Professor

Durham Research Center, Room 8013
985880 Nebraska Medical Center
Omaha, NE 68198-5880

Phone: 402-559-5140
Email

Keywords: synaptic transmission and plasticity, NMDA receptors, learning and memory;  neuroinflammation, voltage-gated K channels,  HIV-1-associated neurocognitive disorders

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Research Interests
Professional Summary
Representative Publications
Dr. Xiong's biographical information
Visit Dr. Xiong's laboratory

In the news

Dr. Xiong describes his work.

Research Interests

The research in our laboratory studies cellular and molecular mechanisms underlying HIV-1-associated neurocognitive disorders (HAND).  Specifically, we are interested in how virus and viral proteins impact 1) neuronal physiology, synaptic transmission and plasticity via subtypes of NMDA receptors, and 2) mononuclear phagocytes (MPs, brain macrophages and microglia)-mediated neurotoxic activity via voltage-gated K channel Kv1.3.

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Professional Summary

The goals of our laboratory are:

• To investigate the involvement of extra-synaptic NR2B receptors in HAND pathogenesis and evaluate therapeutic potential of specific NR2B antagonists.
• To determine and characterize voltage-gated K channel Kv1.3 in neurotoxic activity induced by HIV- and/or viral protein-activated MPs and explore effects of  Kv channel blockers in attenuation/prevention of MP-associated neurotoxicity. 

Representative Publications

1. Liu J, Xu E, Tu G, Liu H, Luo J, Xiong H. Methamphetamine potentiates HIV-1gp120-induced microglial neurotoxic activity by enhancing microglial outward K⁺ current. Mol Cell Neurosci. 2017 Jul;82:167-175. PMID: 28552341
2. Zhou Y, Liu J, Xiong H. HIV-1 Glycoprotein 120 Enhancement of N-Methyl-D-Aspartate NMDA Receptor-Mediated Excitatory Postsynaptic Currents: Implications for HIV-1-Associated Neural Injury. J Neuroimmune Pharmacol. 2017 Jun;12(2):314-326. PMID: 28005232.
3. Liu H, Liu J, Xu E, Tu G, Guo M, Liang S, Xiong H. Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K⁺current conducted by K_V1.3. Neurobiol Dis. 2017 Jan;97(Pt A):1-10. Neurobiol Dis. 2017 Jan;97(Pt A):1-10. PMID: 27816768. 
4. López SN, Rodríguez-Valentín M, Rivera M, Rodríguez M, Babu M, Cubano LA, Xiong H, Wang G, Kucheryavykh L, Boukli NM. HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma. Oncotarget. 2017 Jul 22;8(40):68415-68438. PMID: 28978127 
5. Wang Y, Li Y, Zhao R, Wu B, Lanoha B, Tong Z, Peer J, Liu J, Xiong H, Huang Y, Zheng J. Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice. Brain Behav Immun. 2017 Nov;66:135-145. PMID: 28624534
6. Cai Y, Yang L, Hu G, Chen X, Niu F, Yuan L, Liu H, Xiong H, Arikkath J, Buch S. Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy. J Cell Biol. 2016 Oct 24;215(2):245-258. 
7. Zhao J, Liu J, Xu E, Liu Y, Xie A, Xiong H. dl-3-n-Butylphthalide attenuation of methamphetamine-induced neurotoxicity in SH-SY5Y neuroblastoma cells. Life Sci. 2016 Nov 15;165:16-20. PMID: 27640886.
8. Liu H, Xu E, Liu J, Xiong H. Oligodendrocyte Injury and Pathogenesis of HIV-1-Associated Neurocognitive Disorders. Brain Sci. 2016 Jul 22;6(3). PMID: 27455335
9. Zhou Y, Tang H, Xiong H. Chemokine CCL2 enhances NMDA receptor-mediated excitatory postsynaptic current in rat hippocampal slices-a potential mechanism for HIV-1-associated neuropathy? J Neuroimmune Pharmacol. 2016 Jun;11(2):306-15. PMID: 26968849
10. Reiner B, Wang W, Liu J, Xiong H. Platelet-activating factor attenuation of long-term potentiation in rat hippocampal slices via protein tyrosine kinase signaling. Neurosci Lett. 2016 Feb 26;615:83-7. PMID: 26808643
11. Kiyota T, Morrison CM, Tu G, Dyavarshetty B, Weir RA, Zhang G, Xiong H, Gendelman HE. Presenilin-1 familial Alzheimer's disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice. Brain Behav Immun. 2015 Oct;49:311-21. PMID: 26112421
12. Liu H, Liu J, Liang S, Xiong H. (2013) Plasma gelsolin protects HIV-1 gp120-Induced neuronal injury via voltage-gated K+ channel Kv2.1. Mol Cell Neurosci S1044-7431(13): 00101-2. PMID: 24513395
13. Liu J, Xu P, Collins C, Liu H, Zhang J, Keblesh JP, Xiong H. (2013) HIV-1 Tat protein increases microglial outward K(+) current and resultant neurotoxic activity. PLoS One 8(5): e64904. PMID: 23738010
14. Yang J, Hu D, Xia J, Liu J, Zhang G, Gendelman HE, Boukli NM, Xiong H. (2013) Enhancement of NMDA receptor-mediated excitatory postsynaptic currents by gp120-treated macrophages: implications for HIV-1-associated neuropathology. J Neuroimmune Pharmacol 8(4): 921-33. PMID: 23660833
15. Zhang J, Liu J, Fox HS, Xiong H. (2013) N-methyl-D-aspartate receptor-mediated axonal injury in adult rat corpus callosum. J Neurosci Res 91(2): 240-8. PMID: 23161705