Shyamal K. Roy

Shyamal K. RoyProfessor
Ph.D. 1980, All-India Institute of Medical Sciences
Major interest: Reproductive Endocrinology
Specialty: Endocrine regulation of follicular development, growth factors, signal transduction in ovarian cells, and biochemistry of granulosa cells
Curriculum Vitae

Estrogen is a female reproductive hormone that regulates a variety of physiological processes.  Evidence indicates that estrogen stimulates the multiplication of granulosa cells that are present in ovarian follicles, and regulates their functions.  However, the mechanisms underlying the estrogen effects on granulosa cell functions remain unclear.  Similarly, despite sporadic information, the role of estrogen in regulating primordial follicle formation in mammals is not clearly understood.  Primordial follicles represent a finite pool of early follicles that provide follicles for ovulation throughout the reproductive life of a female.  A significant number of primordial follicles die during ovary development, and an early depletion of this pool leads to premature ovarian failure, and infertility due to ovarian causes.  Therefore, understanding the factors regulating the formation and development of primordial follicles and the mechanisms of such regulation may lead to improved therapeutic management of infertility.

Working hypothesis image

Recent publications:

  1. Chakraborty P, Roy SK.  Bone morphogenetic protein 2 promotes primordial follicle formation in the ovary.  Sci Rep. 2015 Jul 29; 5:12664. PMID: 26219655
  2. Chakraborty P, Roy SK. Expression of FSH receptor in the hamster ovary during perinatal development. Mol Cell Endocrinol. 2015 Jan 15; 400:41-7. PMID:25462586
  3. Chakraborty P, Roy SK. Effect of azaline B on follicular development and functions in the hamster. Molecular and Cellular Endocrinology, 400, 1-9, 2014. PMID:25462584
  4. Mukherjee A, Roy SK Expression of ErbB3-binding protein-1 (EBP1) during primordial follicle formation: Role of estradiol-17β. PLoS One. 2013 Jun 20; 8(6):e67068. PMID:23840586
  5. Chakraborty P, Roy SK. Expression of estrogen receptor α36 (ESR36) in the hamster ovary throughout the estrous cycle: Effects of gonadotropins. PLoS One. 2013; 8(3):e58291.  PMID:23555574