Hyung Joon Kim, PhD

Hyung Joon Kim

Assistant Professor

For Information Call 402.559.0707

Academic Office:

Durham Research Center II, Room 6034

985965 Nebraska Medical Center

Education:

Postdoctoral Fellowship

Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla CA, 2017.

Ph.D. in Materials Science and Engineering, University of California, Irvine CA, 2010.

B.S./M.S. in Materials Science and Engineering, POSTECH, South Korea, 1997/1999.

Research

My laboratory has worked on measuring the pathophysiologically relevant molecular and cellular deficits in human brain diseases.  Neurons, glia, and their niche factors are essential components of the functional integrity of the brain in healthy normal and disease states.  By manipulating cellular and niche components in an engineering dish, we have studied the mitochondria dysfunction in Alzheimer’s and Schizophrenia, axon pathfinding, dendritic morphogenesis of adult-born neurons, and glia-neuron interaction. The hippocampus-associated changes in the molecular signaling and circuit property have been commonly implicated in many neurodegenerative and psychiatric disorders including Alzheimer’s, Schizophrenia, and PTSD (post-traumatic stress disorder).  However, there is lack of methods representing the human disease-relevant physiology in vitro.  Using human patient’s induced pluripotent stem cells (hiPSCs) and engineering tissue scaffold, we aim to develop a microphysiological model system recapitulating the changes in the interaction between neuronal, glial, and neurovascular cells.

Grants

  1. Nebraska Stem Cell Research Project Grant

MSC derived myelinating Schwann cell for peripheral nerve regeneration.

Co-Investigator (10/2017-06/2018)

  1. Mary & Dick Holland Regenerative Medicine Program Pilot Grant

Develop human neural progenitor-based in vitro models for mild traumatic brain injury

PI (01/2018-12/2018)

  1. Mary & Dick Holland Regenerative Medicine Program Pilot Grant

Microphysiological System for Modeling the Hippocampal Integrity

PI (05/2018-04/2019)

  1. University of Nebraska Collaboration Initiative/System Science Seed Grant

Growth Factor Dynamics and Regenerative Capacity of Gustatory and Somatosensory Systems Using Microfluidics

Co-Investigator (07/2018-06/2020)

Publications (Selected)

Full list of publication

 

  1. Han J., Kim H.J.*, Schafer S.T.*, Paquola A., Clemenson G.D., Toda T., Oh J., Pankonin A.R., Lee B.S., Sarkar A., Johnston S.T., Denli A.M., and Gage F.H., Functional implications of miR-19 in the migration of newborn neurons in the adult brain, Neuron, July 6 (2016) 91(1): 79-89, DOI: http://dx.doi.org/10.1016/j.neuron.2016.05.034 (*equal contribution)
  2. Kim H.J.*, Denli A.M.*, Wright R., Baul T.D., Clemenson G.D., Morcos A.S., Zhao C., Shafer S., Gage F.H., and Kagalwala M.N., REST regulates non- cell autonomous neuronal differentiation and maturation of neural progenitor cells via secretogranin II, J. Neurosci, November 4 (2015) 35(44):14872–14884, DOI:10.1523/JNEUROSCI.4286-14.2015 (*equal contribution)
  3. Kerman B.E., Kim H.J., Mei A., Padmanabhan K., Georges S., Jones M., Fitzpatrick J., Jappelli R., Chandross K., August P., and Gage F.H. (2015), In vitro myelination using embryonic stem cells, Development, 142, 1-13 doi:10.1242/dev.116517.
  4. Deshmukh, V. A., Tardif, V., Lyssiotis, C. A., Green, C. C., Kerman, B., Kim, H. J., Padmanabhan, K., Swoboda, J. G., Ahmad, I., Kondo, T., Gage, F. H., Theofilopoulos, A. N., Lawson, B. R., Schultz, P. G., and Lairson, L. L. (2013) A regenerative approach to the treatment of multiple sclerosis, Nature 502, 327-332.
  5. Butko, M. T., Yang, J., Geng, Y., Kim, H. J., Jeon, N. L., Shu, X., Mackey, M. R., Ellisman, M. H., Tsien, R. Y., and Lin, M. Z. (2012) Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy, Nat Neurosci. 15, 1742-1751.
  6. Kim, H. J., Park, J. W., Byun, J. H., Poon, W. W., Cotman, C. W., Fowlkes, C. C., and Jeon, N. L. (2012) Quantitative Analysis of Axonal Transport by Using Compartmentalized and Surface Micropatterned Culture of Neurons, ACS Chemical Neuroscience 3, 433-438.
  7. Kim, H. J., Park, J. W., Byun, J. H., Vahidi, B., Rhee, S. W., and Jeon, N. L. (2012) Integrated Microfluidics Platforms for Investigating Injury and Regeneration of CNS Axons, Ann Biomed Eng.
  8. Cohen, M. S., Bas Orth, C., Kim, H. J., Jeon, N. L., and Jaffrey, S. R. (2011) Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites, Proc Natl Acad Sci U S A 108, 11246-11251.
  9. Hengst, U., Deglincerti, A., Kim, H. J., Jeon, N. L., and Jaffrey, S. R. (2009) Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein, Nat Cell Biol 11, 1024-1030.

Lab Members

Kathy Chu (Research technologist) B.S. Syracuse University

Seokyoung Bang (Postdoctoral scholar): Ph.D. Seoul National University

Anamaria Guzman .C. (Undergraduate): University of Nebraska Lincoln

Wenzhu Zhang (Visiting scholar): Ph.D. China Medical University

Inquiry for an opening should be addressed to Hyung Joon Kim (hyungjoon.kim@unmc.edu).