Goutam Mondal, Ph.D.

Goutam Mondal, Ph.D.Postdoctoral Research Associate

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
985965 Nebraska Medical Center
Omaha, NE 68198-5965
(402) 559-6987
Email

Education

2012 - Ph.D. Chemical Biology (Specialization: Liposomal drugs/gene delivery). Osmania University, Hyderabad, India.
2005 - M.S. Organic Chemistry, University of Calcutta, Calcutta, India
2003 - B.S. Chemistry, University of Calcutta, Calcutta, India

Research Interests

Developments of novel receptor targeted polymeric nanocarriers for delivery of therapeutic agents (chemotherapeutic drugs, anti-fibrotic drugs and miRNAs) for treatment of cancers (pancreatic and prostate) and liver fibrosis.

Publications

  1. Coadministration of Polymeric Conjugates of Docetaxel and Cyclopamine synergistically inhibits Orthotopic Pancreatic Cancer Growth and Metastasis. Saud A. Almawash, Goutam Mondal, Ram I. Mahato. Pharm Res. Just Accepted

  2. EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine and miRNA-205 for treatment of advanced pancreatic cancer. Mondal G, Almawash S, Mahato RI. Mol Pharm. 2017 Sep 5;14(9):3121-3133.

  3. Chemosensitization and Inhibition of Pancreatic Cancer Stem Cells Proliferation by Upregulation of microRNA-205. Amit K Chaudhary, Goutam Mondal, Virender Kumar, Krishna Kattel, and Ram I Mahato. Cancer Lett. 2017 Aug 28; 402:1-8

  4. Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer. Vinod Kumar, Amit Chaudhary, Yuxiang Dong, HA Zhong, Goutam Mondal, Feng Lin, Virender Kumar, and Ram Mahato. Sci Rep. 2017 May 10;7(1):1665

  5. Polymer conjugate of a microtubule destabilizer inhibits lung metastatic melanoma. Yang R, Mondal G, Ness RA, Arnst K, Mundra V, Miller DD, Li W, Mahato RI. J Control Release. 2017 Jan 24; 249:32-41. doi: 10.1016/j.jconrel.2017.01.028.

  6. Biodistribution of Self-Assembling Polymer-Gemcitabine Conjugate after Systemic Administration into Orthotopic Pancreatic Tumor bearing Mice. Kattel K, Mondal G, Lin F, Kumar V, Mahato RI. Mol Pharm. 2016 Oct 31.

  7. Combination Therapy of Paclitaxel and Cyclopamine Polymer-Drug Conjugates to Treat Advanced Prostate Cancer. Yang R, Mondal G, Wen D, Mahato RI. Nanomedicine. 2016 pii: S1549-9634(16)30107-1. doi: 10.1016/j.nano.2016.07.017.

  8. EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer. Mondal G, Kumar V, Shukla SK, Singh PK, Mahato RI. Biomacromolecules. 2016, 17(1), 301-313.

  9. Co-delivery of small molecule hedgehog inhibitor and miRNA for treating liver fibrosis. Kumar V, Mondal G, Dutta R, Mahato RI. Biomaterials. 2016, 76, 144-156.

  10. Impact of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir in patients with pancreatic cancer. Kattel K, Evande R, Tan C, Mondal G, Grem JL, Mahato RI. Br J Clin Pharmacol. 2015, 80(2), 267-275.

Honors and Awards