Cores and Services

Core Facilities

Jump to a Core Facility based on the categories listed below or use Control F to search by keyword

CATEGORIES

Animal Models, Behavior and Physiology
Bioimaging
Cell and Tissue Analysis
Clinical Research
Data Analysis and Statistics

Genomics
Informatics, Bioinformatics, & Biomedical Informatics
Proteomics and Systems Biology 
Nanomaterials & Technology 
Research Core Facilities on the UNL Campus


ANIMAL MODELS, BEHAVIOR AND PHYSIOLOGY

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Resource Services
Mouse Behavior Facility Metabolic Monitoring
Biological Irradiation Core Irradiation of small animals, tissue samples, and cultured cells
Comparative Medicine

Provides professional veterinary medical, husbandry and proposal review services to support animals used in research
Access e-Systems for Ordering Animals, Requesting Procedures, and compliance.  Research Support System (RSS)

Echocardiography Echocardiography
Electron Paramagnetic Resonance (EPR Spectroscopy) Free Radical Measurement
Experimental Irradiation Facility Gamma Irradiation Source
Hemodynamics Hemodynamics
Mouse Genome Engineering Core  DNA Construct, Genotyping, Knockout Animals, Mouse Strain Rederivation, Transgenic Animals, Speed Congenics
Translational Mouse Model Core Facility Provides humanized mouse models

BIOIMAGING

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Resource Services
Antibody Labeling Facility (ALF) Radiolabeling
Bioimaging Facility Non-human magnetic imaging and tomography (MRI, CT, SPECT)
UNMC Advanced Microscope Core Facility Confocal Laser Scanning Microscopy, Super Resolution Fluorescent Microscopy, Live Cell Imaging
PTI-Delta Scan Fluorimeter Real time detection and monitoring of intracellular calcium ion concentrations in living cells.
Electron Microscopy Facility Transmission and Scanning Electron Microscopy
IVIS Spectrum in vivo Imaging Core Facility IVIS optical imaging
Nanoimaging Core Facility Combined AFM/Raman supports nanomanipulations and characterization of mechanical, electrical, magnetic properties of samples.
Nanomaterials Characterization Core Facility Live animal molecular imaging using high-resolution anatomical X-rays.
Tissue Sciences Facility Human and Animal Tissue Pathology, digital Imaging, Slide Scanning, Automated Immunohistochemistry and Specialized Histology
Ultrasonic Imaging VEVO Ultrasonic Imaging
Radiology Molecular Imaging (PET) Human
MEG Center Magnetoencephalography (MEG) Human
Department of Internal Medicine, Cardiology Cardiovascular Ultrasound

CELL AND TISSUE ANALYSIS

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Resource Services
Biological Irradiation Core  Irradiation of small animals, tissue samples, and cultured cells
Electron Paramagnetic Resonance (EPR Spectroscopy) Free Radical Measurement
Tissue Sciences Facility Human and Animal Tissue Pathology, Digital Imaging, Slide Scanning, Image Analysis, Automated Immunohistochemistry and Specialized Histology 
Elutriation Core Facility Isolation of monocytes and lymphocytes from peripheral blood mononuclear cells (PBMCs)
Flow Cytometry Research Facility Flow Cytometry Services, Cell Separation
Electron Microscopy Research Facility Electron Microscopy/Confocal Microscopy
UNMC Advanced Microscope Core Facility Confocal Laser Scanning Microscopy, Super Resolution Fluorescent Microscopy, Live Cell Imaging
Eppley Cancer Center Molecular Biology and HTS Facility  High-throughput chemical, small molecule, and SiRNA (small interfering RNA) screening, High-content cell imaging and analysis, Luminex xMAP technologies

CLINICAL RESEARCH

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Resource Services
Biologics Production Facility GMP Facility for the manufacturing, production and modification of cells, tissues, cellular and tissue-derived products
Biomedical Informatics Facility Development, maintenance and support of data management systems and disease-specific registries and biobanks; Computational tools for studying structure and function of molecules
Center for Collaboration on Research Design and Analysis (CCORDA)              Biostatistics, Research Study Design, Surveys and Analysis
Center for Clinical and Translational Research Resources for Clinical Research
Center for Reducing Health Disparities Consultation on Study Design, Spanish translation services for and promotion and enrollment into research studies
Clinical Movement Analysis Laboratory  Equipment and resources to support human studies involving physical activity
Clinical Research Center  Outpatient clinical research facility provides clinical trial support from pre-proposal planning, to clinical services and training.  Clinic and laboratory space to conduct clinical trials and nurse coordinators and support staff for clinical trials.
Epigenomics DNA Methylation Analysis
Eppley Cancer Center Protocol Review and Monitoring System Data & Safety Monitoring
Electronic Health Record Data Access Core  Electronic health record access; feasibility, cross-sectional, health-outcomes, retrospective data analysis, quality improvement, registry creation, subject recruitment, public health research studies
Elutriation Core Facility Isolation of monocytes and lymphocytes from peripheral blood mononuclear cells (PBMCs).
Eppley Cancer Center Clinical Trials Office Centralized Protocol and Data Management Unit
Human Genetics Laboratory Cytogenetics, FISH studies, Molecular genetics
Institutional Review Board  (IRB) Assure Protection of all human subjects in research projects on the premises of the UNMC, NMC and UNO
Investigational Pharmacy   Custom pharmaceutical services for clinical and translational research.  Protocol assistance and design, Regulatory Oversight, Inventory Control, Documentation, Dispensing, Drug Information
Nebraska Biobank  Deidentified serum/plasma or DNA samples available for clinical/translational research projects
Nebraska Biomechanics Core Facility Gait analysis, muscular strength testing, endurance analysis, comprehensive balance analysis (on UNO campus)
Nebraska Nanomedicine Production Plant Resources to transition nanomedicines from preclinical screening to human clinical trials, including pre-production advisement and product preparation. 
UNMC Genomics Core Next Generation Sequencing , Whole genome sequencing, High Throughput Traditional Sequencing
Tissue Banking Core Facility Tissue for histologic, cytogenetic, immunohistochemical, and molecular analysis
Tissue Sciences Facility  Human and Animal Tissue Pathology, Digital Imaging, Slide Scanning, Image Analysis, Automated Immunohistochemistry and Specialized Histology 

DATA ANALYSIS AND STATISTICS

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Resource Services
Center for Collaboration on Research Design and Analysis (CCORDA) Biostatistics, Research Study Design Surveys and Analysis

GENOMICS

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Resource Services
Flow Cytometry Research Facility Flow Cytometry Services, Cell Separation
Eppley Cancer Center Molecular Biology and HTS Facility High-throughput chemical, small molecule, and SiRNA (small interfering RNA) screening, High-content cell imaging and analysis, Luminex xMAP technologies
UNMC Genomics Core DNA Sequencing/Genotyping, Next Generation Sequencing, Whole genome sequencing
Mouse Genome Engineering Core  DNA Construct, Genotyping, Knockout Animals, Mouse Strain Rederivation, Transgenic Animals, Speed Congenics
Human Genetics Laboratory Cytogenetics, FISH studies, Molecular genetics
Epigenomics DNA Methylation Analysis


BIOINFORMATICS & BIOMEDICAL INFORMATICS


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Resource Services
Biomedical Informatics & Molecular Modeling Facility Computational Tools for Studying Structure and Function.  Development, maintenance and support of data management systems and disease-specific registries and biobanks.
Bioinformatics and Systems Biology Facility Biological Data Analysis, Development of Database/Application/Web Interfaces, Ingenuity Pathway Analysis, Whole Genome Mapping, RNAseq Mapping, Exome Sequencing Mapping, Next Generation Sequencing Analysis
Biomedical Informatics Education Clinical Informatics, Information Standards (including medical ontologies & vocabularies) and Biomedical Informatics Education.
Jim McClay, MD 402-559-35987
Jim Campbell, MD 402-559-7505
Center for Collaboration on Research Design & Analysis (CCORDA) Research Study Design, Biostatistics, Surveys and Statistical Analysis of Datasets
Electronic Health Record Data Access Core Electronic Health Record Research, Feasibility Studies, Cross-Sectional Studies, Health Outcomes, Retrospective Data Analysis, Quality Improvement Projects, Public Health Research, Subject Recruitment Case Findings
Holland Computing Center

High Performance Computing
David Swanson, PhD 402-572-5006

Nebraska Biobank

Deidentified Database of serum/plasma or DNA samples tied to electronic health information

 

NANOMATERIALS, NANOMEDICINE, & NANOTECHNOLOGIES

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Resource Services
Nanoimaging Core Facility Combined Atomic Force Microscopy (AFM)/Raman supports nanomanipulations and characterization of mechanical, electrical, magnetic properties of samples.  AFM capabilities include: topography imaging in air and liquid; force spectroscopy mode; nanoindentation providing elasticity measurements; nanolithography.  
Nanomaterials Characterization Core Facility Characterization of supramolecular polymer complexes by AUC.  Polymer characterization by both Static (SLS) and Dynamic (DLS) Light Scattering.
Nebraska Nanomedicine Production Plant Resources to transition nanomedicines from preclinical screening to human clinical trials, including pre-production advisement and product preparation. 

PROTEOMICS AND SYSTEMS BIOLOGY

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Resource Services
Preparative Ultracentrifuge Separation of high-purity plasmid DNA, subcellular particles and virus isolation
Bioinformatics and Systems Biology Core Discovery, Machine Learning Tools to Solve Biological Problems, Method Development, Data Mining and Knowledge Discovery
Biomedical Informatics Facility Development, maintenance and support of data management systems and disease-specific registries and biobanks; Computational tools for studying structure and function of molecules
Circular Dichroism Spectrometer Characterizes distinct 3-dimensional regions of proteins as they change shape in response to conditions that cause them to fold or unfold
Electron Paramagnetic Resonance (EPR Spectroscopy) Free Radical Measurement
Mass Spectrometry and Proteomics Mass Spectrometry including MALDI/TOF/TOF, LC-MS/MS such as LTQ Orbitrap, QTRAP and TripleTOF protein identification and quantification. 
Molecular Interactions Core Facility BIACORE is an optical biosensor that uses surface plasmon resonance (SPR) for real-time monitoring of macromolecular interactions without the need for labels.  Affinity measurements, binding kinetics, active concentrations, binding specificity and epitope mapping.  Target-ligand interactions  
Nanomaterials Characterization Core Facility Characterization of supramolecular polymer complexes by AUC.  Polymer characterization by both Static (SLS) and Dynamic (DLS) Light Scattering.
Nuclear Magnetic Resonance Small molecule characterization, Structural determination of peptides, Drug discovery and Tissue analysis.
Protein Structure Facility Amino Acid Analysis, Protein Sequencing, Peptide Separation
Eppley Cancer Center Molecular Biology and HTS Facility High-throughput chemical, small molecule, and SiRNA (small interfering RNA) screening, High-content cell imaging and analysis, Luminex xMAP technologies
The Eppley Structural Biology Facility Protein expression and purification for static (SLS) and dynamic light scattering(DLS), small angle X-ray scattering (SAXS), crystallization screening and optimization; and structure determination at the atomic level with X-Ray Cyrstallography.  Specialized protein samples can also be made for data collection in the NMR core.
Translational Mouse Model Core Provides humanized mouse models