Merry L. Lindsey

Stokes-Shackleford Professor and Chairlindsy photo
PhD 1999, Baylor College of Medicine
Specialty: Cardiovascular sciences
Major Interest: Myocardial infarction-induced cardiac wound healing

Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of cardiac wound healing responses that involve both the stimulation of robust inflammation to clear necrotic myocytes and tissue debris and the induction of extracellular matrix (ECM) protein synthesis to generate an infarct scar. Collectively, this process in known as LV remodeling. Matrix metalloproteinase-9 (MMP-9) is a key regulator of LV remodeling after MI, through direct effects on ECM turnover as well as indirect effects on the regulation of the major cell types that coordinate cardiac wound healing- namely the infiltrating leukocytes and the cardiac fibroblasts. Our laboratory has expanded the understanding of MMP-directed MI LV remodeling, including recent proteomic advances focused on the ECM compartment to provide novel physiological and translational insights. Cardiac ECM research has evolved over the last decade, and exciting new research in the lab is providing further insight into MMP directed cardiac ECM turnover in the LV after MI.

Lindsey Chart
MMP-9 roles in cardiac remodeling after myocardial infarction. The matrix metalloproteinase 9 (MMP-9) MI knowledge map includes factors that stimulate production and secretion of MMP-9, factors that stimulate or inhibit its activation, substrates that are processed by MMP-9, and how cellular and left ventricular physiology are altered. From Lindsey ML, Nat Rev Cardiol. 2018 Aug;15(8):471-479.

Link to Publications