Huaqing Li

Huaqing LiInstructor
Ph.D. 2006, Chinese Academy of Sciences
Specialty: Physical electronics
Major Interest: Biosensor, Instrumentation, Signal Sampling and Processing
Curriculum Vitae

Maintaining a right concentration range in plasma is very important for the proper functioning of our heart, muscles and nerves. Research in the laboratory is focused on fully understanding the mechanisms behind how the kidneys regulate K balance when there is a high K dietary intake or an unexpected elevation. Our laboratory has identified two types of potassium channels (BK-α/β1 and BK-α/β4) that are able to handle a high K diet. While using traditional in-vitro tools such as AAS, HPLC, patch-clamp, and in-vivo micro-puncture technique to determine the role of the potassium channels during Na-independent K excretion, we are attempting to develop novel analytical technology such as biosensors and tubule-on-a-chip. The development of the biosensor would enable long-term, real-time monitoring of a range of variables that are relevant to function of the potassium channels. My main focus is to study the state-of-the-art technologies to advance the biosensing technique, providing powerful tools for physiologists to study the kidney function in-vivo/vitro. My research endeavors on biosensor development will span many disciplines including analytical chemistry, nanotechnology, surface chemistry, material science, biotechnology, device physicals, and electrical engineering.

Biosensor Development

Recent publications:
  1. Wang B, Wen D, Li H, Wang-France J, Sansom SC.  Net K+ secretion in the thick ascending limb of mice on a low-Na, high-K diet.  Kidney Int. 2017 Jul 6. pii: S0085-2538(17)30281-8. PMID: 28688582
  2. Wen, D, Yuan, Y, Cornelius, RJ, Li, H, Warner, PC, Wang, B, Wang-France, J, Boettger, T and Sansom, SC. Deficient acid handling with distal RTA in the NBCe2 knockout mouse. AJP: Renal 2015. 309 (6) 523-530 PMID:26109087
  3. Wen, D, Yuan, Y, Warner, PC, Wang, B, Cornelius, RJ, Wang-France, J, Li, H, Boettger, T, and Sansom, SC.  Increased ENaC activity contributes to hypertension caused by NBCe2 deficiency. Hypertension. 2015. 66 (1) 68-74. PMID:25941340
  4. Cornelius, RJ, Wen, D, Li, H, Yuan, Y, Wang-France, J, Warner, PC and Sansom, SC. Low Na, high K diet and the role of aldosterone in BK-mediated K excretion. PLoS One. 2015 10 (1) e0115515. PMID:25607984
  5. Wen, D, Cornelius, RJ, Rivero-Hernandez, D, Yuan, Y, Li, H, Weinstein, AM and Sansom, SC. Relation between BK-a/b4-mediated K secretion and ENaC-mediated Na reabsorption. Kidney International. 2014, 86: 139-145. PMID:24573316