Hong Zheng
Hong Zheng

Assistant Adjunct Professor
M.D. 1993, Peking University Health Science Center
Specialty: Neural control of circulation and autonomic function
Major Interest: Central mechanisms regulating sympathetic outflow in normal and disease states
Curriculum Vitae

Research in the laboratory is concerned with the regulation of sympathetic outflow in normal and disease states. Type 2 diabetes is one of the diseases with the greatest risk of developing cardiovascular disease. Accumulated evidence indicates that type 2 diabetes is associated with enhanced sympathetic neural drive. Chronic sympathetic activation increases the risk of cardiovascular complications and subsequent mortality during type 2 diabetes. Our central hypothesis is that enhanced leptin-glutamate signaling in the hypothalamic nuclei contributes to the exaggerated sympatho-excitation in rats with type 2 diabetes The questions are addressed using high fat and low dose streptozotocin-induced type 2 diabetic rats to define the precise mechanisms (leptin-glutamate signaling) and specialized cells (neuron-astrocyte interaction) within the hypothalamus that lead to sympatho-excitation in type 2 diabetes. Furthermore, we also study the effects of leptin through transient receptor potential canonical channels contributing to the exaggerated sympathetic activation in type 2 diabetes. The project is addressed by using whole animal study, electrophysiological study, genetic manipulation, immunohistochemistry, confocal image, neuronal cell culture and molecular biology techniques.

Dr. Zheng's research image

Recent Publications:

  1. Zheng H, Liu X, Sharma NM, Patel KP. Renal denervation improves cardiac function in rats with heart failure: effects on expression of β-adrenoceptors. Am J Physiol Heart Circ Physiol. 2016 Jun 10:ajpheart.00999.2015. doi: 10.1152/ajpheart.00999.2015. [Epub ahead of print]   PMID:27288440             
  2. Patel KP, Xu B, Liu X, Sharma NM, Zheng H.  Renal Denervation Improves Exaggerated Sympathoexcitation in Rats With Heart Failure: A Role for Neuronal Nitric Oxide Synthase in the Paraventricular Nucleus.  Hypertension. 2016 Jul;68(1):175-84. PMID: 27185748
  3. Zheng H, Liu X, Sharma NM, Li Y, Pliquett RU, Patel KP.  Urinary Proteolytic Activation of Renal Epithelial Na+ Channels in Chronic Heart Failure.  Hypertension. 2016 Jan; 67(1):197-205. PMID:26628676 
  4. Zhang D, Liu J, Zheng H, Tu H, Muelleman RL, Li YL.  Effect of angiotensin II on voltage-gated sodium currents in aortic baroreceptor neurons and arterial baroreflex sensitivity in heart failure rats.  J Hypertens. 2015 Jul; 33(7):1401-10.  PMID: 25827427
  5. Xu B, Zheng H, Liu X, Patel KP.  Activation of afferent renal nerves modulates RVLM-projecting PVN neurons.  Am J Physiol Heart Circ Physiol. 2015 May 1; 308(9):H1103-11.  PMID: 25637549