Yulong Li

Yulong LiProfessor                                                                     
M.D. 1984, Hebei Medical University Ph.D. 1994, Hebei Medical University
Specialty: Cardiovascular-, Muscle-, and Neuro-Physiology
Major Interest: Regulatory role of the peripheral nervous system in peripheral tissues (such as skeletal muscle and myocardium) in heart failure, diabetes, and ischemia-reperfusion
Curriculum Vitae

The goal of research in this laboratory is to understand the cellular and molecular mechanisms responsible for dysfunction of afferent and efferent ganglionic neurons in experimental diabetes and chronic heart failure (CHF). The arterial baroreflex is an important component of the body's neural cardiovascular control circuit. Baroreceptors and postganglionic neurons (including postganglionic sympathetic and parasympathetic neurons) serve as primary afferent and efferent limbs of the arterial baroreflex, respectively. Dysfunction of primary afferent and efferent limbs of the arterial baroreflex is likely to be involved in the blunted baroreflex sensitivity, and resultant impairment of cardiac contractility and rhythm stability observed in the diabetes and CHF states. The changes in baroreflex, endogenous substances (such as angiotensin II, nitric oxide, etc), oxidative stress (such as reactive oxygen species, ROS), chronic inflammation (such as inflammatory cytokines), neuronal function (such as cell membrane excitability and ion channel function), and cardiac function are investigated at the molecular, cell, organ and intact animal levels. 

Dr. Yulong Li Scheme

Recent Publications:

  1. Zhang D, Wang D, Pipinos II, Muelleman RL, Li YL.  Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia-reperfusion.  Acta Physiol (Oxf). 2017 Feb; 219(2):453-464.  PMID: 27306588
  2. Tu H, Zhang D, Corrick RM, Muelleman RL, Wadman MC, Li YL. Morphological regeneration and functional recovery of neuromuscular junctions after tourniquet-induced injuries in mouse hindlimb. Front Physiol 2017; 8: 207. PMID: 28428759
  3. Zhang D, Tu H, Wang C, Cao L, Muelleman RL, Wadman MC, Li YL. Correlation of ventricular arrhythmogenesis with neuronal remodeling of cardiac postganglionic parasympathetic neurons in the late stage of heart failure after myocardial infarction. Front Neurosci 2017; 11: 252. PMID: 28533740
  4. Zhang D, Tu H, Cao L, Zheng H, Muelleman RL, Wadman MC, Li YL. Reduced N-type Ca++ channels in atrioventricular ganglion neurons are involved in ventricular arrhythmogenesis. J Am Heart Assoc 2018; 7: e007457. PMID: 29335317
  5. Corrick RM, Tu, H, Zhang D, Muelleman RL, Wadman MC, Li YL. Dexamethasone protect against tourniquet-induced acute ischemia-reperfusion injury in mouse hindlimb. Front Physiol 2018; 9: 244. PMID: 29615933