Core Facilities
Jump to a Core Facility based on the categories listed below or use Control F to search by keyword
ANIMAL MODELS, BEHAVIOR AND PHYSIOLOGY |
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| Resource | Services |
| Animal Behavior Core | Cognitive and behavioral assessments of non-human animal models |
| Biological Irradiation Core | Irradiation of small animals, tissue samples, and cultured cells |
| Comparative Medicine |
Provides professional veterinary medical, husbandry and proposal review services to support animals used in research |
| Echo Facility | Echocardiography, Hemodynamics, and Photoacoustic imaging |
| Electron Paramagnetic Resonance (EPR Spectroscopy) | Free Radical Measurement |
| Environmental Cigarette Smoke Exposure Facility (Cigarette smoke Exposure Studies) | Smoke Machine capable of generating smoke, various compounds, for environmental exposure (aka secondhand smoke or ETS) to rodents. |
| Mouse Genome Engineering Core | DNA Construct, Genotyping, Knockout Animals, Mouse Strain Rederivation, Transgenic Animals, Speed Congenics |
| Mouse Metabolic Monitoring | Calorimetry, DEXA scans, and Home Cage Monitoring for mice |
| Physiological Environment Research Facility (PERF) | Hyperbaric Oxygen controlled environment chamber for live cell analysis |
| Translational Mouse Model Core Facility | Provides humanized mouse models |
BIOIMAGING |
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| Resource | Services |
| Radioactive Antibody Labeling Facility (RALF) | Radiolabeling of proteins, peptides, and small organic molecules |
| Bioimaging Facility | Non-human magnetic imaging and tomography (MRI, CT, SPECT) |
| UNMC Advanced Microscope Core Facility | Confocal Laser Scanning Microscopy, Super Resolution Fluorescent Microscopy, Live Cell Imaging |
| Electron Microscopy Facility | Transmission and Scanning Electron Microscopy |
| IVIS Spectrum in vivo Imaging Core Facility | IVIS optical imaging |
| Multiphoton Intravital & Tissue Imaging Research Core | Intravital imaging equipment to acquire advanced descriptive and qualitative data from live animals and fixed samples requiring deep tissue illumination |
| Nanoimaging Core Facility | Combined AFM/Raman supports nanomanipulations and characterization of mechanical, electrical, magnetic properties of samples. |
| Nanomaterials Characterization Core Facility | Equipment & expertise for the comprehensive study of polymers and nanomaterials. The facility offers: Inductively Coupled Plasma Mass Spectrometer, Surface Plasmon Resonance, Dynamic Light Scattering, Nanoparticle Tracking Analysis, Multimodal Laser Scanner, and Rodent Hematology & Blood Chemistry Analyzers |
| Tissue Sciences Facility | Human and Animal Tissue Pathology, digital Imaging, Slide Scanning, Automated Immunohistochemistry and Specialized Histology |
| Echo Facility | Echocardiography, Hemodynamics, and Photoacoustic imaging, VEVO Ultrasonic Imaging |
| Radiology | Molecular Imaging (PET) Human |
| MEG Center | Magnetoencephalography (MEG) Human |
| Department of Internal Medicine, Cardiology | Cardiovascular Ultrasound |
CELL AND TISSUE ANALYSIS |
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| Resource | Services |
| Biological Irradiation Core | Irradiation of small animals, tissue samples, and cultured cells |
| Biosafety Level 3 Core Facility | Restricted access facility for qualified and authorized researchers to perform studies that involve BSL-3 organisms |
| Electron Paramagnetic Resonance (EPR Spectroscopy) | Free Radical Measurement |
| Tissue Sciences Facility | Human and Animal Tissue Pathology, Digital Imaging, Slide Scanning, Image Analysis, Automated Immunohistochemistry and Specialized Histology |
| Elutriation Core Facility | Isolation of monocytes and lymphocytes from peripheral blood mononuclear cells (PBMCs) |
| Flow Cytometry Research Facility | Flow Cytometry Services, Cell Separation |
| Electron Microscopy Research Facility | Electron Microscopy/Confocal Microscopy |
| UNMC Advanced Microscope Core Facility | Confocal Laser Scanning Microscopy, Super Resolution Fluorescent Microscopy, Live Cell Imaging |
| Multiphoton Intravital & Tissue Imaging Research Core | intravital imaging equipment to acquire advanced descriptive and quantitative data from live animals and fixed samples requiring deep tissue illumination |
| Eppley Cancer Center Molecular Biology and HTS Facility | High-throughput chemical, small molecule, and SiRNA (small interfering RNA) screening, High-content cell imaging and analysis, Luminex xMAP technologies |
| Seahorse Core - DONS Shared Resources | Expertise and training in use of the Agilent Seahorse Extracellular Flux Analyzer for metabolic assays. This platform facilitates simultaneous measurement of the two major energy producing pathways of the cell – mitochondrial respiration and glycolysis, in a multi-well plate, in real time. |
CLINICAL RESEARCH |
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| Resource | Services |
| Biologics Production Facility | GMP Facility for the manufacturing, production and modification of cells, tissues, cellular and tissue-derived products |
| Cancer Research Informatics Office | Development, maintenance and support of data management systems and disease-specific registries and biobanks; Computational tools for studying structure and function of molecules |
| Center for Collaboration on Research Design and Analysis (CCORDA) | Biostatistics, Research Study Design, Surveys and Analysis |
| Center for Clinical and Translational Research | Resources for Clinical Research |
| Center for Reducing Health Disparities | Consultation on Study Design, Spanish translation services for and promotion and enrollment into research studies |
| Clinical Movement Analysis Laboratory | Equipment and resources to support human studies involving physical activity |
| Clinical Research Center | Outpatient clinical research facility provides clinical trial support from pre-proposal planning, to clinical services and training. Clinic and laboratory space to conduct clinical trials and nurse coordinators and support staff for clinical trials. |
| Epigenomics | DNA Methylation Analysis |
| Eppley Cancer Center Protocol Review and Monitoring System | Data & Safety Monitoring |
| Electronic Health Record Data Access Core | Electronic health record access; feasibility, cross-sectional, health-outcomes, retrospective data analysis, quality improvement, registry creation, subject recruitment, public health research studies |
| Elutriation Core Facility | Isolation of monocytes and lymphocytes from peripheral blood mononuclear cells (PBMCs). |
| Eppley Cancer Center Clinical Trials Office | Centralized Protocol and Data Management Unit |
| Human Genetics Laboratory | Cytogenetics, FISH studies, Molecular genetics |
| Institutional Review Board (IRB) | Assure Protection of all human subjects in research projects on the premises of the UNMC, NMC and UNO |
| Investigational Pharmacy | Custom pharmaceutical services for clinical and translational research. Protocol assistance and design, Regulatory Oversight, Inventory Control, Documentation, Dispensing, Drug Information |
| MEG Center | Magnetoencephalography (MEG) Human |
| Nebraska Biobank | Deidentified serum/plasma or DNA samples available for clinical/translational research projects |
| Nebraska Biomechanics Core Facility | Gait analysis, muscular strength testing, endurance analysis, comprehensive balance analysis (on UNO campus) |
| Nebraska Nanomedicine Production Plant | Resources to transition nanomedicines from preclinical screening to human clinical trials, including pre-production advisement and product preparation. |
| UNMC Genomics Core | Next Generation Sequencing , Whole genome sequencing, High Throughput Traditional Sequencing |
| Tissue Banking Core Facility | Tissue for histologic, cytogenetic, immunohistochemical, and molecular analysis |
| Tissue Sciences Facility | Human and Animal Tissue Pathology, Digital Imaging, Slide Scanning, Image Analysis, Automated Immunohistochemistry and Specialized Histology |
DATA ANALYSIS AND STATISTICS |
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| Resource | Services |
| Center for Collaboration on Research Design and Analysis (CCORDA) | Biostatistics, Research Study Design Surveys and Analysis |
GENOMICS |
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| Resource | Services |
| Flow Cytometry Research Facility | Flow Cytometry Services, Cell Separation |
| Eppley Cancer Center Molecular Biology and HTS Facility | High-throughput chemical, small molecule, and SiRNA (small interfering RNA) screening, High-content cell imaging and analysis, Luminex xMAP technologies |
| UNMC Genomics Core | DNA Sequencing/Genotyping, Next Generation Sequencing, Whole genome sequencing |
| Mouse Genome Engineering Core | DNA Construct, Genotyping, Knockout Animals, Mouse Strain Rederivation, Transgenic Animals, Speed Congenics |
| Human Genetics Laboratory | Cytogenetics, FISH studies, Molecular genetics |
| Epigenomics | DNA Methylation Analysis |
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| Resource | Services |
| Cancer Research Informatics Office | Computational Tools for Studying Structure and Function. Development, maintenance, and support of data management systems and disease-specific registries and biobanks. |
| Computational Chemistry Core | Service for examining molecular structures and mechanisms in atomic detail and then providing a graphically rich analysis suitable for inclusion in publications and grants. |
| Bioinformatics and Systems Biology Facility | Biological Data Analysis, Development of Database/Application/Web Interfaces, Ingenuity Pathway Analysis, Whole Genome Mapping, RNAseq Mapping, Exome Sequencing Mapping, Next Generation Sequencing Analysis |
| Biomedical Informatics Education | Clinical Informatics, Information Standards (including medical ontologies & vocabularies) and Biomedical Informatics Education. Jim McClay, MD 402-559-35987 Jim Campbell, MD 402-559-7505 |
| Center for Collaboration on Research Design & Analysis (CCORDA) | Research Study Design, Biostatistics, Surveys and Statistical Analysis of Datasets |
| Electronic Health Record Data Access Core | Electronic Health Record Research, Feasibility Studies, Cross-Sectional Studies, Health Outcomes, Retrospective Data Analysis, Quality Improvement Projects, Public Health Research, Subject Recruitment Case Findings |
| Holland Computing Center |
High Performance Computing |
| Nebraska Biobank |
Deidentified Database of serum/plasma or DNA samples tied to electronic health information |
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| Resource | Services |
| Nanoimaging Core Facility | Combined Atomic Force Microscopy (AFM)/Raman supports nanomanipulations and characterization of mechanical, electrical, magnetic properties of samples. AFM capabilities include: topography imaging in air and liquid; force spectroscopy mode; nanoindentation providing elasticity measurements; nanolithography. |
| Nanomaterials Characterization Core Facility | Characterization of supramolecular polymer complexes by AUC. Polymer characterization by both Static (SLS) and Dynamic (DLS) Light Scattering. The facility offers: Inductively Coupled Plasma Mass Spectrometer, Surface Plasmon Resonance, Dynamic Light Scattering, Nanoparticle Tracking Analysis, Multimodal Laser Scanner, and Rodent Hematology & Blood Chemistry Analyzers |
| Nebraska Nanomedicine Production Plant | Resources to transition nanomedicines from preclinical screening to human clinical trials, including pre-production advisement and product preparation. |
PROTEOMICS AND SYSTEMS BIOLOGY |
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| Resource | Services |
| Preparative Ultracentrifuge | Separation of high-purity plasmid DNA, subcellular particles and virus isolation |
| Bioinformatics and Systems Biology Core | Discovery, Machine Learning Tools to Solve Biological Problems, Method Development, Data Mining and Knowledge Discovery |
| Cancer Research Informatics Office | Development, maintenance and support of data management systems and disease-specific registries and biobanks; Computational tools for studying structure and function of molecules |
| Computational Chemistry Core | Service for examining molecular structures and mechanisms in atomic detail and then providing a graphically rich analysis suitable for inclusion in publications and grants. |
| Circular Dichroism Spectrometer | Characterizes distinct 3-dimensional regions of proteins as they change shape in response to conditions that cause them to fold or unfold |
| Electron Paramagnetic Resonance (EPR Spectroscopy) | Free Radical Measurement |
| Mass Spectrometry and Proteomics | Mass Spectrometry including MALDI/TOF/TOF, LC-MS/MS such as LTQ Orbitrap, QTRAP and TripleTOF protein identification and quantification. |
| Molecular Interactions Core Facility | BIACORE is an optical biosensor that uses surface plasmon resonance (SPR) for real-time monitoring of macromolecular interactions without the need for labels. Affinity measurements, binding kinetics, active concentrations, binding specificity and epitope mapping. Target-ligand interactions |
| Nanomaterials Characterization Core Facility | Characterization of supramolecular polymer complexes by AUC. Polymer characterization by both Static (SLS) and Dynamic (DLS) Light Scattering. The facility offers: Inductively Coupled Plasma Mass Spectrometer, Surface Plasmon Resonance, Dynamic Light Scattering, Nanoparticle Tracking Analysis, Multimodal Laser Scanner, and Rodent Hematology & Blood Chemistry Analyzers |
| Nuclear Magnetic Resonance | Small molecule characterization, Structural determination of peptides, Drug discovery and Tissue analysis. |
| Eppley Cancer Center Molecular Biology and HTS Facility | High-throughput chemical, small molecule, and SiRNA (small interfering RNA) screening, High-content cell imaging and analysis, Luminex xMAP technologies |
| The Eppley Structural Biology Facility | Protein expression and purification for static (SLS) and dynamic light scattering(DLS), small angle X-ray scattering (SAXS), crystallization screening and optimization; and structure determination at the atomic level with X-Ray Cyrstallography. Specialized protein samples can also be made for data collection in the NMR core. |
| Translational Mouse Model Core | Provides humanized mouse models |