George J. Rozanski

George J. RozanskiProfessor and Vice Chair of Medical Education
Ph.D. 1981, Loyola University of Chicago
Specialty: Cellular Cardiac Electrophysiology
Major Interest: Cellular basis of bio-electric properties
Curriculum Vitae

Ventricular arrhythmias are a major clinical problem contributing to the high incidence of sudden death in chronic disease states that are characterized by a pathophysiological process termed electrical remodeling. The purpose of our research is to explore the cellular and molecular mechanisms of electrical remodeling in experimental models of heart failure such as chronic myocardial infarction and diabetes mellitus. We propose that toxic molecules of oxygen, so-called reactive oxygen species (ROS), inhibit specific, voltage-gated K+ channels in the failing heart, causing abnormal electrical activity, depressed contractile performance, and arrhythmias. We further postulate that cardiac cells normally have endogenous systems that protect and repair the damage to ion channels and other proteins created by ROS. We have found that these repair systems are down-regulated in ventricular myocytes from failing hearts. In our projects, we examine ways to stimulate the activities of these repair mechanisms in myocytes to restore K+ channel activity to normal. Our findings may lead to the development of novel, therapeutic strategies to prevent or reverse cardiac arrhythmias in chronic heart failure.
reactive oxygen species (ROS)

Recent publications

  1. Wang HJ, Rozanski GJ, Zucker IH.  Cardiac sympathetic afferent reflex control of cardiac function in normal and chronic heart failure states.  J Physiol. 2017 Apr 15;595(8):2519-2534. PMID: 28116751
  2. Wang HJ, Wang W, Cornish KG, Rozanski GJ, Zucker IH. Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure. Hypertension. 2014 Oct;64(4):745-55.  PMID:24980663
  3. Wang HJ, Wang W, Patel KP, Rozanski GJ, Zucker IH. Spinal cord GABA receptors modulate the exercise pressor reflex in decerebrate rats. Am J Physiol Regul Integr Comp Physiol. 2013 Jul 1;305(1):R42-9.  PMID:23637133
  4. Zheng MQ, Li X, Tang K, Sharma NM, Wyatt TA, Patel KP, Gao L, Bidasee KR, Rozanski GJ.  Pyruvate restores β-adrenergic sensitivity of L-type Ca(2+) channels in failing rat heart: role of protein phosphatase. Am J Physiol Heart Circ Physiol. 2013 May 15;304(10):H1352-60. PMID:23504177
  5. Shao CH, Tian C, Ouyang S, Moore CJ, Alomar F, Nemet I, D'Souza A, Nagai R, Kutty S, Rozanski GJ, Ramanadham S, Singh J, Bidasee KR. Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus. Mol Pharmacol. 2012 Sep;82(3):383-99. PMID:22648972