A position is available in the Department of Pediatrics at the University of Nebraska Medical Center, to work under the direction of Professor Donald Durden and Joseph Garlich of SignalRx Pharmaceuticals, Inc. (https:www.signalrx.com) to synthesize, purify and characterize libraries of small molecules for biological and/or DMPK evaluation.

Also under Drs. Durden/Garlich’s direction, the successful candidate will develop structure activity relationships and design new targets with the potential to provide improved compounds and deliver novel therapeutics. This postdoctoral research associate will be responsible for the synthesis and characterization of small molecule target compounds, writing laboratory reports, and participating in laboratory meetings. In addition, this postdoctoral research associate will design target compounds, propose synthetic pathways, and analyze and interpret data related to the project. Dr. Durden’s Lab resides in the new state-of-the-art Buffett Cancer Center building on the campus of UNMC in Omaha.

A position is available in the Department of Pediatrics, University of Nebraska Medical Center, to work under the direction of Professor Donald Durden and Guillermo Morales of SignalRx Pharmaceuticals, Inc. (https:www.signalrx.com) to use computer assisted drug discovery in silico platform software to design small molecule inhibitors of important target molecules related to human disease pathology.

Also under Drs. Durden/Morales’s direction, the successful candidate will develop structure activity relationships and design new targets with the potential to provide improved compounds and deliver novel therapeutics. The candidate will be responsible for the synthesis and characterization of small molecule target compounds, writing laboratory reports, and participating in laboratory meetings. in addition, the candidate will design target compounds in silico, propose synthetic pathways, and analyze and interpret data related to the project. Dr. Durden’s Lab resides in the new state-of-the-art Buffett Cancer Center building on the campus of UNMC in Omaha.

Ph.D. in scientific field, preferably Immunology/Virology

Possess extensive knowledge in the field of drugs of abuse in HIV-infected patients, which would help in contributing towards clinical and translation efforts in HIV research.

Ability to perform flow cytometry, sorting cells using FACS and perform reservoir assays, such as viral outgrowth assay and TILDA assays etc.

Strong publication record and excellent oral and written communication skills.

Ability to demonstrate experience maintaining organized data, working collaboratively in a team-oriented environment, conceptualizing and prioritizing objectives and exercising independent judgment.

Advanced theoretical understanding of the subject and work being performed required.

• Ph.D. or equivalent degree in materials science and engineering or biomedical engineering
• A strong background in biomaterials, tissue engineering, regenerative medicine, neurological science, and/or other medical research
• Substantial polymer synthesis or animal research experience
• Excellent oral and communication skills with strong publication records
• Self-motivated with the ability to work independently in various projects

A post-doctoral position in the Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, is immediately available. Research in our group focuses on the assessing role of extracellular vesicles (EVs) as cell-cell communication conduits, EV biogenesis and EVs as agents for delivery of therapeutics in the CNS. For more information, please check the group website at https://www.unmc.edu/pharmacology/faculty/primary-faculty/buch/index.html and
https://www.unmc.edu/pharmacology/faculty/primary-faculty/hu/index.html.

The successful candidate will work on the methods and applications of EV approaches to handle unmet challenges in neuropathogenesis and therapeutics.

Work will involve characterization of the EVs from cells supernatants, tissues and plasma using a number of sophisticated characterization techniques including TEM, confocal microscopy, flow cytometry, and AFM, etc. The candidate is expected to have extensive knowledge and skills in RNA biology, biochemistry with skills in bioinformatics as a plus. The position will also entail conducting in vitro cell culture and in vivo animal work. The individual will conduct data analysis, reporting, and manuscript writing and will work in a highly interdisciplinary and collaborative academic environment. This position is funded by NIH and will support a postdoc for 4-5 years with a competitive salary and benefits.

Experience in the basic principles of aerosol measurement, basic principles of laboratory microbiology to include: bacterial and/or viral culture methods, molecular methods including nucleic acid isolation and quantitative PCR.

Demonstrated writing ability and existing publications.

https://unmc.peopleadmin.com/postings/40453

https://unmc.peopleadmin.com/postings/40454

The post-doctoral research associate will work in the DICON Laboratory and MEG Center with the principle investigator and research team to plan, develop, implement, and conduct scholarly research at UNMC. This includes ongoing NIH and NSF funded research in healthy aging and development, as well various neurological populations.. Duties may involve research study design, participant recruitment, data collection, data analyses, writing manuscripts and grants, as well as scholarly presentations. Data include cognitive assessments, MEG and MR imaging data, the outcomes of various psychophysics experiments, electronic medical record data, and other forms of data. The candidate will also help prepare research progress reports and grant applications, publications, and institutional review board and other compliance reports as directed. The selected candidate will also work as directed with collaborators internal and external to UNMC.

Please submit a curriculum vitae or NIH biosketch and a one-page cover letter detailing research experience and career goals. Contact information for three individuals who will provide letters of recommendation will be requested at a later time.
Review of applications will begin immediately and will continue until the positions are filled. Start dates are negotiable.

Individuals from diverse backgrounds are encouraged to apply.

1. Ph.D. in neuroscience, psychology, physics, or related scientific field
2. Strong research writing and communication skills
3. Microsoft Excel, Microsoft Word, Microsoft PowerPoint
4. Ability to operate standard office equipment (computer, copy machine)
5. Exceptional organizational skills; ability to communicate efficiently and
effectively both verbally and in writing.
6. Ability to work as a team member
7. Self-directed
8. Able to advise and supervise more junior laboratory personnel

1. Proficiency in experimental design and implementation, multivariate analysis and statistical modeling.
2. Experience with MEG, structural MRI, and/or functional MRI
3. Matlab, SPSS, R, SPM, FSL, AFNI
4. Experience with Endnote and Photoshop. Familiarity with Unix, Linux, and Windows operating systems.
5. Clinical research protocol experience, ability to “troubleshoot” laboratory specialized equipment in connection with relevant technicians and vendors.

The person in this position will be responsible for the mechanistic studies for exploring the role of oncogenes in the development and progression of the pancreatic cancer. His/her studies will focus on the development of diagnostic and prognostic assay for novel biomarkers.

Required Qualification

The Mind & Brain Health Labs (MBHL) at the University of Nebraska Medical Center’s Department of Neurological Sciences is seeking a Postdoctoral Research Associate with a background in human behavioral research (basic and clinical) in a relevant field. Relevant fields include (but are not limited to) Computer Science, Behavioral Sciences (Psychology, Cognitive Science, Neuroscience, and Human Factors), Statistics, and Engineering. The Postdoctoral Research Associate should have strong data analytic and research skills. The Postdoctoral Research Associate will play a primary role in the analysis of large, naturalistic datasets on real-world driving behavior, performance, and safety in individuals with and without disease. Analyses will incorporate multidimensional data, including driving, medical, physiologic, computer vision, and geographic information system (GIS) data.

The Postdoctoral Research Associate will intellectually develop research questions and analyses, including contributing to the development of new research questions and funding proposals. This is a great opportunity to get experience with novel datasets and clinical translational research on modeling human performance and safety in real-world settings, in addition to building a CV with presentations, publications, and funded grants.

The Postdoctoral Research Associate will:
o Identify, intellectually develop, and implement research questions on human behavior, physiology, and neurocognitive performance in the context of complex environments, human-machine interactions, and disease.
o Use statistical analyses and other data science approaches to manipulate, analyze, and provide answers to research questions using large amounts of structured and unstructured data.
o Apply your research results (positive and null) to develop future clinical translational research programs and intervention techniques.
o Work closely with MBHL research staff and collaborators (internal and external) to develop innovative new research ideas and data analyses.
o Share research findings with the broader academic community through peer-reviewed conference presentations and publications.
o Follow IRB Protocol, HIPAA, and Standard Operating Procedures in Human Subjects Research.

MBHL (https://www.unmc.edu/mbhl/) is an interdisciplinary group of researchers who are committed to clinical translational research on real-world behavior and safety in healthy and patient populations. Our collaborative team combines expertise from medicine, cognitive science, neuroscience, human factors, driving research, statistics, computer science, biomechanics, and public policy. We focus on understanding how humans behave when interacting with technology in-the-lab and in-the-field, with a focus on mobility and cognition. To address these questions, we study human behavior in the context of human-machine interactions and in complex environments using novel technologies for monitoring of functional abilities, physiology, and performance. We use the results of our research to inform patient and clinician education, policy, and technology development with the goal of improving health, mobility, and quality of life in individuals of all ages.

Questions may be directed to Jennifer Merickel, PhD at jennifer.merickel@unmc.edu

Individuals from diverse backgrounds are encouraged to apply.

Open until filled

Engage in full-time advanced research training under the supervision and direction of faculty sponsor in the sponsor’s research program. Supported by the College and, as appropriate, by the sponsor’s grants. Must relocate to the sponsor’s location for active participation in the sponsor’s program of research and to take advantage of the many interdisciplinary scientific opportunities afforded by the University.

Program outcomes focus on accelerating the trainee’s entry into a research career and include: 1) give a minimum of one research presentation per year (e.g. conference, meeting, seminar, or brown bag); 2) Attend/watch a minimum of 8 out of 12 monthly lectures/seminars that support your research; 3) Submit a grant proposal as Principal Investigator to NIH or other appropriate funding source each year or until funding is received; 4) Submit a minimum of two refereed journal articles as first author; 5) Submit a minimum of one abstract for a presentation at a regional or national research conference

1) PhD prepared applicants with evidence of past academic achievement and scholarly productivity,
2) Master’s or PhD in Nursing required (other graduate degree may be in a related field,
3) Match of interest with UNMC College of Nursing sponsor is critical,
4) Registered nurse license in U.S. (Nebraska)