Huangui Xiong, MD, PhD

Professor

Durham Research Center, Room 8013
985880 Nebraska Medical Center
Omaha, NE 68198-5880

Phone: 402-559-5140
Email

Keywords: synaptic transmission and plasticity, NMDA receptors, voltage-gated K channels, neuroinflammation, HIV-1-associated neurocognitive disorders

In the news
Research Interests
Professional Summary
Representative Publications
Dr. Xiong's biographical information
Visit Dr. Xiong's laboratory

In the news

Dr. Xiong describes his work.

Research Interests

Our laboratory studies cellular and molecular mechanisms underlying HIV-1-associated neurocognitive disorders (HAND), focusing on how virus and viral proteins  alter 1) neuronal physiology, synaptic transmission and plasticity via subtypes of NMDA receptors, and 2) mononuclear phagocytes (MPs, brain macrophages and microglia)-mediated neurotoxic activity via voltage-gated K channel Kv1.3.  How drug abuse, in particular methamphetamine, exacerbates HAND pathogenesis is another focus in our laboratory research.

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Professional Summary

The goals of our laboratory are:

• To elucidate molecular and cellular mechanisms underlying the pathogenesis of HIV-1-assciated neurocognitive disorder.
• To identify potential target(s) for development of therapeutic strategies.

Representative Publications

1. Zhang J, Boska M, Zheng Y, Liu J, Fox HS, Xiong H. Minocycline attenuation of rat corpus callosum abnormality mediated by low-dose lipopolysaccharide-induced microglia activation. J Neuroinflammation. 2021 Apr 26;18(1):100. PMID: 33902641; PMCID: PMC8077939.
2. Liu H, Yang XK, Yang J, Yuan YP, Wang YL, Zhang R, Xiong H, Xu YM. IL-17 inhibits oligodendrocyte progenitor cell proliferation and differentiation by increasing K+ channel Kv1.3.  Frontiers in Cellular Neuroscience. 2021, Jun 22;15:679413. doi: 10.3389/fncel.2021.679413. eCollection 2021. PMID: 34239419. PMCID: PMC8258110.
3. Zhang J, Gong X, Xiong H. Significant higher-level C-C motif chemokine ligand 2/3 and chemotactic power in cerebral white matter than grey matter in rat and human. Eur J Neurosci. 2021 Mar 16;. doi: 10.1111/ejn.15187. [Epub ahead of print] PubMed PMID: 33725384; NIHMSID:NIHMS1703713.
4. Zhang J, Fox H, Xiong H. Severer nodular lesion in white matter than in gray matter in simian immunodeficiency virus-infected monkey, but not closely correlated with viral infection. J Biomed Res. 2019 Aug 28;34(4):292-300. PubMed PMID: 32525497; PubMed Central PMCID: PMC7386408.
5. Zhang J, Yang X, Zhou Y, Fox H, Xiong H. Direct contacts of microglia on myelin sheath and Ranvier's node in the corpus callosum in rats. J Biomed Res. 2019 Jun 4;33(3):192-200. PubMed PMID: 30403198; PubMed Central PMCID: PMC6551421.
6. Xu E, Liu J, Liu H, Wang X, Xiong H. Inflammasome Activation by Methamphetamine Potentiates Lipopolysaccharide Stimulation of IL-1β Production in Microglia. J Neuroimmune Pharmacol. 2018 Jun;13(2):237-253. PubMed PMID: 29492824; PubMed Central PMCID: PMC6430126.
7. Liu J, Xu E, Tu G, Liu H, Luo J, Xiong H. Methamphetamine potentiates HIV-1gp120-induced microglial neurotoxic activity by enhancing microglial outward K⁺ Current. Mol Cell Neurosci. 2017 Jul;82:167-175.  PMID: 28552341. PMCID: PMC5524377.
8. Zhou Y, Liu J, Xiong H. HIV-1 Glycoprotein 120 Enhancement of N-Methyl-D-Aspartate NMDA Receptor-Mediated Excitatory Postsynaptic Currents: Implications for HIV-1-Associated Neural Injury. J Neuroimmune Pharmacol. 2017 Jun;12(2):314-326. PMID: 28005232. PMCID: PMC5944862.
9. Liu H, Liu J, Xu E, Tu G, Guo M, Liang S, Xiong H. Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K⁺current conducted by K_V3. Neurobiol Dis. 2017 Jan;97(Pt A):1-10. PMID: 27816768.  PMCID: PMC5138138.
10. Zhou Y, Tang H, Xiong H. Chemokine CCL2 enhances NMDA receptor-mediated excitatory postsynaptic current in rat hippocampal slices-a potential mechanism for HIV-1-associated neuropathy? J Neuroimmune Pharmacol. 2016 Jun;11(2):306-15. PMID: 26968849. PMCID: PMC5051695.