2012 CHAIN Colloquium

Biomarkers for NeuroAIDS - Recent Progress in the Field

Biomarkers for NeuroAIDS

June 5, 2012

As we enter the 4th decade of the HIV pandemic, investigations into the diagnosis, prevention, and treatment of the virus’s effects on the nervous system continue to evolve.

Despite substantive positive outcomes seen in disease morbidity and mortality as a consequence of combination antiretroviral therapy, viral infection continues to affect the nervous system as HIV-associated neurocognitive disorders (HAND, or neuroAIDS).

One critical gap in neuroAIDS research, similar to many other neuropsychiatric and neurodegenerative conditions, is the identification of reliable molecular biomarkers.

The day’s talks and discussion will highlight the work of the NIMH neuroAIDS centers as well as that of other outstanding researchers in the field performing state-of-the-art research into the identification of clinically relevant biomarkers to aid in improving current diagnosis, developing new presymptomatic treatments and identifying high-risk individuals and disease subgroups.

Download the day's program for speakers bios.

Welcome
Howard S. Fox, M.D., Ph.D., University of Nebraska Medical Center

Cristian L. Achim M.D., PhD, University of California, San Diego
"Studies of micro RNA and findings in the brain as potential biomarkers of HAND"

Beau M. Ances, M.D., Ph.D., Washington University, St. Louis
"Neuroimaging Biomarkers of HAND - Are We There Yet?"

Joan W. Berman, Ph.D., Albert Einstein College of Medicine
"Prion protein as a biomarker: Clues in  the pathogenesis of  HAND"

Pawel Ciborowski, Ph.D., University of Nebraska Medical Center
HAND, biomarkers and proteomics:  What’s next?

Howard S. Fox, M.D., Ph.D., University of Nebraska Medical Center
Proteomic studies for biomarkers in HAND"

Howard E. Gendelman, M.D., University of Nebraska Medical Center
Biomarkers for nanomedicine”

Igor Grant, M.D., F.R.C.P.(C), University of California, San Diego
"Current status of HAND and Perspectives on Biomarkers"

Norman Haughey, Ph.D., The Johns Hopkins School of Medicine
"Lipidomic/metabolomic studies for biomarkers in HAND"

Justin C. McArthur, M.B.B.S., M.PH., F.A.A.N., The Johns Hopkins School of Medicine
"Development of Biomarkers: Progress and Pitfalls"

Avindra Nath, M.D., National Institutes of Health
"Biomarker studies on oxidative stress in HAND"

Richard Price, M.D., University of California, San Francisco
"Strategies for CSF Biomarker Discovery and Evaluation in HIV Infection"

Ronald Ellis, M.D., Ph.D., University of California, San Diego
"Biomarkers in the current era of HAND"

Panel Discussion - All presenters
Moderator:  Shilpa Buch, Ph.D., University of Nebraska Medical Center

Sponsored by:

Chronic HIV infection and Aging in NeuroAIDS (CHAIN) Center - PI, Howard Fox

University of Nebraska Medical Center Development Funds - PI, Shilpa Buch

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Howard E. Gendelman, MD, Chair

A special thank you to the National Institute of Mental Health for its support of the CHAIN Center.