Neural Immunity in HIV Dementia - Publications

2011

Balkundi, S., Nowacek, A.S., Veerubhotla, R.S., Chen, H., Martinez-Skinner, A., Roy, U., Mosley, R.L., Kanmogne, G., Liu, X., Kabanov, A.V., Bronich, T., McMillan, J., Gendelman, H.E. Comparative Manufacture and Cell-based Delivery of Antiretroviral Nanoformulations.  Intl J. Nanomedicine, 2011:6 1-12. PMCID: PMC Journal – In Process

Batrakova, E.V., Gendelman, H.E., Kabanov, A.V. Cell-mediated drug delivery. Expert Opin Drug Deliv. 2011 Apr;8(4):415-33. Epub 2011 Feb 24. PMCID:PMC3062753.

Dash, P., Gorantla, S., Roy, U., Balkundi, S., Mosley, R.L., McMillan, J., Gelbard, H.A., Gendelman, H.E., Poluektova, L.  Safety and Efficacy of Injectable Long-Acting Antiretroviral Nanoformulations in HIV-1 Infected Humanized Mice.  Submitted, Journal of Clinical Investigation, 2012.

Dash, P.K., Gorantla, S., Gendelman, H.E., Knibbe, J., Casale, G.P., Makarov, E., Epstein, A.A., Gelbard, H.A., Boska, MD, Poluektova, L.Y. Loss of Neuronal Integrity During Progressive HIV-1 Infection of Humanized Mice. J. Neuroscience. 2011 Mar 2;31(9):3148-57. PMCID: PMC3059783

Gendelman, H.E. and Appel, S.H.  Neuroprotective activities of regulatory T cells.  Trends in Molecular Medicine, 2011 Dec; 17(12):687-8. PMC Journal – in Process.

Gorantla, S., Gendelman, H.E., Poluektova L.  Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders?  J Neuroimmune Pharmacol, 2011. 7(2):352-62. PMCID: PMC Journal – in Process

Gorantla, S., Poluektova, L., Gendelman, H.E. Rodent Models for HIV-associated Neurocognitive Disorders.Trends in Neurosciences, 2011. 35(3):197-208. PMCID: PMC 3294256

Grant, K.M., Levan, T.D., Wells, S.M., Li, M., Stoltenberg, S.F., Gendelman, H.E., Carlo, G., Bevins, R.A.  Methamphetamine-Associated Psychosis.  J Neuroimmune Pharmacol. 2011 Jul 5 [Epub ahead of print]. PMC Journal – in process

Handler, M.Z., Miriovsky, B., Gendelman, H.E., Sandkovsky, U. Fusobacterium necrophorum causing infective endocarditis and liver and splenic abscesses. Rev Inst Med Trop São Paulo. 2011 June;53(3):169-72. Review. (not peer reviewed).

Haney, M.J., Suresh, P., Zhao, Y., Kanmogne, G.D., Kadiu, I., Klyachoko, N.L., Mosley, R.L. Kabanov, A., Gendelman, H.E., and Batrakova, E.V. Blood-borne macrophage neural cell interactions facilitates trafficking of nanozymes in cell-based drug delivery. In press, Nanomedicine (Lond), 2012 7(6):815-33. PMCID: PMC3384770

Haney, M.J., Zhao, Y., Li, S., Higginbotham, S.M., Booth, S.L., Han, Y.Y., Vetro, J.A., Mosley, R.L., Kabanov, A.V., Gendelman, H.E., Batrokova. E. Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells: Implications for nanomedicine drug delivery to the central nervous system, Nanomedicine (London). 2011 Sep;6(7):1215-30. PMCID: PMC3166447

Huang, J., Gautam, N., Bathena, S.P., Roy, U., McMillan, J., Gendelman, H.E., Alnouti, Y. UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Aug 1;879(23):2332-8. PMCID: PMC3144699

Hutter-Saunder, J.A., Gendelman, H.E., Mosley, R.L. Murine Motor and Behavior Functional Evaluations for Acute 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Intoxication. J. Neuroimmune Pharm.  2012 7(1):279-88  PMCID: PMC3392900

Hutter-Saunder, J.A.L., Kosloski, L.M., McMillan, J.E., Yotam, N., Rinat, T., Mosley, R.L., Gendelman, H.E. BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice. Neuroscience. 2011 Apr 28;180:293-304. Epub 2011 Feb 12. PMCID:PMC3070792

Hutter-Saunders, J.A., Mosley, R.L., Gendelman, H.E. Pathways towards an Effective Immunotherapy for Parkinson’s disease.  Expert Rev Neurother. 2011 Dec; 11(12):1703-15. PMCID: PMC3263336

Hutter, J.A.L., Poluektova, L., Dhawan, S., Gendelman, H.E. Adaptive Immunity.   In:  The Neurology of AIDS, Third Edition. Eds: H.E. Gendelman, I.P. Everall, H.S. Fox, H.A. Gelbard, I. Grant, S.A. Lipton, S. Swindells. Oxford University Press, New York, 2011, pp 131-145 (not peer reviewed).

Kadiu, I, Gendelman, H.E. Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network. J Proteome Res. 2011 Jul 1;10(7):3225-38 PMCID: PMC3128463

Kadiu, I., Gendelman, H.E. Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection.  J. Neuroimmune Pharmacol. 2011 Dec;6(4):658-75. PMCID: PMC Journal – in Process

Kadiu, I., Nowacek, A., McMillan, J., Gendelman, H.E. Macrophage endocytic trafficking of antiretroviral nanoparticles. Nanomedicine (Lond). 2011 Aug;6(6):975-94 PMCID: PMC3184214

Kanmogne, G.D., Singh, S., Roy, U., Liu, X., McMillan, J., Gorantla, S., Balkundi, S., Smith, N., Alnouti, Y., Gautam, N., Zhou, Y., Poluektova, L., Kabanov, A., Bronich, T., Gendelman, H.E. Mononuclear Phagocyte Intercellular Crosstalk Facilites Transmission of Cell Targeted Nanoformulated Antiretroviral Drugs to Human Brain Endothelial Cells.  Submitted, Intl J of Nanomedicine, 2012.

Kraft-Terry, S. and Gendelman, H.E.  Proteomic Biosignatures for Monocyte-Macrophage Differentiation. Cellular Immunology, 2011;271(2):239-55 PMCID: PMC3195886

Kraft-Terry, S. Gerena, Y., Wojna, V., Plaud-Valentin, M., Rodriguez, Y., Ciborowski, P., Mayo, R., Skolasky, R., Gendelman, H.E., Melendez, L.M. Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants. Proteomics Clin Appl. 2010 September; 4(8-9):76-714 PMCID: PMC3098323

Kraft-Terry, S., Engebretsen, I.L., Bastola, D.K., Fox, H.S., Ciborowski, P., Gendelman, H.E.  Pulsed Stable Isotope Labeling of Amino Acids in Cell Culture Uncovers the Dynamic Interactions between HIV-1 and the Monocyte-Derived Macrophage. J Proteome Res. 2011 June 3;10(6):2852-2862. Published online 2011 April 18. PMCID:PMC3108467

Liu, Y., Sajja, B., Uberti, M., Gendelman, H.E., Kielian, T.L., Boska, M. Landmark Optimization Using Local Curvature for Point-Based Nonlinear Rodent Brain Image Registration. International Journal of Biomedical Imaging, 2012;2012:635207 Epub 2011 Sep 26. vol. 2012, 8 pgs. PMCID:PMC3180176

Martinez-Skinner, A., Nowacek, A., McMillan, J., Gendelman, H.E. Mononuclear phagocytes as vehicles for viral dissemination, cellular viral reservoirs, and immune effectors in the neuropathogenesis of HIV-1 infection.  In:  The Neurology of AIDS, Third Edition. Eds: H.E. Gendelman, I.P. Everall, H.S. Fox, H.A. Gelbard, I. Grant, S.A. Lipton, S. Swindells. Oxford University Press, New York, 2011, pp 257-274 (not peer reviewed).

McMillan, J., Batrakova, E., Gendelman, H.E. Cell Delivery of Therapeutic Nanoparticles.  Prog Mol Biol Transi Sci. 2011;104:563-601.

Nowacek, A., Batrakova, E.V., McMillan, J., Gang, N., Gendelman, H.E. Nanomedicine and neurodegenerative disorders. In Nanomedicine in Health and Disease. Oxford University Press: New York, in press 2011. Publication not peer reviewed.

Nowacek, A., Zhang, G., McMillan, J., Kiyota, T., Batrakova, E. and Gendelman, H.E. Nanomedicine and Neurodegenerative Disorders.  InNanomedicine in Health and Disease, eds. Hunter and Preedy, Science Publishers, an imprint of Edenridge Ltd., Enfield, NH, pp 377-397, 2011. Publication not peer reviewed.

Nowacek, A., Zhang, G., McMillan, J., Kiyota, T., Batrakova, E., Gendelman, H.E.  Nanomedicine and Neurodegenerative Disorders. In: Nanomedicine in Health and Disease. pp. 377-397. 2011. Ed. Victor R. Preedy, Elsevier, Oxford, UK.

Roy, U, Balkundi S., McMillan, J., Gendelman, H.E. Nanomedicine to improve central nervous system drug delivery in neuroAIDS.  In:  The Neurology of AIDS, Third Edition. Eds: H.E. Gendelman, I.P. Everall, H.S. Fox, H.A. Gelbard, I. Grant, S.A. Lipton, S. Swindells. Oxford University Press, New York, 2011, pp 987-998 (not peer reviewed).

Roy, U., McMillan, J., Alnouti, Y., Gautum, N., Smith, N., Balkundi, S., Dash, P., Gorantla, S., Martinez-Skinner, A., Meza, J., Kanmogne, G., Swindells, S., Cohen, S.M., Mosley, R.L., Poluektova, L., Gendelman, H.E. Pharmacodynamic and Antiretroviral Activities of Combination Nanoformulated Antiretrovirals in HIV-1-Infected Human PBL-Reconstituted Mice. Submitted, J. Infect. Dis., 2011.

Wiederin, J.L., Yu, F., Donahoe, R.M., Fox, H.S., Ciborowski, P., Gendelman, H.E. Changes in the plasma proteome follows chronic opiate administration in simian immunodeficiency virus infected rhesus macaques. Drug Alcohol Depend. 2011 Aug 5 [Epub ahead of print]. PMC Journal – in Process.

Yannam GR, Gutti T, Poluektova LY. IL-23 in Infections, Inflammation, Autoimmunity and Cancer: Possible Role in HIV-1 and AIDS. J Neuroimmune Pharmacol. 2011 Sep 24. [Epub ahead of print] PMCID: PMC Journal in Process

Zhao, Y., Haney, M.J., Klyachko, N.L., Li, S., Booth, S.L., Higginbotham, S.M., Jones, J., Zimmerman, M.C., Mosley, R.L., Kabanov, A.V., Gendelman, H.E., Batrakova, E.L. Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles. Nanomedicine (London). 2011 Jan;6(1):25-42. PMCID: PMC3037278

2010

Balkundi, S., Nowacek, A.S., Roy, U., Martinez-Skinner, A., McMillan, J. Gendelman, H.E. Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs. Journal of Visualized Experiments (JoVE). 9;(46). pii: 2460.PMC Journal – In Process

Boska, M., Liu, Y., Uberti, M., Saija, B.R., Balkundi, S., McMillan, J., Gendelman, H.E. Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring. Journal of Visualized Experiments (JoVE). 9;(46). pii: 2459. PMC Journal – In Process

Bressani, R.F., Nowacek, A.S., Singh, S., Balkundi, S., Rabinow, B., McMillan, J., Gendelman, H.E., Kanmogne, G.D. Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage. Nanotoxicology. In Press. PMC Journal – In Process

Brynskikh, A.M., Zhao, Y., Mosley, R.L., Li, S., Boska, MD, Klyachko, N.L., Kabanov, A.V., Gendelman, H.E. and Batrakova, E.V. Macrophage delivery of therapeutic nanozymes in a murine model of Parkinson’s disease. Nanomedicine (Lond). 2010 Apr;5(3):379-96. PMCID: PMC2880389

Cui, M., Huang, Y., Tian, C., Zhao, Y., Zheng, J. FOXO3a Inhibits TNF-a- and IL-1b-Induced Astrocyte Proliferation: Implication for Reactive Astrogliosis. Glia, 59(4):641-54. PMC Journal – In Process

Dash, P.K., Gorantla, S., Gendelman, H.E., Knibbe, J., Casale, G.P., Makarov, E., Epstein, A.A., Gelbard, H.A., Boska, MD, Poluektova, L.Y. Loss of Neuronal Integrity During Progressive HIV-1 Infection of Humanized Mice. In Press J. Neuroscience. 2010. PMC Journal – In Process

Eggert, D., Dash, P.K., Gorantla, S., Dou, H., Schifitto, G., Maggirwar, S.B., Dewhurst, S., Poluektova L., Gelbard, H.A., and Gendelman, H.E. Neuroprotective Activities of CEP-1347 in Models of NeuroAIDS. J. Immunol. 2010 184(2):746-56. PMCID:PMC2805820

Gong, N., Liu, J., Reynolds, A.D., Gorantla, S., Mosley, R.L. and Gendelman, H.E. Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis. J Neuroimmunol. 184(2): 746–756, 2010 PMCID: PMC2805820

Gorantla, S., Makarov, E., Finke-Dwyer, J., Castanedo, A., Holguin, A., Gebhart, C.L., Gendelman, H.E., Poluektova, L. Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis. Am J Pathol. 2010 Dec;177(6):2938-49. PMCID: PMC2993281

Gorantla, S., Makarov, E., Finke-Dwyer, J., Gebhart, C.L., Domm, W., Dewhurst, S., Gendelman, H.E. and Poluektova, L.Y. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol. 2010 Jun 15;184(12):7082-91 Epub 2010 May 21. PMCID: PMC3008566.

Gorantla, S., Makarov, E., Finke-Dwyer, J., Castanedo, A., Holguin, A., Gebhart, C.L., Gendelman, H.E., Poluektova, L. Links between Progressive HIV-1 Infection of Humanized Mice and Viral Neuropathogenesis. Am J Pathol. 2010 Dec;177(6):2938-49. PMCID: PMC2993281

Huang, X., Stone, D.K., Yu, F., Zeng, Y., Gendelman, H.E. Functional Proteomic Analysis for Regulatory T Cell Surveillance of the HIV-1-Infectioned Macrophage. J Proteome Res. 2010 Dec 3;9(12):6759-73. PMCID: PMC2997194

Hutter, J., Poluektova, L.Y., Dhawan, S.,and Gendelman, H.E. Adaptive Immunity Links NeuroAIDS with other Neurodegenerative Diseases. In The Neurology of AIDS, 3rd Edition, Eds. H.E. Gendelman, I. P. Everall, H. Fox, H. Gelbard, I Grant, S. Lipton S Swindells. Springer, NY. In press 2011

Kiyota, T., Okuyama, S, Swan, R.J., Jacobsen, MT, Gendelman, H.E. and Ikezu, T. CNS expression of anti-inflammatory cytokine interleukin-r-attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice. FASEB J 2010 Aug;24(8):3093-102. PMCID: PMC2909296

Kosloski, L.M., Ha, D.M., Hutter, J.A., Stone, D.K., Pichler, M.R., Reynolds, A.D., Gendelman, H.E. and Mosley, R.L. Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases. J Neurochem. 2010 Sep 1;114(5):1261-76. PMCID: PMC2923270

Kraft-Terry, S., Gerena, Y., Wojna, V., Plaud-Valentin, M., Rodrigues, Y., Ciborowski, P., Mayo, R., Skolasky, R., Gendelman, H.E. Melendez, L.M. Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants. Proteomics Clin. Appl. 2010 Sep;4(8-9):706-14. PMC Journal – In Process

Kraft-Terry, S.D., Stothert, A.R., Buch, S., and Gendelman, H.E. HIV-1 Neuroimmunity in the Era of Antiretroviral Therapy. Neurobiology of Disease, 2010 Mar;37(3):542-8. PMCID: PMC2840259

Mosley, R.L. and Gendelman. H.E. Control of neuroinflammation as a therapeutic strategy for amyotrophic lateral sclerosis and other neurodegenerative disorders. Experimental Neurology. 2010 Mar;222(1):1-5. PMCID: PMC2824918

Nowacek, A., Zhang, G., McMillan, J., Kiyota, T., Batrakova, E., and Gendelman, H.E. Nanomedicine and neurodegenerative disorders. In press Nanomedicine in Health and Disease. Elsevier Press, New York, 2011.

Nowacek, A.S., Balkundi, S., McMillan, J., Roy, U., Martinez-Skinner, A., Mosley, R.L., Kanmogne, G., Kabanov, A.V., Bronich, T., Gendelman, H.E. Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages. J. Control Release. 2010 Nov 23. [Epub ahead of print]. PMC Journal – In Process

Nowacek, A.S., McMillan, J., Miller, R., Anderson, A., Rabinow B., and Gendelman, H.E. Nanoformulated Antiretroviral Drug Combinations Extend Drug Release and Antiretroviral Responses in HIV-1 Infected Macrophages: Implications for NeuroAIDS Therapeutics. J Neuroimmune Pharmacol. 5(4):592-60, 2010. PMCID: PMC Journal In Process

Reynolds, A.D., Stone, D.K., Hutter, J.A.L., Benner, E.J., Mosley, R.L., and Gendelman, H.E. Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson’s disease. J. Immunol. 2010 March 1;184(5):2261-71. PMCID: PMC2824790

Reinecke, J.B., Peng, H., Huang, Y., Chen, Q., Zheng, J. Neurogenesis, brain inflammation and its links to the pathogenesis and potential therapy of neurodegenerative disorders including HIV-1 Associated Neurocognitive Disorders. In. The Neurology of AIDS, 3rd Edition, Eds. H.E. Gendelman, I. P. Everall, H. Fox, H. Gelbard, I Grant, S. Lipton, S. Swindells. Springer, NY. In press 2011

Wiederin, J.L., Donahoe, R.M., Anderson, J.R., Yu, F., Fox, H.S., Gendelman, H.E., Ciborowski, P.S. Plasma proteomic analysis of simian immunodeficiency virus infection of rhesus macaques. J Proteome Res. 2010 Sep 3;9(9):4721-31. PMC Journal – In Process

2009

Beduneau A, Grotepas CB, Kabanov A, Rabinow BE, Gong N, Mosley RL, Boska MD, Dou H, and Gendelman HE. Facilitated monocyte-macrophage uptake and tissue distribution of immunoglobulin coated superparamagnetic iron-oxide nanoparticles. PLoS ONE, 4(2): e4343, 2009. PMCID: PMC2629545

Buescher JL, Martinez LB, Sato S, Okuyama S, Ikezu T. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. J Neuroimmune Pharmacol. 4:103-15, 2009. PMCID: PMC2680142

Ciborowski P. Biomarkers of HIV-1 Associated Neurocognitive Disorders: Challenges of Proteomic Approaches. Biomarkers in Medicine, 3(6):771-85, 2009.

Cui M, Huang Y, Zhao Y and Zheng J. (2009). New Insights for FOXO and Cell‑Fate Decision in HIV‑Infection and HIV Associated Neurocognitive Disorder. In: Forkhead Transcription Factors: Vital Elements in Biology and Medicine, edited by K. Maiese. ©2009 Landes Bioscience. (Review)

Dou H, Grotepas CB, McMillan JG, Destache CJ, Chaubal M, Werling J, Kipp J, Rainbow B, and Gendelman HE. Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS. J. Immunology, 183:661-669, 2009. PMCID: PMC2765254

Eggert D, Dash P, Gorantla S, Dou H, Schifitto G, Maggirwar SB, Dewhurst S, Poluektova L, Gelbard HA and Gendelman HE Neuroprotective Activities of CEP-1347 in Models of HIV-1 Encephalitis. J Immunol. 2010 184(2): 746–756. PMCID: PMC2805820

Eggert D, Dash PK, Serradji N, Dong CZ, Clayette P, Heymans F, Dou H, Gorantla S, Gelbard HA, Poluektova L, Gendelman HE. Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. J. Neuroimmunol 213:47-59, 2009. PMCID: PMC2757154

Erdmann N, Tian C, Huang Y, Zhao J, Herek S, Curthoys N, and Zheng J. In vitro Glutaminase Regulation and Mechanisms of Glutamate Generation in HIV-1 Infected Macrophage. J Neurochem. 109: 551-561, 2009. PMCID: PMC2668921

Huang Y, Walstrom A, Zhang L, Cui M, Ling Y, Zhao Y, and Zheng J. Type I Interferons and Interferon Regulatory Factors Regulate TNF-Related Apoptosis-Inducing Ligand (TRAIL) in HIV-1-Infected Macrophages. PLOS ONE. 4: e5397, 2009. PMCID: PMC2672636

Kadiu I Wang T, Schlautman JD, Dubrovsky L, Ciborowski P, Bukrinsky M, and Gendelman, HE. HIV-1 transforms the monocyte plasma membrane proteome. Cell Immunology 258:44-58, 2009. PMCID: PMC2746502

Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, beta-amyloidosis, and Learning Impairment of APP/PS1 Mice. Mol Ther 17:803-09, 2009. PMCID: PMC2709991

Kiyota T, Yamamoto M, Xiong H, Lambert M, Klein WL, Gendelman HE, Ransohoff R, and Ikezu T. CCL2 Accelerates Microglia-Mediated Aβ Oligomer Formation and Progression of Neurocognitive Dysfunction. PLoS One 4:e6197, 2009. PMCID: PMC2703798

Martinez LB, Walsh SM, Jacobsen MT, Sato S, Wiederin J, Ciborowski P, Ikezu T. Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. J Neuroimmune Pharmacol. Mar;4(1):116-28, 2009. PMCID: PMC2644346

Nowacek A, Gendelman HE. NanoART, neuroAIDS and CNS drug delivery. PMCID: PMC2727651

Nowacek A, Miller RL, McMillan J, Kanmogne G, Kanmogne M, Mosley RL, Ma Z, Graham S, Chaubal M, Werling J, Rabinow B, Dou H, Gendelman HE. NanoART Synthesis, Characterization, Uptake, Release, and Toxicology for Human Monocyte-Macrophage Drug Delivery. Nanomedicine 4(8): 903–917. 2009. PMCID: PMC2837804

Ramirez SH, Shongshan Fan S, Zhang M, Papugani A, Reichenbach N, Dykstra H, Mercer A, Tuma RF, and Persidsky Y. Inhibition of Glycogen Synthase Kinase 3β (GSK3β) Decreases Inflammatory Responses in Brain Endothelial Cells. Amer J Pathology 176(2): 881–892. PMCID: PMC2808093

Silberring J and Ciborowski P. Clinical proteomics – problem or challenge? Trends in Analytical Chemistry, 29(2): 128. 2009. PMCID: PMC2822390

Tian C, Murrin C, Zheng J. Mitochondrial fragmentation is involved in METH-induced cell death in rat hippocampal neural progenitor cells. PLOS ONE. 4: e5546, 2009. PMCID: PMC2677674

Uberti MG, Boska MD, Liu Y. A semi-automatic image segmentation method for extraction of brain volume from in vivo mouse head magnetic resonance imaging using Constraint Level Sets. J Neurosci Methods 179(2): 338-44, 2009. PMCID: PMC2718579

Whitney N, Eidem T, Peng H, Huang Y and Zheng J. Inflammation mediates varying effects in neurogenesis: Relevance to the pathogenesis of brain injury and neurodegenerative disorders. J Neurochem. 108: 1343-1359, 2009 (Review). PMCID: PMC2707502

Whitney N, Eidem T, Peng H, Huang Y, Zheng J. Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders. J. Neurochem. 108: 1343-59, 2009. PMCID: PMC2707502

Wu Y, Peng H, Cui M, Whitney NP, Huang Y, Zheng JC. CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway. J Neurochem. May;109(4):1157-67, 2009. PMCID: PMC2679099

2008

Chaudhuri, A., Yang, B., Gendelman, H.E., Persidsky, Y., Kanmogne, G.D. STAT1 signaling modulates HIV-1 induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. Blood. 111(4):2062-2072, 2008. PMCID: PMC2234049

Cui, M.,Huang, Y., Zhao, Y. and Zheng, J. Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages. J. Immunol. 180:898-906, 2008. PMCID: PMC2276663

Gendelman H.E., Ding S., Gong N., Liu J., Ramirez S.H., Persidsky Y., Lee Mosley R., Wang T, Volsky D.J., and Xiong H. Monocyte Chemotactic Protein-1 Regulates Voltage-Gated K(+) Channels and Macrophage Transmigration. J Neuroimmune Pharmacol. ;4(1):47-59, 2008. PMCID: PMC2657224

Gorantla, S., Liu, J., Wang, T., Holguin, A., Sneller, H.M., Dou, H., Kipnis, J., Poluektova, L., Gendelman, HE. Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis. Glia. 56(2):223-232; 2008. (PMID: 18046731; accepted 10/16/07)

Haorah J, Ramirez SH, Floreani N, Gorantla S, Morsey B, Persidsky Y. Mechanism of alcohol-induced oxidative stress and neuronal injury. Free Radic Biol Med. 2008 Dec 1;45(11):1542-50. PMCID: PMC2605399

Liu, Y., Uberti, M., Dou, H., Rabinow, B.E., Gendelman, H.E., and Boska, MD Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis. J. Neuroimmunol. 200(1-2):41-52, 2008. PMCID: PMC2572762

Liu, Y., Uberti, M., Mosley, R.L., Gendelman, H.E., and Boska, M. An Image Warping Technique for Rodent Brain MRI-Histology Registration Based On Thin-Plate Splines with Landmark Optimization. Proc. SPIE Med. Imaging, 2009. Not peer reviewed

Nowacek, A. and Gendelman, H.E. Nanotechnology and drug delivery for the nervous system and its relevance for neuroAIDS. Neuroimmunity. In press 2009. Not peer reviewed

Peng, H., Whitney, N., Wu, Y, Tian, T, Dou, H, Zhou, Y and Zheng, J. (2008). HIV-1-Infected and/or Immune-Activated Macrophage-Secreted TNF-a Affects Human Fetal Cortical Neural Progenitor Cell Proliferation and Differentiation.Glia. 56 (8): 903-16. PMCID: PMC2644639

Peng, H., Kolb, R., Kennedy, J. and Zheng, J. Differential expression of CXCL12 and CXCR4 during human fetal neural progenitor cell differentiation. J. Neuroimmunol Pharm 2007: 2:251-258. PMCID: PMC2169289

Potula R, Ramirez SH, Knipe B, Leibhart J, Schall K, Heilman D, Morsey B, Mercer A, Papugani A, Dou H, Persidsky Y. Peroxisome proliferator-activated receptor-gamma activation suppresses HIV-1 replication in an animal model of encephalitis. AIDS. 2008 Aug 20;22(13):1539-49. PMCID: PMC2688810

Ramirez S.H., Heilman D., Morsey B., Potula R., Haorah J., Persidsky Y.Activation of Peroxisome Proliferator-Activated Receptor gamma (PPARg) suppresses Rho GTPases in human brain microvascular

endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes. J. Immunol. 2008, 180:1854-1865. (PMID: 18209083; accepted 11/19/07)

Reynolds, A.D., Irena Kadiu, Sanjay K. Garg, Jason G. Glanzer, Tara Nordgen, Pawel Ciborowski, Ruma Banerjee, and Howard E. Gendelman. Nitrated alpha-synuclein and microglial neuroregulatory activities. J. Neuroimmune Pharm. 2008, 3(2): 59-74. PMCID: PMC2430927

Ricardo-Dukelow, M., Kadiu-Kielen, I., Wojciech, R., Schautman, J., Persidsky Y., Ciborowski, P., Kanmogne, G.D. and Gendelman, H.E. HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: New insights into blood-brain barrier dysfunction for HIV-1-associated dementia. J. Neuroimmunology 2007, 185: 37-46. PMCID: PMC2212599

Schlautman, J.D., Rozek, W., Stetler, R., Mosley, R, L. Gendelman, H.E. and Ciborowski, P. Multidimensional protein fractionation using ProteomeLab PF 2D™ for profiling amyotrophic lateral sclerosis immunity: A preliminary report. Proteome Science 2008, 6:26. PMCID: PMC2543004

Tian, C., Erdmann, N., Zhao, J., Cao, Z., Peng, H. and Zheng, J. (2008). HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase. J. Neurochem. 105: 994-1005. PMCID: PMC2614440

Uberti, M., Liu, Y., Dou, H., Mosley, R.L., Gendelman, H.E., and Boska, M. Registration of in vivo MR to histology of rodent brains using blockface imaging. Proc. SPIE Med. Imaging, 2009. Not peer reviewed

Wang, T., Gong, N., Liu, J., Kadiu, I., Kraft-Terry, S.D., Mosley, R.L., Volsky, D.J., Ciborowski, P., and Gendelman, H.E. Proteomic Modeling of HIV-1 infected microglia crosstalk. PLoS ONE, 3(6):e2507, 2008. PMCID: PMC2429966

Wang, T., Gong, N., Liu, J., Kadiu, I., Kraft-Terry, S.D., Schlautman, J.D., Ciborowski, P., Volsky, D.J., and Gendelman, H.E. HIV-1 infected astrocytes and the microglial proteome. J. Neuroimmune Pharmacol. (3):173-86, 2008. PMCID: PMC2579774

Whitney, N., Peng, H., Erdmann, N., Tian, T, Monaghan, D. and Zheng, J. Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 directs human neural progenitor cells differentiation to neurons. FASEB J. 22:2888-900, 2008. PMCID: PMC2493446

Xu J, Ikezu T. The Comorbidity of HIV-Associated Neurocognitive Disorders and Alzheimer's Disease: A Foreseeable Medical Challenge in Post-HAART Era. J Neuroimmune Pharmacol. 4(2):200-12, 2008.

Yamamoto M, Ramirez SH, Sato S, Cerny RL, Kaibuchi K, PersidskyY, Ikezu T. Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells. Amer. J. Pathol. 172: 521-533, 2008. PMCID: PMC2312373

Yamamoto, M., Kiyota, T., Walsh, S.M., Liu, J., Kipnis, J. and Ikezu T. Cytokine-Mediated Inhibition of Fibrillar Amyloid-β Peptide Degradation by Human Mononuclear Phagocytes. J. Immunology, 181: 3877-3886, 2008. PMCID: PMC2603577

Zheng, J., Huang, Y., Tang, K., Cui, M., Niemann, D., Lopez, A., Morgello, S. and Chen, S. HIV-1-Infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1beta and TNF-alpha: Involvement of mitogen-activated protein kinase and protein kinase R. J. Neuroimmunology 200: 100-110, 2008. PMCID: PMC2596956

Chapters in books:

Eggert, D., Anderson, E., Zheng, J., and Gendelman, H.E. Chemokines and the Neuropathogenesis of HIV-1 Infection. In The spectrum of Neuro-AIDS disorders pathophysiology, diagnosis, and treatment. Ed K. Goodkin ASM Press, Washington, D.C., 2008.

Erdmann, N., Huang, Y. and Zheng, J. The relevance of Chemokines and Cytokines to the pathogenesis of HIV-1 Associated Dementia. In NEURO-AIDS, eds by Paul Shapshak and Alireza Minagar, Nova Science Publisher, Inc., Hauppauge, NY.

Gendelman, H.E. and Ikezu T. Introducing neuroimmune pharmacology. In Neuroimmune Pharmacology. Eds: Ikezu, T. and Gendelman, H.E. Springer Science, New York, New York, 2008.

Gendelman, H.E. and Masliah, E. Innate and adaptive immunity in health and disease. In Neuroimmune Pharmacology. Eds: Ikezu, T. and Gendelman, H.E. Springer Science, New York, New York, 2008.

Ghorpade, A., Gendelman, H.E., and Kipnis, J. Macrophages, microglia, and dendritic cells. In Neuroimmune Pharmacology. Eds: Ikezu, T. and Gendelman, H.E. Springer Science, New York, New York, 2008.

Huang, Y., Erdmann, N., Hexum, T. and Zheng, J. The relevance of Chemokines, Cytokines and Growth factors to the pathogenesis of Neurodegenerative Disorders. In Neuroimmue Pharmacology. Eds by Tsuneya Ikezu and Howard E. Gendelman, Springer Publisher, Inc, NY, 2008.

Ikezu, T. and Gendelman, H.E. Neurobiology and neural systems. In Neuroimmune Pharmacology. Eds: Ikezu, T. and Gendelman, H.E. Springer Science, New York, New York, 2008.

Peng, H., Whitney, N.P., Tang, K., Toews, M. and Zheng, J. Stem cells and neurogenesis and its links to brain development and pathogenesis of neurodegenerative disorders. In Neuroimmue Pharmacology. Eds by Tsuneya Ikezu and Howard E. Gendelman, Springer Publisher, Inc, NY, 2008.

Reynolds, A., Kanmogne, G., Kadiu, I., and Gendelman, H.E. HIV and the Central Nervous System. In Comprehensive Textbook of AIDS Psychiatry, Neuropathologic Manifestations of HIV Infection. Eds. Cohen, M.A. and Gorman, J.M., 2008.