Neeru Sharma
Neeru Sharma

Assistant Professor
Ph.D., 1999, College of Basic Science and Humanities
Specialty: Molecular Cardiovascular Physiology
Major Interest: Molecular basis for the regulation of sympathoexcitation.
Curriculum Vitae

Research in the laboratory is focused on the neural regulation of cardiovascular function in normal and disease states. Our central hypothesis is that activated intracellular signaling cascades in the paraventricular nucleus (PVN) of the hypothalamus contribute to the exaggerated sympathoexcitation.  We are trying to delineate the underlying molecular mechanism of down-regulation of nNOS contributing to increased sympathoexcitation at transcriptional and post-translational level. We were able to unfold a novel regulatory mechanism involving two endogenous nNOS inhibitors: CAPON and PIN. Silencing of CAPON and PIN leads to increase in nNOS levels with concurrent decrease in ubiquitin-mediated degradation of nNOS in the PVN. My main focus is to study the coordinated interplay of transcription, phosphorylation and ubiquitination on nNOS and other regulatory proteins in the brain affecting the sympathoexcitation in cardiovascular diseases specifically heart failure, diabetes and depression. The molecules and the signaling pathways involved in this regulation will be important therapeutic targets for better management of cardiovascular diseases. Overall, my research employs the integrative approach to investigate the neural regulation of cardiovascular function through biochemical and molecular techniques applied to rodent models and neuronal and glial in vitro cell cultures

Recent Publications

  1. Patel KP, Xu B, Liu X, Sharma NM, Zheng H.  Renal Denervation Improves Exaggerated Sympathoexcitation in Rats With Heart Failure: A Role for Neuronal Nitric Oxide Synthase in the Paraventricular Nucleus.  Hypertension. 2016 May 16.  PMID: 27185748
  2. Zheng H, Liu X, Sharma NM, Li Y, Pliquett RU, Patel KP.  Urinary Proteolytic Activation of Renal Epithelial Na+ Channels in Chronic Heart Failure.   Hypertension. 2016 Jan; 67(1):197-205.  PMID: 26628676
  3. Sharma NM, Rabeler B, Zheng H, Raichlin E, Patel KP.  Exercise Training Attenuates Upregulation of p47(phox) and p67(phox) in Hearts of Diabetic Rats.  Oxid Med Cell Longev. 2016; 2016:5868913.  PMID: 26989452
  4. Llewellyn TL, Sharma NM, Zheng H, Patel KP.  Effects of exercise training on SFO-mediated sympathoexcitation during chronic heart failure.  Am J Physiol Heart Circ Physiol. 2014 Jan 1; 306(1):H121-31.  PMID: 24163080
  5. Sharma NM, Llewellyn TL, Zheng H, Patel KP.  Angiotensin II-mediated post-translational modification of nNOS in the PVN of rats with CHF: Role for PIN.  Am J Physiol Heart Circ Physiol. 305 (6): H843-55. PMID: 23832698