Drug development and nanomedicine

Tailoring medication with genetics

Julie Oestreich, PharMD, PhD, knows prescription drugs don’t work the same for everyone.

But, she wants to better understand how genes influence individual drug responses so doctors can prescribe the drug and dosage that works best for the patient being treated.

“I want to know how medicines work and how they change the body to create good — and to sometimes cause harm. Throw genetics into the picture and it’s an interesting and important area of study.”

 Julie Oestreich, PharMD, PhD

Although the field of pharmacogenomics is relatively new, it has the potential to one day eliminate the “one size fits all” medicinal approach and lead to more effective, safe medications and doses tailored to a person’s genetic makeup.

The use of genetic information to guide treatments is growing as physicians better predict who will benefit from a drug, who will not respond at all or who will experience a negative side effect.

An assistant professor of pharmacy practice in the College of Pharmacy, Dr. Oestreich (pronounced ace-try) researches personalized anti-platelet therapy (which medicines, and how much, work best) and  genetic tests for risk factors for cardiovascular events among the area’s American Indian population.

She drives to Martin, S.D., and its surrounding area to find and interact with her research participants. Together, the UNMC team collaborates with Lyle Best, MD, and Turtle Mountain Community College at Belcourt, N.D. Both entities also work with Missouri Breaks Industries Research Inc., which is American Indian-owned and has offices on both the Pine Ridge and Cheyenne River Sioux Reservations in South Dakota.

The project goes through not just UNMC’s Institutional Review Board (IRB) but one with the tribe itself, and one with the Aberdeen Area Indian Health Service.