NanoART publications

Publications resulting from NanoART Manufacture, Delivery and Pharmacokinetics for Optimizing Drug Adherence

2020   2015
2019   2014
2018   2013
2017   2012
2016   2011
    2010
Books and book chapters

2020

Banoub MG, Bade AN, Lin Z, Cobb D, Gautam N, Dyavar Shetty BL, Wojtkiewicz M, Alnouti Y, McMillan J, Gendelman HE, Edagwa B (2020) Synthesis and Characterization of Long-Acting Darunavir Prodrugs. Mol Pharm 17:155-166. PubMed PMID: 31742407

Dash PK, Kevadiya BD, Su H, Banoub MG, Gendelman HE. Pathways towards human immunodeficiency virus elimination. EBioMedicine 2020; 53:102667. 10.1016/j.ebiom.2020.102667. PubMed PMID 32114397; PMC7047153

Gautam N, Alamoudi JA, Kumar S, Alnouti Y. Direct and indirect quantification of phosphate metabolites of nucleoside analogs in biological samples. J Pharm Biomed Anal. 2020; 178:112902. 10.1016/j.jpba.2019.112902. PMID 31610397; PMC6931899.

Kulkarni TA, Bade AN, Sillman B, Shetty B, Wojtkiewicz MS, Gautam N, Hilaire JR, Sravanam S, Szlachetka A, Lamberty BG, Morsey BM, Fox HS, Alnouti Y, McMillan JM, Mosley R, Meza J, Domanico PL, Yue T, Moore G, Edagwa BJ, Gendelman HE. A Year-Long Extended Release Nanoformulated Cabotegravir Prodrug. Nature Materials. 2020; doi: 10.1038/s41563-020-0674-z. PubMed PMID: 32341511.

Kevadiya BD, Ottemann B, Mukadam IZ, Castellanos L, Sikora K, Hilaire JR, Machhi J, Herskovitz J, Soni D, Hasan M, Zhang W, Anandakumar S, Garrison J, McMillan J, Edagwa B, Mosley RL, Vachet RW, Gendelman HE (2020) Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues. Theranostics 10:630-656. doi: 10.7150/thno.39847. PubMed: PMID: 31903142. PMCID: PMC6929995.

2019

Dash PK, Kaminski R, Bella R, Su H, Mathews S, Ahooyi TM, Chen C, Mancuso P, Sariyer R, Ferrante P, Donadoni M, Robinson JA, Sillman B, Lin Z, Hilaire JR, Banoub M, Elango M, Gautam N, Mosley RL, Poluektova LY, McMillan J, Bade AN, Gorantla S, Sariyer IK, Burdo TH, Young WB, Amini S, Gordon J, Jacobson JM, Edagwa B, Khalili K, Gendelman HE. Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice. Nat Commun. 2019 Jul 2;10(1):2753. PMID: 31266936

Domingo-Almenara X, Montenegro-Burke JR, Guijas C, Majumder EL, Benton HP, Siuzdak G. 2019. Autonomous METLIN-Guided In-source Fragment Annotation for Untargeted Metabolomics. Anal Chem 91:3246-3253. PMID: 30681830. PMCID: PMC6637741

Gendelman HE, Taylor R (2019) In Appreciation for a Job Well Done! J Neuroimmune Pharmacol 14:1. PMC6412015

Gendelman HE, McMillan J, Bade AN, Edagwa B, Kevadiya BD (2019) The Promise of Long-Acting Antiretroviral Therapies: From Need to Manufacture. Trends Microbiol 27:593-606. PMID: 30981593. PMC6571075

Herskovitz J, Gendelman HE (2019) HIV and the Macrophage: From Cell Reservoirs to Drug Delivery to Viral Eradication. J Neuroimmune Pharmacol 14:52-67. PMID: 29572681. PMC6501843

Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. Creation of a long-acting rilpivirine prodrug nanoformulation. J Control Release 2019; 311-312:201-11. doi: 10.1016/j.jconrel.2019.09.001. PubMed PMID: 31491432. PMCID: PMC6875695.

Ibrahim IM, Bade AN, Lin Z, Soni D, Wojtkiewicz M, Dyavar Shetty BL, Gautam N, McMillan JM, Alnouti Y, Edagwa BJ, Gendelman HE. Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation. Int J Nanomedicine 2019; 14:6231-47. doi: 10.2147/IJN.S215447. PubMed PMID: 31496683; PMCID: PMC6689761

Keshavjee, S., F. Amanullah, A. Cattamanchi, R. Chaisson, K. M. Dobos, G. J. Fox, H. E. Gendelman, R. Gordon, A. Hesseling, H. Le Van, B. Kampmann, B. Kana, G. Khuller, D. M. Lewinsohn, D. A. Lewinsohn, P. L. Lin, L. L. Lu, G. Maartens, A. Owen, M. Protopopova, J. Rengarajan, E. Rubin, P. Salgame, E. Schurr, J. A. Seddon, S. Swindells, D. M. Tobin, Z. Udwadia, G. Walzl, S. Srinivasan, R. Rustomjee and P. Nahid (2019). Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection. Am J Respir Crit Care Med 199:564-571. PMID: 30335466. PMC6396859

Mathews S, Branch Woods A, Katano I, Makarov E, Thomas MB, Gendelman HE, Poluektova LY, Ito M, Gorantla S (2019) Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice. Mol Neurodegener 14:12. PMID: 30832693. PMC6399898.

McMillan J, Szlachetka A, Zhou T, Morsey B, Lamberty B, Callen S, Gautam N, Alnouti Y, Edagwa B, Gendelman HE, Fox HS. 2019. Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques. Aids 33:585-588. PMID: 30289818

Montenegro-Burke JR, Woldstad CJ, Fang M, Bade AN, McMillan J, Edagwa B, Boska MD, Gendelman HE, Siuzdak G. 2019. Nanoformulated Antiretroviral Therapy Attenuates Brain Metabolic Oxidative Stress. Mol Neurobiol 56:2896-2907. PMID: 30069830

Mosley RL, Lu Y, Olson KE, Machhi J, Yan W, Namminga KL, Smith JR, Shandler SJ, Gendelman HE (2019) A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson's Disease. Front Cell Neurosci 13:421. 2019/10/18. 10.3389/fncel.2019.00421. PMID: 31619964; PMC6759633.

Mukadam IZ, Machhi J, Herskovitz J, Hasan M, Oleynikov MD, Blomberg WR, Svechkarev D, Mohs AM, Zhou Y, Dash P, McMillan J, Gorantla S, Garrison J, Gendelman HE, Kevadiya BD (2020) Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking. Biomaterials 231:119669. 2019/12/23. 10.1016/j.biomaterials.2019.119669. PMID 31865227.

Rinschen MM, Ivanisevic J, Giera M, Siuzdak G (2019) Identification of bioactive metabolites using activity metabolomics. Nat Rev Mol Cell Biol 20:353-367. PMID: 30814649. PMC6613555

Saminathan P, Kevadiya BD, Marker DF, Gendelman HE, Gorantla S, Gelbard HA. 2019. Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages. J Neuroimmune Pharmacol 14:44-51. PMID: 30617749. PMCID: PMC6391203

Smith N, Bade AN, Soni D, Gautam N, Alnouti Y, Herskovitz J, Ibrahim IM, Wojtkiewicz MS, Dyavar Shetty BL, McMillan J,  Gendelman HE, Edagwa B. A long acting nanoformulated lamivudine ProTide. Biomaterials 2019; 223:119476. doi: 10.1016/j.biomaterials. 2019.119476. PubMed PMID: 31525692. PMCID: PMC6945491.

Soni, D., Bade, A. N., Gautam, N., Herskovitz, J., Ibrahim, I. M., Smith, N., Wojtkiewicz, M. S., Dyavar Shetty, B. L., Alnouti, Y., McMillan, J., Gendelman, H. E. Edagwa, B. J. Synthesis of a long acting nanoformulated emtricitabine ProTide. Biomaterials 222, 119441, doi:10.1016/j.biomaterials. 2019.119441. PubMed PMID: 31472458. PMCID: PMCID: PMC6945494 

Su H, Cheng Y, Sravanam S, Mathews S, Gorantla S, Poluektova LY, Dash PK, Gendelman HE. 2019. Immune Activations and Viral Tissue Compartmentalization During Progressive HIV-1 Infection of Humanized Mice. Front Immunol 10:340. PMID: 30873181. PMCID: PMC6403174.

Tomitaka A, Kaushik A, Kevadiya BD, Mukadam I, Gendelman HE, Khalili K, Liu G, Nair M. Surface-engineered multimodal magnetic nanoparticles to manage CNS diseases. Drug Discov Today 2019; 24:873-82. doi: 10.1016/j.drudis.2019.01.006. PMID: 30660756

2018

Beyer BA, Fang M, Sadrian B, Montenegro-Burke JR, Plaisted WC, Kok BPC,Saez E, Kondo T, Siuzdak G, Lairson LL. Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation. Nature chemical biology. 2018;14(1):22-8. Epub 2017/11/14. doi: 10.1038/nchembio.2517. PubMed PMID: 29131145. PMCID: PMC5928791

Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD. Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. J Biomed Mater Res A. 2018;106(11):2881-90. Epub 2018/10/29. doi: 10.1002/jbm.a.36477. PubMed PMID: 30369055; PMCID: PMC6366942.

Domingo-Almenara X, Montenegro-Burke JR, Ivanisevic J, Thomas A, Sidibe J, Teav T, Guijas C, Aisporna AE, Rinehart D, Hoang L, Nordstrom A, Gomez-Romero M, Whiley L, Lewis MR, Nicholson JK, Benton HP, Siuzdak G. XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules. Nat Methods. 2018;15(9):681-4. Epub 2018/08/29. doi: 10.1038/s41592-018-0110-3. PubMed PMID: 30150755; PMCID: PMC6629029.

Edagwa BJ, Gendelman HE. Antimicrobials: Broad-spectrum antivirals. Nat Mater. 2018;17(2):114-6. Epub 2018/01/24. doi: 10.1038/nmat5064. PubMed PMID: 29358769.

Forsberg EM, Huan T, Rinehart D, Benton HP, Warth B, Hilmers B, Siuzdak G. Data processing, multi-omic pathway mapping, and metabolite activity analysis using XCMS Online. Nature protocols. 2018;13(4):633-51. Epub 2018/03/02. doi: 10.1038/nprot.2017.151. PubMed PMID: 29494574. PMCID: PMC5937130

Gautam N, Lin Z, Banoub MG, Smith NA, Maayah A, McMillan J, Gendelman HE, Alnouti Y. Simultaneous quantification of intracellular lamivudine and abacavir triphosphate metabolites by LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2018;153:248-59. Epub 2018/03/09. doi: 10.1016/j.jpba.2018.02.036. PubMed PMID: 29518644; PubMed Central PMC5860827.

Gu CJ, Borjabad A, Hadas E, Kelschenbach J, Kim BH, Chao W, Arancio O, Suh J, Polsky B, McMillan J, Edagwa B, Gendelman HE, Potash MJ, Volsky DJ. EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. PLoS Pathog. 2018;14(6):e1007061. Epub 2018/06/08. doi: 10.1371/journal.ppat.1007061. PubMed PMID: 29879225; PMCID: PMC5991655.

Guijas C, Montenegro-Burke JR, Warth B, Spilker ME, Siuzdak G. Metabolomics activity screening for identifying metabolites that modulate phenotype. Nature biotechnology. 2018;36(4):316-20. Epub 2018/04/06. doi: 10.1038/nbt.4101. PubMed PMID: 29621222. PMCID: PMC5937131.

Herskovitz J, Gendelman HE. HIV and the Macrophage: From Cell Reservoirs to Drug Delivery to Viral Eradication. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2018. Epub 2018/03/25. doi: 10.1007/s11481-018-9785-6. PubMed PMID: 29572681.

Kevadiya BD, Ottemann BM, Thomas MB, Mukadam I, Nigam S, McMillan J, Gorantla S, Bronich TK, Edagwa B, Gendelman HE. Neurotheranostics as personalized medicines. Adv Drug Deliv Rev. 2018. Epub 2018/11/14. doi: 10.1016/j.addr.2018.10.011. PubMed PMID: 30421721; PMCID: PMC6486471.

Kevadiya BD, Woldstad C, Ottemann BM, Dash P, Sajja BR, Lamberty B, Morsey B, Kocher T, Dutta R, Bade AN, Liu Y, Callen SE, Fox HS, Byrareddy SN, McMillan JM, Bronich TK, Edagwa BJ, Boska MD, Gendelman HE. Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution. Theranostics. 2018;8(1):256-76. Epub 2018/01/02. doi: 10.7150/thno.22764. PubMed PMID: 29290806; PubMed Central PMC5743473.

Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Yokoyama I, Lee Mosley R, Gendelman HE. Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice. Journal of neuroimmunology. 2018;319:80-92. Epub 2018/03/27. doi: 10.1016/j.jneuroim.2018.03.009. PubMed PMID: 29573847; PubMed Central PMC5916331.

Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Zhang G, Mosley RL, Gelbard HA, Gendelman HE. URMC-099 facilitates amyloid-beta clearance in a murine model of Alzheimer's disease. J Neuroinflammation. 2018;15(1):137. Epub 2018/05/08. doi: 10.1186/s12974-018-1172-y. PMID: 29729668

Lin Z, Gautam N, Alnouti Y, McMillan J, Bade AN, Gendelman HE, Edagwa B. ProTide generated long-acting abacavir nanoformulations. Chem Commun (Camb). 2018;54(60):8371-4. Epub 2018/07/12. doi: 10.1039/c8cc04708a. PubMed PMID: 29995046; PMCID: PMC6063073

McMillan JM, Cobb DA, Lin Z, Banoub MG, Dagur RS, Branch Woods AA, Wang W, Makarov E, Kocher T, Joshi PS, Quadros RM, Harms DW, Cohen SM, Gendelman HE, Gurumurthy CB, Gorantla S, Poluektova LY. Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice. The Journal of pharmacology and experimental therapeutics. 2018;365(2):272-80. Epub 2018/02/25. doi: 10.1124/jpet.117.247288. PubMed PMID: 29476044; PubMed Central PMC5878674.

McMillan J, Szlachetka A, Slack L, Sillman B, Lamberty B, Morsey B, Callen S, Gautam N, Alnouti Y, Edagwa B, Gendelman HE, Fox HS. Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques. Antimicrobial agents and chemotherapy. 2018;62(1). Epub 2017/10/25. doi: 10.1128/aac.01316-17. PubMed PMID: 29061742; PubMed Central PMC5740312.

Olson KE, Bade AN, Namminga KL, Potash MJ, Mosley RL, Poluektova LY, Volsky DJ, Gendelman HE. Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice. Journal of neurovirology. 2018. Epub 2018/03/30. doi: 10.1007/s13365-018-0629-1. PubMed PMID: 29594983.

Ottemann BM, Helmink AJ, Zhang W, Mukadam I, Woldstad C, Hilaire JR, Liu Y, McMillan JM, Edagwa BJ, Mosley RL, Garrison JC, Kevadiya BD, Gendelman HE. Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities. Biomaterials. 2018;185:174-93. Epub 2018/09/25. doi: 10.1016/j.biomaterials.2018.09.018. PubMed PMID: 30245386; PMCID: PMC6556898

Sarwar HS, Sohail MF, Saljoughian N, Rehman AU, Akhtar S, Nadhman A, Yasinzai M, Gendelman HE, Satoskar AR, Shahnaz G. Design of mannosylated oral amphotericin B nanoformulation: efficacy and safety in visceral leishmaniasis. Artif Cells Nanomed Biotechnol. 2018;46(sup1):521-31. Epub 2018/02/02. doi: 10.1080/21691401.2018.1430699. PubMed PMID: 29385910.

Schutt CR, Gendelman HE, Mosley RL. Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson's disease. Mol Neurodegener. 2018;13(1):26. Epub 2018/05/23. doi: 10.1186/s13024-018-0255-7. PubMed PMID:29783988; PMCID: PMC5963189.

Sillman B, Bade AN, Dash PK, Bhargavan B, Kocher T, Mathews S, Su H, Kanmogne GD, Poluektova LY, Gorantla S, McMillan J, Gautam N, Alnouti Y, Edagwa B, Gendelman HE. Creation of a long-acting nanoformulated dolutegravir. Nature communications. 2018;9(1):443. Epub 2018/02/07. doi: 10.1038/s41467-018-02885-x. PubMed PMID: 29402886; PubMed Central PMC5799307.

Sillman B, Woldstad C, McMillan J, Gendelman HE. Neuropathogenesis of human immunodeficiency virus infection. Handb Clin Neurol. 2018;152:21-40. Epub 2018/04/02. doi: 10.1016/b978-0-444-63849-6.00003-7. PubMed PMID: 29604978.

Thomas MB, Gnanadhas DP, Dash PK, Machhi J, Lin Z, McMillan J, Edagwa B, Gelbard H, Gendelman HE, Gorantla S. Modulating cellular autophagy for controlled antiretroviral drug release. Nanomedicine (Lond). 2018;13(17):2139-54. Epub 2018/08/22. doi: 10.2217/nnm-2018-0224. PubMed PMID: 30129397; PMCID: PMC6219451

Zhou T, Lin Z, Puligujja P, Palandri D, Hilaire J, Arainga M, Smith N, Gautam N, McMillan J, Alnouti Y, Liu X, Edagwa B, Gendelman HE. Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals. Nanomedicine (London, England). 2018. Epub 2018/03/20. doi: 10.2217/nnm-2017-0381. PubMed PMID: 29553879.

Zhou T, Su H, Dash P, Lin Z, Dyavar Shetty BL, Kocher T, Szlachetka A, Lamberty B, Fox HS, Poluektova L, Gorantla S, McMillan J, Gautam N, Mosley RL, Alnouti Y, Edagwa B, Gendelman HE. Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials. 2018;151:53-65. Epub 2017/10/24. doi: 10.1016/j.biomaterials.2017.10.023. PubMed PMID: 29059541; PubMed Central PMC5926202.

2017

Arainga M, Edagwa B, Mosley RL, Poluektova LY, Gorantla S, Gendelman HE. A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy. Retrovirology. 2017;14(1):17. Epub 2017/03/11. doi: 10.1186/s12977-017-0344-7. PubMed PMID: 28279181; PubMed Central PMC5345240.

Bade AN, Gendelman HE, Boska MD, Liu Y. MEMRI is a biomarker defining nicotine-specific neuronal responses in subregions of the rodent brain. American journal of translational research. 2017;9(2):601-10. Epub 2017/03/25. PubMed PMID: 28337287; PubMed Central PMC5340694.

Edagwa B, McMillan J, Sillman B, Gendelman HE. Long-acting slow effective release antiretroviral therapy. Expert opinion on drug delivery. 2017;14(11):1281-91. Epub 2017/01/28. doi: 10.1080/17425247.2017.1288212. PubMed PMID: 28128004; PubMed Central PMC5545165.

Embury CM, Dyavarshetty B, Lu Y, Wiederin JL, Ciborowski P, Gendelman HE, Kiyota T. Cathepsin B Improves ss-Amyloidosis and Learning and Memory in Models of Alzheimer's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2017;12(2):340-52. Epub 2016/12/15. doi: 10.1007/s11481-016-9721-6. PubMed PMID: 27966067; PubMed Central PMC5405105.

Gendelman HE. Thank You! Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2017;12(4):565. Epub 2017/11/11. doi: 10.1007/s11481-017-9769-y. PubMed PMID: 29124657; PubMed Central PMC5776721.

Gnanadhas DP, Dash PK, Sillman B, Bade AN, Lin Z, Palandri DL,Gautam N, Alnouti Y, Gelbard HA, McMillan J, Mosley RL, Edagwa B, Gendelman HE, Gorantla S. Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs. The Journal of clinical investigation. 2017;127(3):857-73. Epub 2017/01/31. doi: 10.1172/jci90025. PubMed PMID: 28134625; PubMed Central PMC5330738.

Guo D, Zhou T, Arainga M, Palandri D, Gautam N, Bronich T, Gautam N, Alnouti Y, Gelbard HA, McMillan J, Mosley RL, Edagwa B, Gendelman HE, Gorantla S. Creation of a Long-Acting Nanoformulated 2',3'-Dideoxy-3'-Thiacytidine. Journal of acquired immune deficiency syndromes (1999). 2017;74(3):e75-e83. Epub 2016/10/19. doi: 10.1097/qai.0000000000001170. PubMed PMID: 27559685; PubMed Central PMC5305294.

Heinrichs-Graham E, Santamaria PM, Gendelman HE, Wilson TW. The cortical signature of symptom laterality in Parkinson's disease. NeuroImage Clinical. 2017;14:433-40. Epub 2017/03/09. doi: 10.1016/j.nicl.2017.02.010. PubMed PMID: 28271041; PubMed Central PMC5322212.

Huan T, Forsberg EM, Rinehart D, Johnson CH, Ivanisevic J, Benton HP, Fang M, Aisporna A, Hilmers B, Poole FL, Thorgersen MP, Adams MWW, Krantz G, Fields MW, Robbins PD, Niedernhofer LJ, Ideker T, Majumder EL, Wall JD, Rattray NJW, Goodacre R, Lairson LL, Siuzdak G. Systems biology guided by XCMS Online metabolomics. Nature methods. 2017;14(5):461-2. Epub 2017/04/28. doi: 10.1038/nmeth.4260. PubMed PMID: 28448069.

Kevadiya BD, Bade AN, Woldstad C, Edagwa BJ, McMillan JM, Sajja BR, Boska MD, Gendelman HE. Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging. Acta biomaterialia. 2017;49:507-20. Epub 2016/12/06. doi: 10.1016/j.actbio.2016.11.071. PubMed PMID: 27916740; PubMed Central PMC5501313.

Li W, Gorantla S, Gendelman HE, Poluektova LY. Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains. Disease models & mechanisms. 2017;10(12):1489-502. Epub 2017/11/01. doi: 10.1242/dmm.031773. PubMed PMID: 29084769; PubMed Central PMC5769612.

Shahnaz G, Edagwa BJ, McMillan J, Akhtar S, Raza A, Qureshi NA, Yasinzai M, Gendelman HE. Development of mannose-anchored thiolated amphotericin B nanocarriers for treatment of visceral leishmaniasis. Nanomedicine (London, England). 2017;12(2):99-115. Epub 2016/11/24. doi: 10.2217/nnm-2016-0325. PubMed PMID: 27879160; PubMed Central PMC5144491.

Stauch KL, Emanuel K, Lamberty BG, Morsey B, Fox HS. Central nervous system-penetrating antiretrovirals impair energetic reserve in striatal nerve terminals. Journal of neurovirology. 2017;23(6):795-807. Epub 2017/09/13. doi: 10.1007/s13365-017-0573-5. PubMed PMID: 28895059; PubMed Central PMC5726941.

2016

Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA. (2016) Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary. AIDS research and human retroviruses. 32(2):109-19. PubMed PMID: 26670361; PMCID: PMC4761823.

Arainga M, Su H, Poluektova LY, Gorantla S, Gendelman HE. (2016) HIV-1 cellular and tissue replication patterns in infected humanized mice. Scientific reports. 6:23513. PubMed PMID: 26996968; PMCID: PMC4800734.

Bade AN, Gorantla S, Dash PK, Makarov E, Sajja BR, Poluektova LY, Luo J, Gendelman HE, Boska MD, Liu Y. (2016) Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice. Molecular Neurobiology. 53(5):3286-97. PubMed PMID: 26063593; PMCID: PMC4676748.

Dong W, Embury CM, Lu Y, Whitmire SM, Dyavarshetty B, Gelbard HA, Gendelman HE, Kiyota T. (2016) The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation. J Neuroinflammation. 2016 Jul 11;13(1):184. PubMed PMID: 27401058

Embury CM, Dyavarshetty B, Lu Y, Wiederin JL, Ciborowski P, Gendelman HE, Kiyota T. (2016) Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer's Disease. J  Neuroimmune Pharmacol. 2016 Dec 13. PubMed PMID: 27966067

Guo D, Zhou T, Araínga M, Palandri D, Gautam N, Bronich T, Alnouti Y, McMillan J, Edagwa B, Gendelman HE (2016) Creation of a Long-Acting Nanoformulated 2',3'-Dideoxy-3'-Thiacytidine. J Acquir Immune Defic Syndr. 2016 Aug 24. PubMed PMID: 37559685

Ivanisevic J, Stauch KL, Petrascheck M, Benton HP, Epstein AA, Fang M, Gorantla S, Tran M, Hoang L, Kurczy ME, Boska MD, Gendelman HE, Fox HS, Siuzdak G. (2016) Metabolic drift in the aging brain. Aging.  8(5):1000-20. PubMed PMID: 27182841; PMCID: PMC4931850.

Kevadiya BD, Bade AN, Woldstad C, Edagwa BJ, McMillan JM, Sajja BR, Boska MD, Gendelman HE. (2016) Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging. Acta Biomater. 2016 Dec 1. pii: S1742-7061(16)30667-5. doi: 10.1016/j.actbio.2016.11.071. PubMed PMID: 27916740

Li W, Tong HI, Gorantla S, Poluektova LY, Gendelman HE, Lu Y. (2016) Neuropharmacologic Approaches to Restore the Brain's Microenvironment. J Neuroimmune Pharm. 11(3):484-94. PubMed PMID: 27352074; PMCID: PMC4985494.

Olson KE, Bade AN, Schutt CR, Dong J, Shandler SJ, Boska MD, Mosley RL, Gendelman HE, Liu Y. (2016) Manganese-Enhanced Magnetic Resonance Imaging for Detection of Vasoactive Intestinal Peptide Receptor 2 Agonist Therapy in a Model of Parkinson's Disease. Neurotherapeutics. 13(3):635-46.  PubMed PMID: 27329163; PMCID: PMC4965412.

Olson KE, Gendelman HE. (2016) Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease. Current Opinion in Pharm. 26:87-95.  PubMed PMID: 26571205; PMCID: PMC4716884.

Sajja BR, Bade AN, Zhou B, Uberti MG, Gorantla S, Gendelman HE, Boska MD, Liu Y. (2016) Generation and Disease Model Relevance of a Manganese Enhanced Magnetic Resonance Imaging-Based NOD/scid-IL-2Rgammac(null) Mouse Brain Atlas. J Neuroimmune Pharm. 11(1):133-41.  PubMed PMID: 26556033; PMCID: PMC4871948.

Shahnaz G, Edagwa BJ, McMillan J, Akhtar S, Raza A, Qureshi NA, Yasinzai M, Gendelman H. (2016) Development of mannose-anchored thiolated amphotericin B nanocarriers for treatment of visceral leishmaniasis. Nanomedicine (Lond). 2017 Jan;12(2):99-115. PubMed PMID: 27879160.

Singh D, McMillan J, Hilaire J, Gautam N, Palandri D, Alnouti Y, Gendelman HE, Edagwa B. (2016) Development and characterization of a long-acting nanoformulated abacavir prodrug. Nanomedicine (London, England). 11(15):1913-27.  PubMed PMID: 27456759; PMCID: PMC4996153.

Zhang G, Guo D, Dash PK, Arainga M, Wiederin JL, Haverland NA, Knibbe-Hollinger J, Martinez-Skinner A, Ciborowski P, Goodfellow VS, Wysocki TA, Wysocki BJ, Poluektova LY, Liu XM, McMillan JM, Gorantla S, Gelbard HA, Gendelman HE. (2016)The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy. Nanomedicine : nanotechnology, biology, and medicine.  12(1):109-22.  PubMed PMID: 26472049; PMCID: PMC4728028.

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2015

Arainga M, Guo D, Wiederin J, Ciborowski P, McMillan J, Gendelman HE. (2015) Opposing regulation of endolysosomal pathways by long-acting nanoformulated antiretroviral therapy and HIV-1 in human macrophages. Retrovirology. 12:5.  PubMed PMID: 25608975; PMCID: PMC4307176.

Bade AN, Zhou B, McMillan J, Narayanasamy P, Veerubhotla R, Gendelman HE, Boska MD, Liu Y. (2015) Potential of N-acetylated-para-aminosalicylic acid to accelerate manganese enhancement decline for long-term MEMRI in rodent brain. J Neuroscience methods. 251:92-8. PubMed PMID: 26004847; PMCID: PMC4500662.

Benton PH, Ivanisevic J, Rinehart D, Epstein A, Kurczy ME, Boska MD, Gendelman HE, Siuzdak G. (2015)An Interactive Cluster Heat Map to Visualize and Explore Multidimensional Metabolomic Data. Metabolomics. 11(4):1029-34.  PubMed PMID: 26195918; PMCID: PMC4505375.

Gendelman HE, Anantharam V, Bronich T, Ghaisas S, Jin H, Kanthasamy AG, Liu X, McMillan J, Mosley RL, Narasimhan B, Mallapragada SK. (2015) Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases. Nanomedicine : nanotechnology, biology, and medicine.  11(3):751-67. PubMed PMID: 25645958; PMCID: PMC4387001.

Gendelman HE, Mosley RL. A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders. (2015) J Neuroimmune Pharm.  10(4):645-50. PubMed PMID: 26520433; PMCID: PMC4662620.

Ivanisevic J, Siuzdak G. (2015) The Role of Metabolomics in Brain Metabolism Research. J Neuroimmune Pharm. 10(3):391-5.  PubMed PMID: 26201839; PMCID: PMC4546538.

Johnson CH, Patti GJ, Courade JP, Shriver LP, Hoang LT, Manchester M, Siuzdak G. (2015) Alterations in Spinal Cord Metabolism during Treatment of Neuropathic Pain. J Neuroimmune Pharm. 10(3):396-401.  PubMed PMID: 26232265; PMCID: PMC4548716.

Kelso ML, Elliott BR, Haverland NA, Mosley RL, Gendelman HE. (2015) Granulocyte-macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma. J Neuroimmun.  278:162-73. PubMed PMID: 25468272; PMCID: PMC4297700.

Kiyota T, Morrison CM, Tu G, Dyavarshetty B, Weir RA, Zhang G, Xiong H, Gendelman HE. (2015) Presenilin-1 familial Alzheimer's disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice. Brain, behavior, and immunity. 49:311-21.  PubMed PMID: 26112421; PMCID: PMC4567522.

Kiyota T, Zhang G, Morrison CM, Bosch ME, Weir RA, Lu Y, Dong W, Gendelman HE. (2015) AAV2/1 CD74 Gene Transfer Reduces beta-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer's Disease. Molecular Therapy. 23(11):1712-21.  PubMed PMID: 26227349; PMCID: PMC4817947.

Knibbe-Hollinger JS, Fields NR, Chaudoin TR, Epstein AA, Makarov E, Akhter SP, Gorantla S, Bonasera SJ, Gendelman HE, Poluektova LY.  (2015) Influence of age, irradiation and humanization on NSG mouse phenotypes. Biology Open. 4(10):1243-52.  PubMed PMID: 26353862; PMCID: PMC4610222.

Kurczy ME, Zhu ZJ, Ivanisevic J, Schuyler AM, Lalwani K, Santidrian AF, David JM, Giddabasappa A, Roberts AJ, Olivos HJ, O'Brien PJ, Franco L, Fields MW, Paris LP, Friedlander M, Johnson CH, Epstein AA, Gendelman HE, Wood MR, Felding BH, Patti GJ, Spilker ME, Siuzdak G. (2015) Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. Nature Comm. 6:5998.  PubMed PMID: 25601659; PMCID: PMC4454288.

Li T, Gendelman HE, Zhang G, Puligujja P, McMillan JM, Bronich TK, Edagwa B, Liu XM, Boska MD. (2015) Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy. Int J Nanomedicine. 10:3779-90.  PubMed PMID: 26082630; PMCID: PMC4461087.

Mallapragada SK, Brenza TM, McMillan JM, Narasimhan B, Sakaguchi DS, Sharma AD, Zbarska S, Gendelman HE. (2015) Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines. Nanomedicine : nanotechnology, biology, and medicine.  11(3):715-29.  PubMed PMID: 25652894; PMCID: PMC4628726.

Martinez-Skinner AL, Arainga MA, Puligujja P, Palandri DL, Baldridge HM, Edagwa BJ, McMillan JM, Mosley RL, Gendelman HE. (2015) Cellular Responses and Tissue Depots for Nanoformulated Antiretroviral Therapy. PloS One. 10(12):e0145966. Epub 2015/12/31. doi: 10.1371/journal.pone.0145966. PubMed PMID: 26716700; PMCID: PMC4696780.

Mosley RL. (2015) Adaptive Immunity in Neurodegenerative and Neuropsychological Disorders. J Neuroimmune Pharm. 10(4):522-7. PubMed PMID: 26496777.

Olson KE, Kosloski-Bilek LM, Anderson KM, Diggs BJ, Clark BE, Gledhill JM, Jr., Shandler SJ, Mosley RL, Gendelman HE. (2015) Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice. J Neuroscience. 35(50):16463-78.  PubMed PMID: 26674871; PMCID: PMC4679826.

Puligujja P, Arainga M, Dash P, Palandri D, Mosley RL, Gorantla S, Poluektova L, McMillan J, Gendelman HE. (2015) Pharmacodynamics of folic acid receptor targeted antiretroviral nanotherapy in HIV-1-infected humanized mice. Antiviral research. (2015) 120:85-8. PubMed PMID: 26026666; PMCID: PMC4492829.

Puligujja P, Balkundi SS, Kendrick LM, Baldridge HM, Hilaire JR, Bade AN, Dash PK, Zhang G, Poluektova LY, Gorantla S, Liu XM, Ying T, Feng Y, Wang Y, Dimitrov DS, McMillan JM, Gendelman HE. (2015) Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations. Biomaterials.  41:141-50. PubMed PMID: 25522973; PMCID: PMC4272445.

Ross KA, Brenza TM, Binnebose AM, Phanse Y, Kanthasamy AG, Gendelman HE, Salem AK, Bartholomay LC, Bellaire BH, Narasimhan B. Nano-enabled delivery of diverse payloads across complex biological barriers. (2015) J Controlled Release. 219:548-59. PubMed PMID: 26315817; PMCID: PMC4656048.

Zhang J, Garrison JC, Poluektova LY, Bronich TK, Osna NA. (2015) Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics. Biomaterials. 70:37-47. PubMed PMID: 26298393; PMCID: PMC4562313.

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2014

Edagwa BJ, Guo D, Puligujja P, Chen H, McMillan J, Liu X, Gendelman HE, Narayanasamy P (2014) Long-acting antituberculous therapeutic nanoparticles target macrophage endosomes. FASEB J. 28(12):5071-82. PubMed PMID: 25122556. PMCID:  PMC4232285

Gendelman HE, Balogh LP, Bawa R, Bradbury M, Chang EH, Chiu W, Farokhzad O, Foldvari M, Lanza G, Wang K. The 4th Annual Meeting of the American Society for Nanomedicine. J Neuroimmune Pharmacol, 2014. 9 Suppl 1: p. S1-3. PubMed PMID: 24573530. PMCID: PMC3951957

Gendelman HE, Mosley RL, Boska MD, McMillan J (2014) The promise of nanoneuromedicine. Nanomedicine (Lond) 9: 171-176. Publication not peer reviewed

Guo D, Zhang G, Wysocki TA, Wysocki BJ, Gelbard HA, Liu XM, McMillan JM, Gendelman HE (2014) Endosomal Trafficking of Nanoformulated Antiretroviral Therapy Facilitates Drug Particle Carriage and HIV Clearance. J Virol 88: 9504-9513. PubMed PMID: 24920821. PMCID: PMC4136325.

Nel, A., S. Swindells, T. Bronich, and H.E. Gendelman, Interview: Nanomedicine and the fight against HIV/AIDS. Nanomedicine (Lond), 2014. 9(2): p. 193-206. Publication not peer reviewed.

Singh D, McMillan JM, Kabanov AV, Sokolsky-Papkov M, Gendelman HE (2014) Bench-to-bedside translation of magnetic nanoparticles. Nanomedicine (Lond) 9: 501-516. PubMed PMID: 24910878. PMCID: PMC4150086

Singh D, McMillan JM, Liu XM, Vishwasrao HM, Kabanov AV, Sokolsky-Papkov M, Gendelman HE (2014) Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues. Nanomedicine (Lond) 9: 469-485. PubMed PMID: 24646020. PMCID:  PMC4338921

Edagwa BJ, Zhou T, McMillan JM, Liu XM, Gendelman HE. (2014) Development of HIV reservoir targeted long acting nanoformulated antiretroviral therapies.  Curr Med Chem. 21(36):4186-98. PubMed PMID: 25174930. PMCID: PMC4281174

Kurczy ME, Zhu, XJ, Ivanisevic J, Schuyler AM, Lalwani K, Santidrian AF, David JW, Giddabasappa A, Roberts A, Olivos HJ, O'Brien PJ, Franco L, Fields MW, Paris LP, Friedlander M, Johnson CH, Epstein A, Gendelman HE, Wood M, Felding-Habermann B, Patti GJ, Spilker ME, Siuzdak G. (2014) Comprehensive bio-imaging with fluorinated nanoparticles using breathable liquids. Nature Communications. 6:5998 PubMed PMID: 25601659. PMCID:  PMC4454288

Ivanisevic J, Benton HP, Rinehart D, Epstein A, Kurczy ME, Boska MD, Gendelman HE, Siuzdak G. (2014) An interactive cluster heat map to visualize and explore multidimensional metabolomic data.  Metabolomics. 11(4):1029-1034. PubMed PMID: 26195918. PMCID: PMC4505375

Gautam N, Puligujja P, Balkundi S, Thakare R, Liu XM, Fox HS, McMillan J, Gendelman HE, Alnouti Y (2014) Pharmacokinetics, biodistribution, and toxicity of folic Acid-coated antiretroviral nanoformulations. Antimicrob Agents Chemother 58(12):7510-9. PubMed PMID: 25288084. PMCID: PMC4249580

Ivanisevic J, Epstein AA, Kurczy ME, Benton PH, Uritboonthai W, Fox HS, Boska MD, Gendelman HE, Siuzdak G. (2014) Brain Region Mapping Using Global Metabolomics. Chem Biol. 21(11):1575-1584.  PubMed PMID: 25457182. PMCID: PMC4304924

Kelso ML, Elliott BR, Haverland NA, Mosley RL, Gendelman HE. (2014) Granulocyte-Macrophage Colony Stimulating Factor Exerts Protective and Immunomodulatory Effects in Cortical Trauma. pii: S0165-5728(14)00948-5. PubMed PMID: 25468272. PMCID: PMC4297700

Gerson T, Makarov E, Senanayake TH, Gorantla S, Poluektova LY, Vinogradov SV. (2014) Nano-NRTIs demonstrate low neurotoxicity and high antiviral activity against HIV infection in the brain. Nanomedicine. 0(1):177-85. PubMed PMID: 23845925. PMCID: PMC3843977

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2013

Bade AN, Zhou B, Epstein AA, Gorantla S, Poluektova LY, Luo J, Gendelman HE, Boska MD, Liu Y (2013) Improved visualization of neuronal injury following glial activation by manganese enhanced MRI. J Neuroimmune Pharmacol 8: 1027-1036. PubMed PMID: 23729245; PMCID: PMC3746563.

Epstein AA, Narayanasamy P, Dash PK, High R, Bathena SP, Gorantla S, Poluektova LY, Alnouti Y, Gendelman HE, Boska MD (2013) Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection. J Neuroimmune Pharmacol 8: 1224-1238. PubMed PMID: 23702663; PMCID: PMC3889226.

Gautam N, Bathena SP, Chen Q, Natarajan A, Alnouti Y (2013) Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-kappaB inhibitor in mice and rats by LC-MS/MS. Biomed Chromatogr 27: 900-909. PubMed PMID: 23483555; PMCID: PMC3760428.

Gautam N, Roy U, Balkundi S, Puligujja P, Guo D, Smith N, Liu XM, Lamberty B, Morsey B, Fox HS, McMillan J, Gendelman HE, Alnouti Y (2013) Preclinical pharmacokinetics and tissue distribution of long-acting nanoformulated antiretroviral therapy. Antimicrob Agents Chemother 57: 3110-3120. PubMed PMID: 23612193; PMCID: PMC3697338.

Gelbard HA, Gendelman HE (2013) Lipids and cognition make good bedfellows for neuroAIDS. Neurology 81: 1480-1481. Publication not peer reviewed

Guo D, Li T, McMillan J, Sajja BR, Puligujja P, Boska MD, Gendelman HE, Liu XM (2013) Small magnetite antiretroviral therapeutic nanoparticle probes for MRI of drug biodistribution. Nanomedicine (Lond): PubMed PMID: 23905578; PMCID: PMC3909560.

Haney MJ, Zhao Y, Harrison EB, Mahajan V, Ahmed S, He Z, Suresh P, Hingtgen SD, Klyachko NL, Mosley RL, Gendelman HE, Kabanov AV, Batrakova EV (2013) Specific transfection of inflamed brain by macrophages: a new therapeutic strategy for neurodegenerative diseases. PLoS One 8: e61852. PubMed PMID: 23620794; PMCID: PMC3631190.

Klyachko NL, Haney MJ, Zhao Y, Manickam DS, Mahajan V, Suresh P, Hingtgen SD, Mosley RL, Gendelman HE, Kabanov AV, Batrakova EV (2013) Macrophages offer a paradigm switch for CNS delivery of therapeutic proteins. Nanomedicine (Lond): PubMed PMID: 24237263; PMCID: PMC4025996.

Kosloski LM, Kosmacek EA, Olson KE, Mosley RL, Gendelman HE. (2013) GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice. J Neuroimmunol. 265(1-2):1-10. PubMed PMID: 24210793; PMCID:  PMC3872482

Liu Y, Sajja BR, Gendelman HE, Boska MD (2013) Mouse brain fixation to preserve In vivo manganese enhancement for ex vivo manganese-enhanced MRI. J Magn Reson Imaging 38: 482-487. PubMed PMID: 23349027; PMCID: PMC3638066.

Ma Q, Gelbard HA, Maggirwar SB, Dewhurst S, Gendelman HE, Peterson DR, DiFrancesco R, Hochreiter JS, Morse GD, Schifitto G (2013) Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients. J Neurovirol 19: 254-260. PubMed PMID: 23737347; PMCID: PMC3760277.

Martinez-Skinner AL, Veerubhotla RS, Liu H, Xiong H, Yu F, McMillan JM, Gendelman HE (2013) Functional proteome of macrophage carried nanoformulated antiretroviral therapy demonstrates enhanced particle carrying capacity. J Proteome Res 12: 2282-2294. PubMed PMID: 23544708; PMCID: PMC3664030.

Nowacek A, Kadiu I, McMillan J, Gendelman HE (2013) Immunoisolation of nanoparticles containing endocytic vesicles for drug quantitation. Methods Mol Biol 991: 41-46. PubMed PMID: 23546657; PMCID: PMC3930998.

Nowacek A, Kadiu I, McMillan J, Gendelman HE (2013) Methods for isolation and identification of nanoparticle-containing subcellular compartments. Methods Mol Biol 991: 47-55. PubMed PMID: 23546658; PMCID: PMC4008930

Puligujja P, McMillan J, Kendrick L, Li T, Balkundi S, Smith N, Veerubhotla RS, Edagwa BJ, Kabanov AV, Bronich T, Gendelman HE, Liu XM (2013) Macrophage folate receptor-targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution for reduction of human immunodeficiency virus infections. Nanomedicine 9: 1263-1273. PubMed PMID: 23680933; PMCID: PMC3779529.

Williams J, Sayles HR, Meza JL, Sayre P, Sandkovsky U, Gendelman HE, Flexner C, Swindells S (2013) Long-acting parenteral nanoformulated antiretroviral therapy: interest and attitudes of HIV-infected patients. Nanomedicine (Lond) 8: 1807-1813. PubMed PMID: 23611617; PMCID: PMC3987826.

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2012

Bathena SP, Huang J, Epstein AA, Gendelman HE, Boska MD, Alnouti Y (2012) Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 893-894: 15-20. PubMed PMID: 22425384; PMCID: PMC3322302.

Dash PK, Gendelman HE, Roy U, Balkundi S, Alnouti Y, Mosley RL, Gelbard HA, McMillan J, Gorantla S, Poluektova LY (2012) Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice. AIDS 26: 2135-2144. PubMed PMID: 22824628; PMCID: PMC4024396.

Fox HS, Gendelman HE (2012) Commentary: Animal models of neuroAIDS. J Neuroimmune Pharmacol 7: 301-305. PubMed PMID: 22549136; PMCID: PMC3915784.

Gorantla S, Gendelman HE, Poluektova LY (2012) Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders? J Neuroimmune Pharmacol 7: 352-362. PubMed PMID: 22222956; PMCID: PMC3782112.

Gorantla S, Poluektova L, Gendelman HE (2012) Rodent models for HIV-associated neurocognitive disorders. Trends Neurosci 35: 197-208. PubMed PMID: 22305769; PMCID: PMC3294256.

Grant KM, LeVan TD, Wells SM, Li M, Stoltenberg SF, Gendelman HE, Carlo G, Bevins RA (2012) Methamphetamine-associated psychosis. J Neuroimmune Pharmacol 7: 113-139. PubMed PMID: 21728034; PMCID: PMC3280383.

Haney MJ, Suresh P, Zhao Y, Kanmogne GD, Kadiu I, Sokolsky-Papkov M, Klyachko NL, Mosley RL, Kabanov AV, Gendelman HE, Batrakova EV (2012) Blood-borne macrophage-neural cell interactions hitchhike on endosome networks for cell-based nanozyme brain delivery. Nanomedicine (Lond) 7: 815-833. PubMed PMID: 22236307; PMCID: PMC3384770.

Kadiu I, Narayanasamy P, Dash PK, Zhang W, Gendelman HE (2012) Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. J Immunol 189: 744-754. PubMed PMID: 22711894; PMCID: PMC3786185.

Kanmogne GD, Singh S, Roy U, Liu X, McMillan J, Gorantla S, Balkundi S, Smith N, Alnouti Y, Gautam N, Zhou Y, Poluektova L, Kabanov A, Bronich T, Gendelman HE (2012) Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells. Int J Nanomedicine 7: 2373-2388. PubMed PMID: 22661891; PMCID: PMC3357981.

Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T (2012) The effect of HIV protease inhibitors on amyloid-beta peptide degradation and synthesis in human cells and Alzheimer's disease animal model. J Neuroimmune Pharmacol 7: 412-423. PubMed PMID: 21826404; PMCID: PMC3223330.

Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, 3rd, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD (2012) A call for transparent reporting to optimize the predictive value of preclinical research. Nature 490: 187-191. PubMed PMID: 23060188; PMCID: PMC3511845.

Liu Y, Sajja BR, Uberti MG, Gendelman HE, Kielian T, Boska MD (2012) Landmark optimization using local curvature for point-based nonlinear rodent brain image registration. Int J Biomed Imaging 2012: 635207. PubMed PMID: 21966289; PMCID: PMC3180176.

Pottiez G, Jagadish T, Yu F, Letendre S, Ellis R, Duarte NA, Grant I, Gendelman HE, Fox HS, Ciborowski P (2012) Plasma proteomic profiling in HIV-1 infected methamphetamine abusers. PLoS One 7: e31031. PubMed PMID: 22359561; PMCID: PMC3281056.

Roy U, McMillan J, Alnouti Y, Gautum N, Smith N, Balkundi S, Dash P, Gorantla S, Martinez-Skinner A, Meza J, Kanmogne G, Swindells S, Cohen SM, Mosley RL, Poluektova L, Gendelman HE (2012) Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice. J Infect Dis 206: 1577-1588. PubMed PMID: 22811299; PMCID: PMC3570176.

Wiederin JL, Yu F, Donahoe RM, Fox HS, Ciborowski P, Gendelman HE (2012) Changes in the plasma proteome follows chronic opiate administration in simian immunodeficiency virus infected rhesus macaques. Drug Alcohol Depend 120: 105-112. PubMed PMID: 21821369; PMCID: PMC3245805.

Yannam GR, Gutti T, Poluektova LY (2012) IL-23 in infections, inflammation, autoimmunity and cancer: possible role in HIV-1 and AIDS. J Neuroimmune Pharmacol 7: 95-112. PubMed PMID: 21947740; PMCID: PMC3288567.

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2011

Batrakova EV, Gendelman HE, Kabanov AV (2011) Cell-mediated drug delivery. Expert Opin Drug Deliv 8: 415-433. PubMed PMID: 21348773; PMCID: PMC3062753.

Bressani RF, Nowacek AS, Singh S, Balkundi S, Rabinow B, McMillan J, Gendelman HE, Kanmogne GD (2011) Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage. Nanotoxicology 5: 592-605. PubMed PMID: 21175298; PMCID: PMC3715104

Dash PK, Gorantla S, Gendelman HE, Knibbe J, Casale GP, Makarov E, Epstein AA, Gelbard HA, Boska MD, Poluektova LY (2011) Loss of neuronal integrity during progressive HIV-1 infection of humanized mice. J Neurosci 31: 3148-3157. PubMed PMID: 21368026; PMCID: PMC3059783.

Gong N, Liu J, Reynolds AD, Gorantla S, Mosley RL, Gendelman HE. (2011) Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis. J Neuroimmunol. 230(1-2): p. 33-41. PubMed PMID: 20846730; PMCID: PMC3003943.

Haney MJ, Zhao Y, Li S, Higginbotham SM, Booth SL, Han HY, Vetro JA, Mosley RL, Kabanov AV, Gendelman HE, Batrakova EV (2011) Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells. Nanomedicine (Lond) 6: 1215-1230. PubMed PMID: 21449849; PMCID: PMC3166447.

Huang J, Gautam N, Bathena SP, Roy U, McMillan J, Gendelman HE, Alnouti Y. (2011) UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. 879(23): p. 2332-8. PubMed PMID: 21752731; PMCID: PMC3144699.

Kadiu I, Nowacek A, McMillan J, Gendelman HE (2011) Macrophage endocytic trafficking of antiretroviral nanoparticles. Nanomedicine (Lond) 6: 975-994. PubMed PMID: 21417829; PMCID: PMC3184214.

Nowacek AS, Balkundi S, McMillan J, Roy U, Martinez-Skinner A, Mosley RL, Kanmogne G, Kabanov AV, Bronich T, Gendelman HE (2011) Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages. J Control Release 150: 204-211. PubMed PMID: 21108978; PMCID: PMC3065529.

Zhao Y, Haney MJ, Klyachko NL, Li S, Booth SL, Higginbotham SM, Jones J, Zimmerman MC, Mosley RL, Kabanov AV, Gendelman HE, Batrakova EV (2011) Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles. Nanomedicine (Lond) 6: 25-42. PubMed PMID: 21182416; PMCID: PMC3037278.

Balkundi S, Nowacek AS, Veerubhotla RS, Chen H, Martinez-Skinner A, Roy U, Mosley RL, Kanmogne G, Liu X, Kabanov AV, Bronich T, McMillan J, Gendelman HE (2011) Comparative manufacture and cell-based delivery of antiretroviral nanoformulations. Int J Nanomedicine 6: 3393-3404. PubMed PMID: 22267924; PMCID: PMC3260033.

Bathena SP, Huang J, Nunn ME, Miyamoto T, Parrish LC, Lang MS, McVaney TP, Toews ML, Cerutis DR, Alnouti Y (2011) Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS. J Pharm Biomed Anal 56: 402-407. PubMed PMID: 21703797; PMCID: PMC3134166.

Kadiu I, Gendelman HE (2011) Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network. J Proteome Res 10: 3225-3238. PubMed PMID: 21563830; PMCID: PMC3128463.

Kadiu I, Gendelman HE (2011) Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection. J Neuroimmune Pharmacol 6: 658-675. PubMed PMID: 21789505; PMCID: PMC3232570.

Kraft-Terry SD, Engebretsen IL, Bastola DK, Fox HS, Ciborowski P, Gendelman HE (2011) Pulsed stable isotope labeling of amino acids in cell culture uncovers the dynamic interactions between HIV-1 and the monocyte-derived macrophage. J Proteome Res 10: 2852-2862. PubMed PMID: 21500866; PMCID: PMC3108467.

Kraft-Terry SD, Gendelman HE (2011) Proteomic biosignatures for monocyte-macrophage differentiation. Cell Immunol 271: 239-255. PubMed PMID: 21788015; PMCID: PMC3195886.

McMillan J, Batrakova E, Gendelman HE (2011) Cell delivery of therapeutic nanoparticles. Prog Mol Biol Transl Sci 104: 563-601. PubMed PMID: 22093229; PMCID: PMC4016803.

Zhao Y, Haney MJ, Mahajan V, Reiner BC, Dunaevsky A, Mosley RL, Kabanov AV, Gendelman HE, Batrakova EV (2011) Active Targeted Macrophage-mediated Delivery of Catalase to Affected Brain Regions in Models of Parkinson's Disease. J Nanomed Nanotechnol S4: PubMed PMID: 22288024; PMCID: PMC3267477.

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2010

Balkundi S, Nowacek AS, Roy U, Martinez-Skinner A, McMillan J, Gendelman HE (2010) Methods development for blood borne macrophage carriage of nanoformulated antiretroviral drugs. J Vis Exp: PubMed PMID: 21178968; PMCID: PMC3052269.

Boska M, Liu Y, Uberti M, Sajja BR, Balkundi S, McMillan J, Gendelman HE (2010) Registered bioimaging of nanomaterials for diagnostic and therapeutic monitoring. J Vis Exp: (46). pii: 2459 PubMed PMID: 21178969; PMCID: PMC3052268.

Gorantla S, Makarov E, Finke-Dwyer J, Castanedo A, Holguin A, Gebhart CL, Gendelman HE, Poluektova L (2010) Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis. Am J Pathol 177: 2938-2949. PubMed PMID: 21088215; PMCID: PMC2993281.

Huang J, Bathena SP, Alnouti Y (2010) Metabolite profiling of praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple quadrupole linear ion trap mass spectrometer. Drug Metab Pharmacokinet 25: 487-499. Not directly funded by NIH.

Huang X, Stone DK, Yu F, Zeng Y, Gendelman HE. (2010) Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage. J Proteome Res  9(12): p. 6759-73. PubMed PMID: 20954747; PMCID: PMC3108468

Kraft-Terry S, Gerena Y, Wojna V, Plaud-Valentin M, Rodriguez Y, Ciborowski P, Mayo R, Skolasky R, Gendelman HE, Melendez LM (2010) Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants. Proteomics Clin Appl 4: 706-714. PubMed PMID: 21137088; PMCID: PMC3098323.

Nowacek, A.S., J. McMillan, R. Miller, A. Anderson, B. Rabinow, and H.E. Gendelman, Nanoformulated antiretroviral drug combinations extend drug release and antiretroviral responses in HIV-1-infected macrophages: implications for neuroAIDS therapeutics. J Neuroimmune Pharmacol, 2010. 5(4): p. 592-601. PubMed PMID: 20237859; PMCID: PMC3401515

Quan LD, Yuan F, Liu XM, Huang JG, Alnouti Y, Wang D (2010) Pharmacokinetic and biodistribution studies of N-(2-hydroxypropyl)methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model. Mol Pharm 7: 1041-1049.PMID: 20557133. PubMed PMID: 20557133; PMCID: PMC2914173.

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Book Chapters

Fox HS. HIV-1 and Methamphetamine. In: The Neurology of AIDS 3rd Edition. Eds. Gendelman HE, Everall I, Fox H, Grant I, Lipton S, Swindells S. In Press, Oxford University Press, Oxford, 2011.

Martinez-Skinner A, Nowacek A, McMillan J, Gendelman HE.  Mononuclear phagocytes as vehicles for viral dissemination, cellular viral reservoirs, and immune effectors in the neuropathogenesis of HIV-1 infection.  In: The Neurology of AIDS 3rd Edition. Eds. Gendelman HE, Everall I, Fox H, Grant I, Lipton S, Swindells S. In Press, Oxford University Press, Oxford, 2011/

Nowacek A, Zhang G, McMillan J, Kiyota T, Batrakova E, Gendelman, HE. Nanomedicine and Neurodegenerative Disorders. In: Nanomedicine in Health and Disease, eds. Hunter and Preedy, Science Publishers, an imprint of Edenridge Ltd., Enfield, NH, pp 377-397, 2011.

Roy U, Balkundi S, McMillan J, Gendelman HE. Nanomedicine to improve central nervous system drug delivery in neuroAIDS. In: The Neurology of AIDS 3rd Edition. Eds. Gendelman HE, Everall, I, Fox H, Grant I, Lipton S, Swindells S. In Press, Oxford University Press, Oxford, 2011.

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Books

T. Ikezu and H. E. Gendelman. “Neuroimmune Pharmacology, Second Edition” Springer 2016 (ISBN: 978-3-319-44020-0).

L. Poluektova, J. Larisa Y. Poluektova, J. Victor Garcia-Martinez, Yoshio Koyanagi, Markus G. Manz, Andrew M. Tager. "Humanized Mice for HIV Research," Springer 2015 (ISBN: 978-1-4939-1654-2)

H. Xiong and H. E. Gendelman. “Current Laboratory Methods in Neuroscience, Springer 2013 (ISBN: 978-1-4614-8794-4).

H. E. Gendelman, I. Grant, I. P. Everall, H. S. Fox, H. A. Gelbard, S. A. Lipton and S. Swindells. “The Neurology of AIDS Third Edition,” Oxford University Press. Nov 2011 (ISBN: 978-0-19-539934-9).

T. Ikezu and H. E. Gendelman. “Neuroimmune Pharmacology,” Springer 2008 (ISBN: 978-0-3877-2572-7).