Professor, Eppley InstituteCourtesy Appointment - Department of Genetics, Cell Biology and Anatomy;
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Research Interests
Our research interests are focused on the discovery and development of small molecule inhibitors to perturb disease relevant biomolecules. We are also interested in using these small molecule inhibitors to understand the role of the disease relevant biomolecules in signal transduction. Small molecule inhibitors for these studies are identified and developed from a variety of sources, which include screening chemical libraries, natural products and conformationally constrained mimics. Synthetic chemistry spearheads our research program, however, biology and computational methods are used synergistically in our quest for a better comprehension of the cellular events contiguous to disease relevant proteins.
Targeting the phosphoprotein binding site on BRCT(BRCA1) / Cbl (TKB)
Assay development and high throughput screening
Methods development, synthesis of focused libraries and natural product syntheses
On the path from bench to bedside – Studies in mouse models
Group Pictures
Spring 2024
Spring 2021
Summer 2019
Summer 2019
Summer 2018
Fall 2017
Winter 2016
Summer 2016
Spring 2016
Summer 2015
Spring 2015
Winter 2014
Summer 2013