Dr. Band also holds courtesy appointments in the UNMC departments of Biochemistry and Molecular Biology; Genetics, Cell Biology and Anatomy; and Pathology and Microbiology.

Research Interests

Our laboratory focuses on two major topics, both geared towards understanding and potentially targeting the intracellular traffic of cell surface receptors coupled to activation of tyrosine kinase signaling:

1. The CBL-family ubiquitin ligases, which provide an essential mechanism of negative regulation of receptor and non-receptor tyrosine kinases through ubiquitin-dependent proteasomal and lysosomal degradation.
2. Members of the EHD family of membrane-activated ATPase proteins, which control subcellular traffic of cell surface receptors.

We use mouse genetic models, cell biology, biochemistry, and molecular biology approaches to investigate the roles of the CBL and EHD protein families in physiological function and oncogenesis in epithelial (mammary, prostate, ovarian, intestinal) and hematopoietic systems. Recent interests of the laboratory focus on the role of the above pathways in cancers and avenues to target these pathways.