Saraswathi Viswanathan
Saraswathi Viswanathan

Assistant Professor
Ph.D., 1999, University of Madras, Chennal , India
Specialty: Obesity, Type 2 Diabetes, and Cardiovascular Disease
Major Interest:
To study the interplay between inflammation and metabolism in modulating obesity-linked metabolic diseases
Curriculum Vitae

The overall focus of our laboratory is to determine the link between obesity and cardiovascular disease.  Obesity is a growing worldwide concern, and the mechanism by which it leads to other metabolic disorders such as insulin resistance (IR), dyslipidemia, and non-alcoholic fatty liver disease is an area of intense research.  Adipose tissue (AT) is a storage reservoir for excess energy in the form of triglycerides (TGs).  In addition to storing TGs, AT secretes several factors called adipokines into the plasma which in turn, regulate glucose and lipid metabolism.  It is becoming clear that it is not the obesity per se but the AT-specific inflammation which is more critical in modulating the features of metabolic syndrome.  AT-inflammation impairs the storage and secretory functions of AT thereby leading to other metabolic disorders.  While arachidonic acid-derived eicosanoid metabolites regulate several physiological and pathological processes, their role in modulating inflammation as it relates to metabolic syndrome is not clear.  Using nutritional, genetic, and pharmacological approaches, we sought to determine the role of eicosanoid signaling in modulating obesity-associated metabolic disorders. 


Viswanathan-Figure

Recent Publications
  1. Saraswathi V, Ganesan M, Perriotte-Olson C, Manickam DS, Westwood RA, Zimmerman MC, Ahmad IM, Desouza CV, Kabanov AV.  Nanoformulated copper/zinc superoxide dismutase attenuates vascular cell activation and aortic inflammation in obesity. Biochem Biophys Res Commun. 2016 Jan 15; 469(3):495-500.  PMID: 26692492
  2. Perriotte-Olson C, Adi N, Manickam DS, Westwood RA, Desouza CV, Natarajan G, Crook A, Kabanov AV, Saraswathi V.  Nanoformulated copper/zinc superoxide dismutase reduces adipose inflammation in obesity. Obesity (Silver Spring). 2016 Jan; 24(1):148-56.  PMID: 26612356
  3. Adi N, Perriotte-Olson C, Desouza CV, Ramalingam R, Saraswathi V.  Hematopoietic cyclooxygenase-2 deficiency increases adipose tissue inflammation and adiposity in obesity. Obesity (Silver Spring). 2015 Oct; 23(10):2037-45. PMID: 26316178
  4. Murali G, Desouza CV, Clevenger ME, Ramalingam R, Saraswathi V.  Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes.  Prostaglandins Leukot Essent Fatty Acids. 2014 Jan; 90(1):13-21. PMID: 24332315
  5. Saraswathi V, Ramnanan CJ, Wilks AW, Desouza CV, Eller AA, Murali G, Ramalingam R, Milne GL, Coate KC, Edgerton DS.  Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice. Metabolism. 2013 Nov; 62(11):1673-85.  PMID: 23987235