Rongshi Li, Ph.D.
Rongshi Li, Ph.D.


Chemistry and Medicinal Chemistry
Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 98198-6125
402-559-6609 (Office)
402-559-6521 (Lab)
402-559-5418 (Fax)

Teaching Activities:

Medicinal Chemistry I PHSC 626 (Course Coordinator)
Pharmaceutical Biotechnology PHSC 520 (Course Coordinator)
Advanced Medicinal Chemistry PHSC 830
Pharmaceutical Chemistry PHSC 852
Medicinal Chemistry II PHSC 628
Pharmaceutical Sciences Applications in Pharmacy PHSC 691

Research Activities/Interests:

Fragment-based and structure-guided design of enzyme inhibitors and disruptors of protein-protein interactions; synthesis of natural products and their derivatives for drug discovery; hit-to-lead and lead optimization using organic/medicinal chemistry; drug design and development in anticancer and antibiotic therapeutics.

Recent Publications:

  1. Li, R.* Marinopyrroles: Unique Drug Discoveries Based on Marine Natural Products. Med. Res. Rev. 2016, 36, 169-189. 10.1002/med.21359.
  2. Feng, Y.; LoGrasso, P.V.; Defert, O.; Li, R.* Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential. J. Med. Chem. 2016, 59, 2269-2300.
  3. Yang, Z.; Liu, Y.; Ahn, J.; Qiao, Z.; Endres, J.L.; Gautam, N.; Huang, Y.; Li, J.; Zheng, J.; Alnouti, Y.; Bayles, K.W.; Li, R.* Novel fluorinated pyrrolomycins as anti-staphylococcal biofilm agents: Design, synthesis, pharmacokinetics and antibacterial activities. Eur. J. Med. Chem. 2016, 124, 129–137.
  4. Smith, E.W.; Nevins, A.M.; Qiao, Z.; Liu, Y.; Getschman, A.E.; Vankayala, S.L.; Kemp, M.T.; Peterson, F.C.; Li, R.; Volkman, B.F.; Chen, Y. Structure-based identification of novel ligands targeting multiple sites within a chemokine-G-protein-coupled receptor interface. J. Med. Chem. 2016, 59, 4342–4351.
  5. Li, R.*; Cheng, C.; Balasis, M.E.; Liu, Y.; Garner, T.P.; Daniel, K.G.; Li, J.; Qin, Y.; Gavathiotis, E.; Sebti, S.M. Design, Synthesis and Evaluation of Marinopyrrole Derivatives as Selective Inhibitors of Mcl-1 Binding to Pro-apoptotic Bim and Dual Mcl-1/Bcl-xL Inhibitors. Eur. J. Med. Chem. 2015, 90, 315–331.
  6. Smith, E.W.; Liu, Y.; Getschman, A.E.; Peterson, F.C.; Ziarek, J.J.; Li, R.*; Volkman, B.F.; Chen, Y. Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine. J. Med. Chem. 2014, 57, 9693-9699. 
  7. Liu, Y.; Haste, N.M.; Thienphrapa, W.; Li, J.; Nizet, V.; Hensler, M.; Li, R.* Marinopyrrole Derivatives as Potential Antibiotic Agents against Methicillin-Resistant Staphylococcus aureus (III). Mar. Drugs 2014, 12, 2458–2470. PMID: 24796304.
  8. Ziarek, J.J.; Liu, Y.; Smith, E.; Zhang, G.; Peterson, F.C.; Chen, J.; Yu, Y.; Chen, Y. Volkman, B.F.; Li, R.* Fragment-based Optimization of Small Molecule CXCL12 Inhibitors for Antagonizing the CXCL12/CXCR4 Interaction. Curr. Top. Med. Chem. 2012, 12, 2727–2740. PMID: 23368099.
  9. Li, R.*; Martin, M.P.; Liu, Y.; Wang, B.; Patel, R.A.; Sun, N.; Pireddu, R.; Lawrence, N.J.; Li, J.; Haura, E.B.; Sung, S.S.; Guida, W.C.; Schonbrunn, E.; Sebti, S.M. Fragment-based and Structure-guided Discovery and Optimization of Rho Kinase Inhibitors. J. Med. Chem. 2012, 55, 2474–2478. PMID: 22272748.
  10. Li, R.*; Pourpak, A.; Morris, S.W. Inhibition of the Insulin-like Growth Factor-1 Receptor (IGF1R) Tyrosine Kinase as a Novel Cancer Therapy Approach. J. Med. Chem. 2009, 52, 4981–5004. (One of 10 Most-Accessed Articles, July-Sept. 2009). PMID: 19610618.