Larisa Poluektova, M.D., Ph.D.

Professor
Co-Director for Translational Mouse Model Core FacilitylPoluektova

Durham Research Center, Room 8015
985880 Nebraska Medical Center
Omaha, NE 68198-5880

Phone: 402-559-8926
E-mail: Larisa Poluektova

Keywords: hematopoietic stem cells, murine models for HIV-1, HIV-1 vaccines


In the news
Research Interests
Representative Publications
Dr. Poluektova's biographical information
Visit Dr. Poluektova's laboratory


In the news

UNMC Today, January 12, 2017
Distinguished Scientist Larisa Poluektova, M.D., Ph.D.

UNMC Today, July 20, 2012
UNMC team develops long-acting nanomedicines for HIV infection

UNMC Today, July 13, 2012
Of mice and men


Research Interests

HIV-1 pathogenesis, therapeutics and vaccines, humanized mice for translational research, stem cell transplantation. The long range goals are to development small animal models to study the pathogenesis of human-specific viral co-infection - HIV-1 and HCV/HBV.

Visit UNMC Translational Mouse Model Core Facility.


Representative Publications

  1. Planque SA, Mitsuda Y, Chitsazzadeh V, Gorantla S, Poluektova L, Nishiyama Y, Ochsenbauer C, Morris MK, Sapparapu G, Hanson CV, Massey RJ, Paul S. (2014) Deficient synthesis of class-switched, HIV-neutralizing antibodies to the CD4+ binding site and correction by electrophilic gp120 immunogen. AIDS [Epub ahead of print]. PMID: 25022597

  2. Osna NA, Kharbanda KK, Sun Y, Simpson RL, Poluektova LE, Ganesan M, Wisecarver JL, Mercer DF. (2014) Ethanol affects hepatitis C pathogenesis: humanized SCID Alb-uPA mouse model. Biochem Biophys Res Commun 450(1): 773-6. PMID: 24953695

  3. Gutti TL, Knibbe JS, Makarov E, Zhang J, Yannam GR, Gorantla S, Sun Y, Mercer DF, Suemizu H, Wisecarver JL, Osna NA, Bronich TK, Poluektova LY. (2014) Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice. Am J Pathol 184(1): 101-9. PMID: 24200850

  4. Gerson T, Makarov E, Senanayake TH, Gorantla S, Poluektova LY, Vinogradov SV. (2014) Nano-NRTIs demonstrate low neurotoxicity and high antiviral activity against HIV infection in the brain. Nanomedicine 10(1): 177-85. PMID: 23845925

  5. Bade AN, Zhou B, Epstein AA, Gorantla S, Poluektova LY, Luo J, Gendelman HE, Boska MD, Liu Y. (2013) Improved visualization of neuronal injury following glial activation by manganese enhanced MRI. J Neuroimmune Pharmacol 8(4): 1027-36. PMID:23729245

  6. Epstein AA, Narayanasamy P, Dash PK, High R, Bathena SP, Gorantla S, Poluektova LY, Alnouti Y, Gendelman HE, Boska MD. (2013) Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection. J Neuroimmune Pharmacol 8(5): 1224-38. PMID: 23702663

  7. Zhang J, Mulvenon A, Makarov E, Wagoner J, Knibbe J, Kim JO, Osna N, Bronich TK, Poluektova LY. (2013) Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection. Biomaterials 34(15): 3846-57. PMID: 23403120

  8. Dash PK, Gendelman HE, Roy U, Balkundi S, Alnouti Y, Mosley RL, Gelbard HA, McMillan J, Gorantla S, Poluektova LY. (2012) Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice. AIDS 26(17): 2135-44. PMID: 22824628

  9. Roy U, McMillan J, Alnouti Y, Gautum N, Smith N, Balkundi S, Dash P, Gorantla S, Martinez-Skinner A, Meza J, Kanmogne G, Swindells S, Cohen SM, Mosley RL, Poluektova L, Gendelman HE. (2012) Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice. J Infect Dis 206(10): 1577-88. PMID: 22811299

  10. Oberoi HS, Nukolova NV, Laquer FC, Poluektova LY, Huang J, Alnouti Y, Yokohira M, Arnold LL, Kabanov AV, Cohen SM, Bronich TK. (2012) Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice. Int J Nanomedicine 7:2557-71. PMID: 22745537

Additional Publications on PubMed.


Dr. Poluektova's biographical information
Visit Dr. Poluektova's laboratory
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