Ph.D. 2006, Chinese Academy of Sciences
Specialty: Physical electronics
Major Interest: Biosensor, Instrumentation, Signal Sampling and Processing
Maintaining a right concentration range in plasma is very important for the proper functioning of our heart, muscles and nerves. Research in the laboratory is focused on fully understanding the mechanisms behind how the kidneys regulate K balance when there is a high K dietary intake or an unexpected elevation. Our laboratory has identified two types of potassium channels (BK-α/β1 and BK-α/β4) that are able to handle a high K diet. While using traditional in-vitro tools such as AAS, HPLC, patch-clamp, and in-vivo micro-puncture technique to determine the role of the potassium channels during Na-independent K excretion, we are attempting to develop novel analytical technology such as biosensors and tubule-on-a-chip. The development of the biosensor would enable long-term, real-time monitoring of a range of variables that are relevant to function of the potassium channels. My main focus is to study the state-of-the-art technologies to advance the biosensing technique, providing powerful tools for physiologists to study the kidney function in-vivo/vitro. My research endeavors on biosensor development will span many disciplines including analytical chemistry, nanotechnology, surface chemistry, material science, biotechnology, device physicals, and electrical engineering.
- Wen D, Yuan Y, Cornelius RJ, Li H, Warner PC, Wang B, Wang-France J, Boettger T, Sansom SC. Deficient acid handling with distal RTA in the NBCe2 knockout mouse. Am J Physiol Renal Physiol. 2015 Sep 15; 309(6):F523-30. PMID: 26109087
- Wen D, Yuan Y, Warner PC, Wang B, Cornelius RJ, Wang-France J, Li H, Boettger T, Sansom SC. Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency. Hypertension. 2015 Jul; 66(1):68-74. PMID: 25941340
- Cornelius RJ, Wen D, Li H, Yuan Y, Wang-France J, Warner PC, Sansom SC. Low Na, high K diet and the role of aldosterone in BK-mediated K excretion. PLoS One. 2015 Jan 21; 10(1):e0115515. PMID: 25607984
- Wen D., Cornelius. R. J, Rivero-Hernandez D., Yuan Y., Li H., Weinstein A. M, Sansom S. C. Relation between BK-α/β4-mediated potassium secretion and ENaC-mediated sodium reabsorption. Kidney Int. 86, 139-45. 2014. PMID: 24573316
- Li, H., Martha, S. K., Unocic, R. R., Luo, H., Dai, S., and Qu, J. High Cyclability of Ionic Liquid-Produced TiO2 Nanotube Arrays as an Anode Material for Lithium-Ion Batteries, Journal of Power Sources. 218,88–92. 2012.