Executive Associate Dean, UNMC Graduate Studies
Ph.D. 1982, Indiana University
Specialty: Renal Physiology
Major Interest: Renal complications of type 1 diabetes; Contractile signaling in renal microvascular smooth muscle
Much of our research has focused on the causes and consequences of renal oxidative stress during type 1 diabetes (T1D) in rodents, revealing a role for oxidative stress in evoking T1D-induced renal arteriolar vasodilation (arising via effects on inward-rectifier K channels and calcium homeostasis) and accelerated sodium transport by the thick ascending limb (resulting from protein kinase C-mediated NADPH oxidase activation). Our work has implicated mitochondria as one source of renal reactive oxygen species during the early stage of T1D, a phenomenon associated with tyrosine nitration of key mitochondrial enzymes. Our recent efforts have unveiled a complex interplay between the full-length estrogen receptor α and its splice variants in modulating renal interstitial macrophage infiltration, glomerular hyperfiltration, glomerular enlargement and proteinuria during T1D. Working with our collaborators at the University of Alabama at Birmingham, we are also exploring the endothelin-dependent underpinnings of endoplasmic reticulum (ER) stress in the kidney. This work may lay the groundwork for developing novel therapeutic approaches to prevent the onset of renal injury and progression to chronic renal diseases.
Dr. Carmines’ leadership role in Graduate Studies focuses primarily on academic affairs, ranging from coordinating program reviews to resolving student/mentor issues. She also has been heavily involved in the leading design team for Seguidor™ (UNMC’s Graduate and Postdoctoral Student Information System), providing career services and professional skills training for graduate students, and organizing the semi-annual Dissertation Boot Camp.
- Irsik DL, Romero-Aleshire MJ, Chavez EM, Fallet RW, Brooks HL, Carmines PK, Lane PH. Renoprotective impact of estrogen receptor α and its splice variants in female mice with type 1 diabetes. Am J Physiol Renal Physiol. 2018 Apr 18; doi: 10.1152/ajprenal.00231.2017. [Epub ahead of print] PMID: 29667912
- De Miguel C, Hamrick WC, Hobbs JL, Pollock DM, Carmines PK, Pollock JS. Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidney. Sci Rep. 2017 Feb 23; 7:43152. doi:10.1038/srep43152. PMID:28230089
- Saleh MA, De Miguel C, Stevens DI, Carmines PK, Pollock DM, Pollock JS. Free radical scavenging decreases endothelin-1 excretion and glomerular albumin permeability during type 1 diabetes. Physiol Rep. 2016 Dec; 4(24). pii: e13055. doi:10.14814/phy2.13055. PMID:28039404
- Carmines PK. Mechanisms of altered renal microvascular function in type 1 diabetes: potential contribution to end organ damage. Curr Vasc Pharmacol. 2014;12(6):781-7. PMID:24066931
- Irsik D.L., Carmines PK., Lane P.H. Classical estrogen receptors and ERα splice variants in the mouse. PLoS One. 2013 Aug 5; 8(8):e70926. doi:10.1371/journal.pone.0070926. PMID:23940668