PASSAGE-1000 Days

Pan-African Sepsis Study - Advancing Science and Gathering Evidence:

This new endeavor has been designed in close collaboration with international experts to repeat the R0-1 funded Indian clinical trial of probiotics in Africa. Apart from repeating the clinical trial, this study aims at in-depth evaluation of innate and acquired immunity during neonatal and infancy. Changes in gut microbiota in the diverse African settings during child development and probiotic therapy is also a major aim of this study. In a population-based study, neonates and infants will be followed for the first 1000 days of their lives (including in-utero period) where various maternal and environmental factors and nutritional assessments will be done for comprehensive examination of their impact on maternal, neonatal, and infant health and development.

The PASSAGE research collaborative, along with an investigators meeting was co-organized by leading experts from University of British Columbia and University of Nairobi Institute of Tropical and Infectious Diseases (UNITID) in the summer of 2014, with Dr. Pinaki Panigrahi as the Principal Investigator from UNMC. Other investigators included domain experts in infectious disease, clinical trials, probiotics, bio-informatics, gut microbiota, mucosal immunology, and vaccinology. At present the consortium includes senior faculty members from McMaster University, Dalhousie University, Lawson Health Research Institute-Western Ontario; University of Nairobi; Kenya AIDS Control Project KACP- University of Manitoba/ Nairobi; the Bandim Health Project in Guinea-Bissau; Spain’s CRESIB in affiliation with Manhiça Health Research Centre, Mozambique; Eagle Research Centre in Kigali, Rwanda; Kigali University Teaching Hospital (CHUK); Uganda’s Mabara University of Science and Technology (MUST); Department of Pathology & Molecular Medicine-Aga Khan University, Kenya, Minia University, Egypt, Department of Microbiology, Viral Hepatitis Research Laboratory (VHRL), and the Egyptian National Hepatology and Tropical Medicine Research Institute (NH-TMRI); and the Center for Global Health and Development, CoPH, UNMC