Xin Wei, PhD


Research Assistant Professor

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986125 Nebraska Medical Center
Omaha, NE 68198-6125
402-559-5643 (Fax)


Teaching Activities:
Dr. Wei is currently assisting Dr. Dong Wang in Pharmaceutical Chemistry for Drug Delivery and Nanomedicine (PHSC 852)

Research Activities/Interests:
Dr. Wei has experience in evaluating different pharmaceutical formulations’ efficacy and safety in the  animal models. Her research interests focused on the development of drug delivery system for the treatment of inflammatory diseases, musculoskeletal disorders, and improve the health of women and children.

Recent Publications:

  1. Gang Zhao*, Rongguo Ren*, Xin Wei*, Zhenshan Jia, Ningrong Chen, Yuanyuan Sun, Zhifeng, Zhao, Haizhen Zhong, Subodh Lele, Mary Goldring, Steven Goldring, Dong Wang. Thermoresponsive Polymeric Dexamethasone Prodrug for Arthritis Pain (Journal of Controlled Release,(2021))
  2. Ningrong Chen, Rongguo Ren, Xin Wei, Roshni Mukundan, Guojuan Li, Xiaoke Xu, Gang Zhao, Zhifeng Zhao, Subodh Lele, Richard Reinhardt, Dong Wang. Thermoresponsive Hydrogel-based Local Delivery of Simvastatin for the Treatment of Periodontitis. (Molecular Pharmaceutics (2021))
  3. Yosif Almoshariab*, Rongguo Ren*, Haipeng Zhang, Zhenshan Jia, Xin Wei, Ningrong Chen, Guojuan Li, Sangjin Ryu, Subodh M. Lele, Richard A.Reinhardt, DongWang. GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis. (Biomaterials 261 (2020): 120293.)
  4. Zhifeng Zhao, Zhenshan Jia, Kirk W Foster, Xin Wei, Fangfang Qiao, Haochen Jiang, Yan Jin, Guojuan Li, Ningrong Chen, Gang Zhao, Geoffrey M Thiele, Jennifer L Medlin, James R O’Dell, Dong Wang. Dexamethasone prodrug nanomedicine (ZSJ-0228) treatment significantly reduces lupus nephritis in mice without measurable side effects—A 5-month study. (Nanomedicine: Nanotechnology, Biology and Medicine 31 (2020): 102302.)
  5. Zhenshan Jia*, Gang Zhao*, Xin Wei&, Dexuan Kong, Yuanyuan Sun, You Zhou, Subodh M. Lele, Edward V. Fehringer, Kevin L. Garvin, Steven R. Goldring, and Dong Wang&. Structural optimization of HPMA copolymer-based dexamethasone prodrug for improved treatment of inflammatory arthritis. (Jounral of Controlled Release DOI:10.1016/j.jconrel.2020.05.028).
  6. Xin Wei*, Gang Zhao*, Xiaobei Wang, Nagsen Gautam, Zhenshan Jia, Zhifeng Zhao, Dexuan Kong, Fan Zhang, Sushil Kumar, Yuanyuan Sun, Ningrong Chen, Xiaoyan Wang, Libin Yang, Rongguo Ren, Geoffrey M Thiele, Tatiana K Bronich, James R O'Dell, and Dong Wang. Head-to-head Comparative Pharmacokinetic and Biodistribution (PK/BD) Study of Two Dexamethasone Prodrug Nanomedicines on Lupus-prone NZB/W F1 Mice. (Nanotechnology, Biology and Medicine 29 (2020): 102266.).
  7. Gang Zhao*, Xin Wei*, Jianbo Wu, Derrick D Eichele, Subodh M Lele, Libin Yang, Fan Zhang, Dong Wang. A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice (Pharmaceutical Research4 (2019): 64.)
  8. Laura Weber, Xiaobei Wang, Rongguo Ren, Xin Wei, Gang Zhao, Junxiao Yang, Hongjiang Yuan, Huiling Pang, Hanjun Wang, Dong Wang, The Development of a Macromolecular Analgesic for Arthritic Pain. (Molecular Pharmaceutics. 2019)
  9. Zhenshan Jia*, Xiaobei Wang1*, Xin Wei, Gang Zhao, Kirk W. Foster, Nagsen Gautam, Fang Yu, Fang Yuan, Yangyang Gao, Yazen Alnouti, Geoffrey M. Thiele, Tatiana K. Bronich, James R. O’Dell and Dong Wang. Micelle-Forming Dexamethasone Prodrug Attenuates Nephritis in Lupus-Prone Mice without Apparent Glucocorticoid Side Effects. (ACS Nano, doi: 10.1021/acsnano.8b01249. 2018.)
  10. Xin Wei*, Jianbo Wu*, Gang Zhao, Josselyn Galdamez, Subodh M. Lele, Xiaoyan Wang, Yanzhi Liu, Dhruvkumar M. Soni, P. Edward Purdue, Ted R. Mikuls, Steven R. Goldring, Dong Wang. Development of a Janus Kinase inhibitor prodrug for the treatment of rheumatoid arthritis. Molecular Pharmaceutics. (Molecular Pharmaceutics, DOI: 10.1021/acs.molpharmaceut.8b00433. 2018.)