Sicong Li, D.Sc.


Sicong Li, D.Sc.

Sicong Li, D.Sc.

Associate Professor

D.Sc. - Engineering (Systems Science and Math); Washington University, St. Louis, MO; 1999
MS - Systems Science and Mathematics; Washington University, St. Louis, MO; 1997
MS - Electromechanical Engineering; Nanjing University; China; 1989

American Board of Radiology - Therapeutic Radiological Physics

Professional Memberships:
American Association of Physicists in Medicine (AAPM)
IEEE, Electronic Engineering

Clinical & Research Interests:
3-D Conformal Treatment Planning
Intensity Modulated Radiation Therapy (IMRT)
Stereotactic Radiosurgery

Research Projects:

  1. The stereotactic radiosurgery and stereotactic body radiotherapy:
    1. Treatment positioning accuracy.
    2. Optimization of beam orientation, weighting, and conformation.
    3. Treatment delivery technologies.
    4. Normal tissue dose tolerance.
  2. The brachytherapy treatments:
    1. Radiobiological models of the biological equivalent doses.
    2. Accuracy in brachytherapy dose calculations with heterogeneity corrections.
    3. MRI guided planning and treatments.
    4. Applications in IORT.
  3. The intensity modulation radiotherapy and volumetric modulated arc therapy:
    1. Optimization algorithms for inverse planning.
    2. Small field dose calculation.
    3. Quality assurance of the treatment delivery.
    4. Treatment delivery efficiency and safety.
  4. Various special procedures of radiotherapy:
    1. Total body Irradiations.
    2. Total skin electron therapy.
    3. Intraoperative radiation therapy.


  1. Venugopal Gunda, Joshua J. Souchek, Jaime Abrego, Surendra K. Shukla, Gennifer D Goode, Enza Vernucci, Aneesha Dasgupta, Nina Chaika, Ryan J King, Sicong Li, Shuo Wang, Fang Yu, Tadayoshi Bessho, Chi Lin and Pankaj K Singh, MUC1-mediated metabolic alterations regulate response to radiotherapy in pancreatic cancer, Clinical Cancer Research, Published Online First, doi: 10.1158/1078-0432.CCR-17-1151, 2017
  2. Zhang Q, Driewer J, Wang S, Li S, Zhu X, Zheng D, Cao Y, Zhang J, Jamshidi A, Cox BW, Knisely JPS, Potters L, Klein EE, Accuracy evaluation of a six-degree-of-freedom couch using cone beam CT and IsoCal phantom with an in-house algorithm, Med Phys. 44(8):3888-3898, 2017
  3. Macha, M. A. , Rachagani, S. , Qazi, A. K. , Jahan, R. , Gupta, S. , Patel, A. , Seshacharyulu, P. , Lin, C. , Li, S. , Wang, S. , Verma, V. , Kishida, S. , Kishida, M. , Nakamura, N. , Kibe, T. , Lydiatt, W. M. , Smith, R. B. , Ganti, A. K. , Jones, D. T. , Batra, S. K., Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells, Oncotarget. 8, 13, p. 20961-20973, 2017
  4. Chen, Y. G., Chen, M. Q., Guo, Y. Y., Li, S. C., Wu, J. X. & Xu, B. H., Apparent diffusion coefficient predicts pathology complete response of rectal cancer treated with neoadjuvant chemoradiotherapy, PLoS One. 11, 4, e0153944, 2016
  5. Zhou, S., Zhu, X., Zhang, M., Zheng, D., Lei, Y., Li, S., Bennion, N., Verma, V., Zhen, W. & Enke, C., Estimation of internal organ motion-induced variance in radiation dose in non-gated radiotherapy, Phys Med Biol., 61, 23, p. 8157-8179, 2016
  6. Bennion, N. R., Nowak, R. K., Lyden, E. R., Thompson, R. B., Li, S. & Lin, C., Fractionated stereotactic radiation therapy for vestibular schwannomas: Dosimetric factors predictive of hearing outcomes, Pract Radiat Oncol, Sep-Oct;6(5):e155-62, 2016
  7. Zhang, M., Zhang, Q., Gan, H., Li, S. & Zhou, S. M, Setup uncertainties in linear accelerator based stereotactic radiosurgery and a derivation of the corresponding setup margin for treatment planning, Physica Medica. 32, 2, p. 379-385, 2016
  8. Verma, V., Johnson, C. P., Bennion, N. R., Bhirud, A. R., Li, S., McComb, R. D. & Lin, C., Atypical teratoid rhabdoid tumor: long-term survival after chemoradiotherapy, Child's Nervous System, 31(8):1393-9, 2015
  9. Lin, C., Lin, J., Stavas, M., Li, S., Canady, K. J., Romberger, D. J. & Loberiza, F. R., Impact of body mass index on pulmonary complications in patients with non-Hodgkin lymphoma treated with hematopoietic stem cell transplant, Leukemia and Lymphoma. 56, 11, p. 3058-3064, 2015
  10. Zhu, X., Driewer, J., Li, S., Verma, V., Lei, Y., Zhang, M., Zhang, Q., Zheng, D., Cullip, T., Chang, S. X., Wang, A. Z., Zhou, S. & Enke, C. A., Technical Note: Fabricating Cerrobend grids with 3D printing for spatially modulated radiation therapy: A feasibility study, Medical Physics. 42, 11, p 6269-6273, 2015
  11. Zhang, Q., Zheng, D., Lei, Y., Morgan, B., Driewer, J., Zhang, M., Li, S., Zhou, S., Zhen, W., Thompson, R., Wahl, A., Lin, C. & Enke, C, A new variable for SRS plan quality evaluation based on normal tissue sparing: The effect of prescription isodose levels, Nov 1 2014 In : British Journal of Radiology. 87, 1043, 20140362, 2014
  12. Guang Han,  Dong Liu,  Hua Gan,  Kyle A. Denniston,  Sicong Li,  Wenyong Tan,  Desheng Hu, Weining Zhen,  Zhaohua Wang,  Evaluation of the Dosimetric Feasibility of Hippocampal Sparing Intensity-Modulated Radiotherapy in Patients with Locally Advanced Nasopharyngeal Carcinoma, PloS ONE, 9:2, e90007, 2014
  13. Mutian Zhang, Sicong Li, Hua Deng, Sumin Zhou, Technical Note: The Uses of I’mRT MatriXX in Electron Beams, Int. J of Medical Physics, Clinical Engineering and Radiation Oncology, 2(1) Page 15-18, 2013
  14. Cheng B Saw, Shanglian Bao, Sicong Li, A review on the technical and dosimetric aspects of stereotactic body radiation therapy (SBRT), Journal of Radiation Oncology, 1(4) Page 317-322 2012