Larisa Poluektova, MD, PhD

Co-Director for Translational Mouse Model Core FacilitylPoluektova
Co-Director for PAMM 912/PHAR902:
Human-Specific Disease Modeling in Mice


Durham Research Center, Room 8015
985880 Nebraska Medical Center
Omaha, NE 68198-5880

Phone: 402-559-8926
E-mail: Larisa Poluektova

Keywords: hematopoietic stem cells, murine models for HIV-1, HIV-1 vaccines

In the news
Research Interests
Representative Publications
Dr. Poluektova's biographical information
Visit Dr. Poluektova's laboratory

In the news

UNMC Today | September 26, 2019
Landscaped corner transforms med center's southern entrance

UNMC Today | February 6, 2018
Chemically modified drug shows promise for HIV treatment, elimination

UNMC Today, January 12, 2017
Distinguished Scientist Larisa Poluektova, MD, PhD

UNMC Today, July 20, 2012
UNMC team develops long-acting nanomedicines for HIV infection

UNMC Today, July 13, 2012
Of mice and men

Research Interests

HIV-1 pathogenesis, therapeutics and vaccines, humanized mice for translational research, stem cell transplantation. The long range goals are to development small animal models to study the pathogenesis of human-specific viral co-infection - HIV-1 and HCV/HBV.

Visit UNMC Translational Mouse Model Core Facility.

Representative Publications

  1. Li W, Gorantla S, Gendelman HE, Poluektova LY. Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains. Dis Model Mech. 2017 Dec 19;10(12):1489-1502. PMID: 29084769.
  2. Singh VB, Singh MV, Piekna-Przybylska D, Gorantla S, Poluektova LY, Maggirwar SB. Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection. Sci Rep. 2017 Aug 29;7(1):9578. PMID: 28852071. PMCID: PMC5575104 
  3. Araínga M, Edagwa B, Mosley RL, Poluektova LY, Gorantla S, Gendelman HE. A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy. Retrovirology. 2017 Mar 9;14(1):17. PMID: 28279181; PubMed Central PMCID: PMC5345240.
  4. Ganesan M, Poluektova LY, Tuma DJ, Kharbanda KK, Osna NA. Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18. Alcohol Clin Exp Res. 2016 Nov;40(11):2329-233. PMID: 27716962.
  5. Quadros RM, Poluektova LY, Gurumurthy CB. Simple and reliable genotyping protocol for mouse Prkdc(SCID) mutation. J Immunol Methods. 2016 Apr;431:602.  PMID: 26851521.  PMCID: PMC4818111 
  6. Zhang J, Garrison JC, Poluektova LY, Bronich TK, Osna NA. Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics. Biomaterials. 2015 Nov;70:37-47. doi: 10.1016/j.biomaterials.2015.08.014. Epub 2015 Aug 8. PMID:26298393
  7. Osna NA, Kharbanda KK, Sun Y, Simpson RL, Poluektova LE, Ganesan M, Wisecarver JL, Mercer DF. (2014) Ethanol affects hepatitis C pathogenesis: humanized SCID Alb-uPA mouse model. Biochem Biophys Res Commun 450(1): 773-6. PMID: 24953695
  8. Gutti TL, Knibbe JS, Makarov E, Zhang J, Yannam GR, Gorantla S, Sun Y, Mercer DF, Suemizu H, Wisecarver JL, Osna NA, Bronich TK, Poluektova LY. (2014) Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice. Am J Pathol 184(1): 101-9. PMID: 24200850
  9. Zhang J, Mulvenon A, Makarov E, Wagoner J, Knibbe J, Kim JO, Osna N, Bronich TK, Poluektova LY. (2013) Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection. Biomaterials 34(15): 3846-57. PMID: 23403120
  10. Dash PK, Gendelman HE, Roy U, Balkundi S, Alnouti Y, Mosley RL, Gelbard HA, McMillan J, Gorantla S, Poluektova LY. (2012) Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice. AIDS 26(17): 2135-44. PMID: 22824628


Additional Publications on PubMed.

Dr. Poluektova's biographical information
Visit Dr. Poluektova's laboratory
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