MEMRI-Based NOD/scid-IL-2Rnullγc Mouse Brain Atlas

As NOD/scid-IL-2Rγcnull (NSG) mice allow human cell transplantation to study human disease, these animals are used to assess brain morphology. NSG adult mouse brains were imaged in vivo on a 7.0 Tesla MR scanner at an isotropic resolution of 100 µm. A population averaged brain of 19 mice was generated using an iterative alignment algorithm. MEMRI provided sufficient contrast permitting 41 brain structures to be manually labeled.

MEMRI provided sufficient contrast permitting 41 brain structures to be manually labeled.

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Balasrinivasa R. Sajja, Aditya N. Bade, Biyun Zhou, Mariano G. Uberti, Santhi Gorantla, Howard E. Gendelman, Michael D. Boska, and Yutong Liu. Generation and Disease Model Relevance of a Manganese Enhanced Magnetic Resonance Imaging- Based NOD/scid-IL-2Rγcnull Mouse Brain Atlas. J Neuroimmune Pharmacol. 2016 Mar; 11(1): 133–141.