Rongshi Li, PhD

Rongshi Li, PhD

Professor

Chemistry and Medicinal Chemistry
Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 98198-6125
402-559-6609 (Office)
402-559-6521 (Lab)
402-559-5418 (Fax)
Email

Teaching Activities:

Medicinal Chemistry I PHSC 626 (Course Coordinator)
Pharmaceutical Biotechnology PHSC 520 (Course Coordinator)
Advanced Medicinal Chemistry PHSC 830
Pharmaceutical Chemistry PHSC 852
Medicinal Chemistry II PHSC 628
Pharmaceutical Sciences Applications in Pharmacy PHSC 691

Research Activities/Interests:

Fragment-based and structure-guided design of enzyme inhibitors and disruptors of protein-protein interactions; synthesis of natural products and their derivatives for drug discovery; hit-to-lead and lead optimization using organic/medicinal chemistry; drug design and development in anticancer and antibiotic therapeutics.

Recent Publications:

  1. McGuire, T.R.; Coulter, D.W.; Bai, D.; Sughroue, J.A.; Li, J.; Yang, Z.; Qiao, Z.; Liu, Y.; Murry, D.J.; Chhonker, Y.S.; McIntyre, E.M.; Alexander, G.; Sharp, J.G.; Li, R.* Mechanism of action of MP1 plus temisirolimus in MYCN Amplified Chemoresistant Neuroblastoma Cell Line. BMC Cancer, 2019, 19, 837. PMID: 31455317
  2. Bernatchez, J.A.; Yang, Z.; Coste, M.; Li, J.; Beck, S.; Liu, Y.; Clark, A.E.; Zhu, Z.; Luna, L.A.; Sohl, C.; Purse, B.W., Li, R.*; Siqueira-Neto, J.L. Development and validation of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting Zika virus. Antimicrob. Agents Chemother. 2018, 62, e00725-18/1–e00725-18/11. PMID: 30061280.
  3. Li, R.* Marinopyrroles: Unique Drug Discoveries Based on Marine Natural Products. Med. Res. Rev. 2016, 36, 169–189. Published online, August 31, 2015, DOI:10.1002/med.21359. PMID: 26332654.
  4. Feng, Y.; LoGrasso, P.V.; Defert, O.; Li, R.* Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential. J. Med. Chem. 2016, 59, 2269–2300. PMID: 26486225.
  5. Smith, E.W.; Nevins, A.M.; Qiao, Z.; Liu, Y.; Getschman, A.E.; Vankayala, S.L.; Kemp, MT; Peterson, F.C.; Li, R.*; Volkman, B.F.; Chen, Y. Structure-based identification of novel ligands targeting multiple sites within a chemokine-G-protein-coupled receptor interface. J. Med. Chem. 2016, 59, 4342–4351. PMID: 27058821.
  6. Li, R.*; Cheng, C.; Balasis, M.E.; Liu, Y.; Garner, T.P.; Daniel, K.G.; Li, J.; Qin, Y.; Gavathiotis, E.; Sebti, S.M. Design, Synthesis and Evaluation of Marinopyrrole Derivatives as Selective Inhibitors of Mcl-1 Binding to Pro-apoptotic Bim and Dual Mcl-1/Bcl-xL Inhibitors. Eur. J. Med. Chem. 2015, 90, 315–331. PMID: 25437618.
  7. Smith, E.W.; Liu, Y.; Getschman, A.E.; Peterson, F.C.; Ziarek, J.J.; Li, R.;* Volkman, B.F.; Chen, Y. Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine. J. Med. Chem. 2014, 57, 9693–9699. PMID: 25356720.
  8. Patel, R.A.; Liu, Y.; Wang, B.; Li, R.; Sebti, S.M. Identification of Novel ROCK Inhibitors with Anti-migratory and Anti-invasive Activities. Oncogene, 2014, 33, 550–555 (a featured article on www.MDLinx.com). PMID: 23396364.
  9. Li, R.*; Martin, M.P.; Liu, Y.; Wang, B.; Patel, R.A.; Sun, N.; Pireddu, R.; Lawrence, N.J.; Li, J.; Haura, E.B.; Sung, S.S.; Guida, W.C.; Schonbrunn, E.; Sebti, S.M. Fragment-based and Structure-guided Discovery and Optimization of Rho Kinase Inhibitors. J. Med. Chem. 2012, 55, 2474–2478. PMID: 22272748.
  10. Li, R.*; Morris, S.W. Development of Anaplastic Lymphoma Kinase (ALK) Small-Molecule Inhibitors for Cancer Therapy. Med. Res. Rev. 2008, 28, 372–412. PMID: 17694547.