Dr. Wilson's Laboratory

Collaborators
Funding
Techniques used in the lab
Personnel
Dr. Wilson's home page


Collaborators

Max Kurz, Ph.D., Munroe-Meyer Institute, UNMC
Howard Gendelman, M.D., Department of Pharmacology and Experimental Neuroscience, UNMC
Christopher Kratochvil, M.D., Department of Psychiatry, UNMC
Deepak Madhavan, M.D., Department of Neurological Sciences, UNMC
R. Lee Mosley, Ph.D., ,Department of Pharmacology and Experimental Neuroscience, UNMC
Howard Fox, M.D., Ph.D., Department of Pharmacology and Experimental Neuroscience, UNMC
Susan Swindells, M.B.B.S., Department of Internal Medicine, UNMC
Matthew White, M.D., Department of Radiology, UNMC
Vince Calhoun, Ph.D., The Mind Research Network (MRN)
Harold Schultz, Ph.D., Department of Cellular & Integrative Physiology, UNMC
Julia Stephen, Ph.D., The Mind Research Network (MRN)
Yu-Ping Wang, Ph.D., Department of Biomedical Engineering, Tulane University

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Funding:

R01 MH103220-01A1, Wilson (PI)
08/01/2014 – 05/31/2019
NIH/NIMH
“Neurophysiological markers of HAND and the impact of aging: Evidence from MEG”
Role: Principal Investigator
This award uses MEG, functional MRI, structural MRI, and diffusion tensor imaging (DTI) to evaluate the neural mechanisms of HIV-associated neurocognitive disorders (HAND), which affect between 35-70% of all HIV-infected patients. A longitudinal component of the study will evaluate how HIV-infection differentially modulates the decline in cognitive and neural function that is associated with normal healthy aging.

R01 MH103220-02S1, Wilson (PI)
08/01/2015 – 05/31/2016
NIH/NIMH
Administrative Supplement: Sex differences in aging and the neurophysiological markers of HAND”
Role: Principal Investigator
This administrative supplement supports the recruitment of 60 additional women (30 HIV-infected and 30 healthy women), which pushes total enrollment in the parent project to approximately 250 participants. This increased sample size will enable adequately-powered statistical testing for sex differences in healthy aging, and the accelerated aging that is often associated with HIV-infection and HAND, among other conditions.

R01 MH103220-02S2, Wilson (PI)
08/01/2015 – 05/31/2019
NIH/NIMH
Administrative Supplement: Linking molecular markers of aging, the epigenome, and functional neuroimaging”
Role: Principal Investigator
This administrative supplement supports epigenetic analyses, including DNA methylation, on all participants (patients and controls) who were enrolled in the parent R01 and S1 projects. We will extract molecular markers of aging and assess how these metrics coalesce with indices of brain structure and function in healthy and HIV-infected participants ranging from 22 to 76 years-old. Other epigenetic analyses will also be conducted.

NSF #1539067, Calhoun, Stephen, Wang, & Wilson (Co-PIs)
08/01/2015 – 07/31/2019
National Science Foundation (NSF)
“Developmental Chronnecto-Genomics (Dev-CoG): A Next Generation Framework for Quantifying Brain Dynamics and Related Genetic Factors in Childhood”
Role: Co-Principal Investigator
This award supports a longitudinal study of structural and functional brain development in typically-developing 9-14 year-old participants, as well as a multi-institutional training program in computational and cognitive neuroscience. Genetic data, structural MRI, functional MRI, diffusion MRI, and MEG will be collected annually on about 225 youth at the University of Nebraska Medical Center (PI: Wilson) and the Mind Research Network in New Mexico (PI: Calhoun/Stephen). Multimodal imaging and genetic data will be processed using advanced network modeling approaches developed through the project, which are also a key aspect of the training mission.    

Shoemaker Prize for Neurodegenerative Research, Wilson (PI)
07/01/2015 – 06/30/2017
University of Nebraska Foundation
“Using noninvasive brain stimulation to normalize neural networks and reduce cognitive impairment in humans”
Role: Principal Investigator
With this award, we will investigate whether high-definition transcranial direct-current stimulation (HD-tDCS) of the dorsolateral prefrontal cortex significantly improves cognitive performance and normalizes brain function in critical networks of cognitively-impaired HIV-infected patients (i.e., those with HAND).

R01 HD086245-01, Kurz (PI)
09/01/2015 – 08/31/2019
NIH/NICHD
“Sensorimotor Learning in Children with Cerebral Palsy”
Role: Co-Investigator
This award uses MEG imaging and advanced neural oscillatory analyses to examine the mechanisms of motor learning in typically-developing children and those with cerebral palsy. All participants undergo repeated MEG recording sessions before and after specific motor training protocols.

A-START DA041917-01A1, Wilson (PI)
08/01/2016 – 07/30/2018
NIH/NIDA
“The impact of marijuana use on brain and cognitive function in HIV-infected patients”
Role: Principal Investigator
This AIDS-Science Track Award for Research Transition (A-START) will enable the PI to expand his research program into the area of drug abuse. The main project will utilize neuroimaging and neuropsychological testing to identify how HIV-associated neurocognitive disorders are affected by chronic marijuana use, and determine whether the severity of cognitive deficits is connected to the extent of marijuana consumption (heavy vs. light).

AHA Collaborative Sciences Award, Schultz & Wilson (Co-PIs)
07/01/2016 – 06/30/2019
American Heart Association
“Exploring the neurological basis of dyspnea and its impact on exercise intolerance in heart failure”
Role: Co-Principal Investigator
This translational study will identify the cortical brain circuits that underlie the sensation of dyspnea in humans with and without chronic heart failure (CHF) using MEG, and determine whether alterations in these circuits are linked to reduced exercise capacity in CHF. In parallel, dyspneic stimuli will be used to activate analogous brain circuits in rats with and without CHF, and we will test whether reversal of oxidative changes in dyspnea-related brain circuits improves autonomic and respiratory function, as well as exercise capacity in conscious CHF rats. 

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Techniques used in the laboratory

Magnetoencephalography (MEG)
Diffusion-weighted imaging (DTI)
Transcranial direct-current stimulation (tDCS)
Transcranial alternating-current stimulation (tACS)
Structural/functional magnetic resonance imaging (sMRI and fMRI)
Functional near-infrared spectroscopy (fNIRS)
Electroencephalography (EEG)
Intracranial recordings (electrocorticography, or ECoG)
Psychophysics/Behavioral Methods

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Personnel

Wilson Lab Members

Nathan Coolidge
Research Assistant

Nathan Coolidge

Christine Embury
Graduate Student

Christine Embury

Beth Heinrichs-Graham, Ph.D.
Instructor

Beth Heinrichs-Graham

Nichole Knott, R.EEG.T
MEG Specialist

nicoleknott

Timothy McDermott
Professional Research Assistant

Tim McDermott

Mackenzie Mills
Professional Research Assistant

Mackenzie Mills

Amy Proskovec
Graduate Student 

Amy Proskovec

Rachel Spooner
Graduate Student

Rachel Spooner

Alex Wiesman
Graduate Student

Alex Wiesman


Dr. Wilson's home page

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