PSGP Curriculum

The Pharmaceutical Sciences Graduate Program (PSGP) is intended for those who wish to pursue a vigorous program of study leading to M.S., Ph.D., or a combined M.D./Ph.D. degree. The PSGP curriculum consists of a core of 3+1 required courses and a minimum of 2 elective courses from the list below. The need for any additional courses beyond the six-course curriculum will be determined by the student advisory committee.

In addition to the required 6 courses, all PSGP students are required to register for seminar (PHSC 970) and journal club (PHSC 960) during the Fall and Spring semesters.

Required Courses (select all 3)

PHSC 845. Quantitative Pharmaceutical Analysis

A lecture and laboratory course covering the theory and applications of current analytical methods for the quantitative determination of drugs, metabolites, and other biologically active agents.

3 credit hours / Prerequisite: first year organic chemistry and permission of instructor

Coordinator: Dr. Marky

Offered: Every Fall

PHSC 885. Physical Pharmacy

A study of physicochemical principles applicable to drug delivery systems, with emphasis on solubility, diffusion, dispersed systems, and stability testing.

3 credit hours / Prerequisite: Permission of instructor

Coordinator: Dr. Vetro

Offered: Every Spring

PHSC 852. Pharmaceutical Chemistry

This course will review various chemical reactions and their applications in prodrug design, pharmaceutical formulation, drug delivery and nanomedicine. Practical/laboratory experiments will be included.

3 credit hours / Prerequisite: PHSC 845

Coordinator: Dr. Wang

Offered: Every Spring

Required IPBS Course (select 1)

IPBS 801- Fundamentals of Biomolecules

Introduction to concepts in the biochemistry of macromolecules, including the structure and function of proteins and nucleic acids, sugars and lipids. Basic material related to acid-base, buffers, intermolecular interactions, and enzymology lead to discussion of synthesis, folding, and degradation of proteins. Basic information on the structure of DNA and RNA leads to discussion of the mechanisms of replication, repair, recombination, restriction, transcription-translation and regulation of chromatin structure/gene expression.

3 credit hours / Prerequisite: Permission of instructor.

Offered: Every Fall

IPBS 802 - Molecular Cell Biology

This course provides and introduction to fundamental concepts of cell structure, cell division and death, and the mechanisms of cellular transport/trafficking, communication, and adhesion.

3 credit hours / Prerequisite: Permission of instructor.

Offered: Every Fall

Elective Courses (select 2)

PHSC 820. Selected Topics in Pharmaceutical Sciences

1-2 credit hours - A detailed study of specific subject areas related to the pharmaceutical sciences. Evaluation and discussion of the scientific literature is an integral part of the course. Prereq: Permission of instructor. Offered: Every semester. Instructor: Advisor

PHSC 821. Organic Chemistry and Applications to Biomolecules

2 credit hours - This course deals with the basic principles to understand the structure, reactivity, and synthesis of bioactive organic molecules. Prereq: Permission of Instructor. Offered: Even years. Instructor: Dr. Dong

PHSC 825. Ophthalmic Drug Discovery

3 credit hours even yrs. This course will survey ocular diseases, their pathogenesis, current drug treatment, and approaches to the development of drug treatment. Special methods for the evaluation of ocular drugs as well as use of animal models will be included. Prereq: Biochemistry, Permission of Instructor. Offered: Varies. Instructor: Dr. Kador

PHSC 830. Advanced Medicinal Chemistry

3 credit hours odd yrs. This course will apply essential concepts of medicinal chemistry at an advanced level. Receptor theory, stereochemistry, chemical bonding, and bioisosterism will be discussed as they relate to drug design. Prereq: PHSC 626 or equivalent. Offered: Odd years. Instructor: Dr. Vennerstrom 

PHSC 843. Spectroscopic Organic Structural Analysis

3 credit hours even yrs. This course deals with a theoretical and practical understanding of UV, IR, NMR and MS applied to organic structural elucidation. The advantages, disadvantages, limitations, and appropriate use of each spectroscopic technique will be described. Prereq: First year organic chemistry. Offered: Varies. Instructor: Dr. Vennerstrom 

PHSC 848. Nanoimaging and Bioimaging

3 credit hours odd yrs. This course will review various nanotechnology approaches to imaging, probing, and manipulation at the nanoscale and discuss significance and impact of these technological advances on pharmaceutical and biomedical industries. Prerequisites: Undergraduate level of Biophysical Chemistry, Permission of Instructor. Offered: Odd years. Instructor: Dr. Lyubchenko.

PHSC 851. Innovative Drug Delivery Systems

3 credit hours odd yrs. This course will examine the innovations in the design, preparation, and evaluation of modern drug delivery systems. Prereq: permission of instructor. Offered: Even years. Instructor: Dr. Wang 

PHSC 861. Advanced Pharmacokinetics and Pharmacodynamics

3 credit hours even yrs. The mathematical description of the rate and extent of drug absorption, distribution, elimination and action. Prereq: PHSC 674 or permission of instructor. Offered: Varies. Instructor: Dr. Alnouti

PHSC 880. Principles and Methodologies in Cancer Research

3 credit hours (cross-listed with BIOC 880, CRGP 880, PAMM 880, PHAR 880). A survey of the biology and biochemical mechanisms underlying cancer development, prevention, and therapy. Prereq: BRTP 821, 822, or equivalent, or permission of instructor.

PHSC 890. Polymer Therapeutics

3 credit hours even yrs. A study of the physicochemical and biomedical properties of synthetic polymers with an emphasis on their application as modern therapeutics. Prereq: permission of instructor. Offered: Varies. Instructor: Dr. Oupicky

PHSC 902. Drug Delivery and Nanomedicine Research

3 credits hours. This is a webcast seminar course based on the lectures presented by outside and internal Faculty speakers in the seminar program of the Center of Drug Delivery and Nanomedicine (CDDN). Videos of these seminars are posted online. Offered: Fall semester. Instructor: Dr. Bronich

PHSC 904. Delivery and Biocompatibility of Protein and Nucleic Acid Drugs

3 credits hours. This course is designed to teach students about the delivery and biocompatibility of proteins, peptides and nucleic acid drugs and dosage form design. Topics include biocompatibility, protein and peptide drug delivery, nucleic acid drug delivery, and oligonucleotides, siRNA, shRNA, miRNA and gene therapy. Offered: Spring semester. Instructor: Dr. Mahato

PHSC 910 Pharmacokinetics and Biopharmaceutics

3 cr. Spring, annually. This course will address in depth the drug- and body- biopharmaceutical factors that control the absorption, distribution, metabolism, and excretion (ADME) of therapeutic molecules and how they affect the overall pharmacokinetic (PK) profile of these molecules. It will also address the theory and applications of pharmacokinetics in drug discovery and development and its relationship to pharmacodynamics (PD) and toxicity (Tox).

PHSC 921. Biophysical Chemistry

3 credit hours even yrs. The course will cover the biophysical chemistry of nucleic acids and proteins including the study of these molecules using NMR, calorimetry, and fluorescence. Prereq: Permission of instructor. Offered: Even years. Instructor: Dr. Marky

PHSC 950. Advanced Toxicology

3 credit hours odd yrs. This course deals with the adverse effects of chemicals on biological systems. Physiological and biochemical mechanisms of toxicity at the cellular and subcellular levels will be emphasized. Prereq: Permission of instructor. Offered: Odd years. Instructor: Dr. J. McMillan

IPBS 803 - Fundamentals of Receptors & Cell Signaling

Introduction to fundamental concepts of how receptors regulate cell function through signal transduction networks.

Offered: Fall, annually

BIOS 806. Biostatistics I

This course is designed to prepare the graduate student to understand and apply biostatistical methods needed in the design and analysis of biomedical and public health investigations. The major topics to be covered include types of data, descriptive statistics and plots, theoretical distributions, probability, estimation, hypothesis testing, and one-way analysis of variance. A brief introduction to correlation and univariate linear regression will also be given. The course is intended for graduate students and health professionals interested in the design and analysis of biomedical or public health studies.

University of Nebraska, Omaha

CHEM 8246 Advanced Organic Chemistry (Mechanisms)

CHEM 8236 Advanced Organic Chemistry (Synthesis)

MATH 8005 Statistical Methods I

MATH 8015 Statistical Methods II