Assistant Professor, Eppley Institute
Tel: 402-559-6218 (Office)
Genetic and epigenetic regulation of prostate cancer metastasis.
Summary of Research:
Our lab studies the genetic and epigenetic regulation of prostate cancer metastasis. We investigate adaptive cell fate decisions and signal transduction networks utilized by cancer cells during the metastatic cascade. The main areas of interest are: transcriptional regulation of indolent to metastatic switch, decoding cellular fitness phenotypes leading to therapy resistance, and molecular mechanisms of whole genome duplication in cancer. We combine mouse genetics, whole organ imaging, cell biology, and biochemical techniques to integrate and interpret how cancer cells adapt to selective pressures and the dynamic ecosystems arising during malignant transformation and metastasis. These mechanistic insights will provide a better grasp on the genetic dependencies of metastatic cells and boost the development of novel therapeutic approaches towards a lethal form of disease.
The Mathew lab actively advocates for diversity, equity and inclusion in the biomedical sciences. We aim for a collegiate atmosphere conducive to research and training in science.