Durham Research Center, 3014
985800 Nebraska Medical Center
Omaha, NE 68198-5800
Keywords: microRNAs in neurodegenerative diseases, HIV, Parkinson's Disease
Positions Available !
Postdoctoral research positions
Positions are currently open for postdoctoral fellows. Visit the Opportunities page for available positions. Students interested in graduate studies should apply to the Office of Graduate Studies. For additional information contact Dr. Sowmya Yelamanchili, Ph.D.
Grant will fund study of meth neurotoxicity
UNMC Today | December 27, 2016
The overarching goal of my independent research program is to understand the role of regulatory molecules such as genes, proteins and microRNAs in the pathogenesis of neurological disorders and in the field of drug addiction, specifically methamphetamine (Meth) abuse.
Meth and related amphetamine compounds, which are potent psychostimulants, are among the most commonly used illicit drugs. With > 35 million users worldwide, Meth abuse poses a significant health and economic threat globally. Acute and chronic doses of Meth have been shown to produce long-term damage in many brain regions. However, the mechanisms underlying Meth neurotoxicity are still not known. An important and emerging player is extracellular vesicles (EVs) and their role in chronic Meth abuse.
Extracellular vesicles (EVs) have been garnering increasing interest for their role in several neurological disorders and understanding their role in the brain during drug abuse is just beginning to emerge. EVs can release their cargo into target cells and trigger downstream signaling pathways. Our studies have revealed that EV associated microRNA (miRNA) cargo can be responsible for neuronal injury. However, EV miRNA cargo and their involvement in Meth associated neurotoxicity is not well understood thus warranting further studies in this direction. We are particularly interested in understanding the effect of such EV-carried miRNAs on neurons. We have successfully shown to use various model systems including human biospecimens, rhesus macaques in addition to rodent models and in vitro work to study the pathogenesis in the brain.
Present work in my laboratory focuses on investigating the role of extracellular vesicles and their microRNA cargo in chronic methamphetamine abuse and during HIV infection.
- Hu G, Yelamanchili S, Kashanchi F, Haughey N, Bond VC, Witwer KW, Pulliam L, Buch S. Proceedings of the 2017 ISEV symposium on "HIV, NeuroHIV, drug abuse, & EVs". J Neurovirol. 2017 Dec;23(6):935-940. PMID: 29147885
- Harrison EB, Emanuel K, Lamberty BG, Morsey BM, Li M, Kelso ML, Yelamanchili SV, Fox HS. Induction of miR-155 after Brain Injury Promotes Type 1 Interferon and has a Neuroprotective Effect. Front Mol Neurosci. 2017 Jul 28;10:228. PMID: 28804446
- Harrison EB, Hochfelder CG, Lamberty BG, Meays BM, Morsey BM, Kelso ML, Fox HS, Yelamanchili SV. Traumatic brain injury increases levels of miR-21 in extracellular vesicles: implications for neuroinflammation. FEBS Open Bio. 2016 Jun 14;6(8):835-46. doi: 10.1002/2211-5463.12092. PubMed PMID: 27516962; PubMed Central PMCID: PMC4971839.
- Yelamanchili SV, Lamberty BG, Rennard DA, Morsey BM, Hochfelder CG, Meays BM, Levy E, Fox HS. MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease. PLoS Pathog. 2015 Jul 8;11(7):e1005032. doi: 10.1371/journal.ppat.1005032. Erratum in: PLoS Pathog. 2015 Sep;11(9):e1005131. PubMed PMID: 26154133; PubMed Central PMCID: PMC4496044.
- Basma H, Gunji Y, Iwasawa S, Nelson A, Farid M, Ikari J, Liu X, Wang X, Michalski J, Smith L, Iqbal J, El Behery R, West W, Yelamanchili S, Rennard D, Holz O, Mueller KC, Magnussen H, Rabe K, Castaldi PJ, Rennard SI. Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306(6):L552-65. doi: 10.1152/ajplung.00255.2013. PubMed PMID: 24487392; PubMed Central PMCID: PMC3949084.
- Yelamanchili SV, Morsey B, Harrison EB, Rennard DA, Emanuel K, Thapa I, Bastola DR, Fox HS. The evolutionary young miR-1290 favors mitotic exit and differentiation of human neural progenitors through altering the cell cycle proteins. Cell Death Dis. 2014 Jan 9;5:e982. doi: 10.1038/cddis.2013.498. PubMed PMID: 24407235; PubMed Central PMCID: PMC4040694
- Chaudhuri AD, Yelamanchili SV, Marcondes MC and Fox HS (2013). Upregulation of MicroRNA-142 in Simian Immunodeficiency Virus Encephalitis leads to Repression of Sirtuin1.FASEB J. 2013 Jun 10. PMID 23752207
- Chaudhuri AD, Yelamanchili SV and Fox HS (2013). Combined Fluorescent in situ Hybridization for detection of microRNAs and Immunofluorescent Labeling for Cell-Type Markers. Frontiers in Cell. Neurosci. Sep 23;7:160 PMID 24065888
- Chaudhuri AD, Yelamanchili SV and Fox HS (2013). MicroRNA-142 Reduces Monoamine Oxidase A Expression and Activity in Neuronal Cells by Downregulating SIRT1. Plos One, 8(11):e79579. PMID 24244526
- Hu G, Yao H, Chaudhuri AD, Duan M, Yelamanchili SV, Wen H, Cheney PD, Fox HS, Buch S (2012). Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction. Cell Death and Disease. Aug 30; 3:e381. PMID 22932723
- Yelamanchili SV, Chaudhuri AD A, Flynn C, Fox HS (2011). Upregulation of Cathepsin D in the caudate nucleus of primates with experimental parkinsonism. Molecular Neurodegeneration, Jul 21; 6:52 PMID 21777416
- Yelamanchili SV, Datta-Chaudhari A, Chen L, Xiong H and Fox HS. MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease. Cell Death Dis., 2010, 1 (9) e77. PMID 21170291
- Yelamanchili SV and Fox HS. Defining Larger Roles for "Tiny" RNA Molecules: Role of miRNAs in Neurodegeneration Research. J. Neuroimmune Pharmacol., 2010, 5:63-69. PMID 19757077
- Darna M, Schmutz I, Richter K, Yelamanchili SV, Pendyala G, Holtje M, Albrecht U, Ahnert-Hilger G. (2009) Time-of-day dependent sorting of vesicular glutamate transporter to the plasma membrane. J Biol Chem, 284(7):4300-07
- Darna M, Schmutz I, Richter K, Yelamanchili SV, Pendyala G, Holtje M, Albrecht U, Ahnert-Hilger G (2009). Time-of-day dependent sorting of vesicular glutamate transporter to the plasma membrane. J Biological Chemistry 284(7): 4300-7
- Yelamanchili SV, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert-Hilger G (2006) “Differential sorting of the Vesicular Glutamate Transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2”, Journal of Biological Chemistry 281, 15671-15679