhD
- Peter Oldenburg, PhD
- Palsamy Periyasamy, PhD
- Larisa Poluektova, MD, PhD
- Susmita Sil, PhD
- Huangui Xiong, MD, PhD
- Instructors
- Postdoctoral Fellows and Senior Research Associates
- Administrative and Lab Support Staff
- Meet our faculty - in their own words
- Courtesy Faculty
- Emeritus Faculty and In Memory
- Visiting Faculty
- Neuroscience Faculty