Program for Thoracic Organ Preservation and Rejuvenation

UNMC is unique as the sole regional center that performs all solid organ transplantation. Currently a large gap exists nationally between the availability of organs for transplant and the number of patients in need of transplant. Additionally, the early function of the transplanted organ is critical to a successful transplant.

The UNMC program for organ preservation and rejuvenation embraces the philosophy that we can both increase the utilization of solid organs for transplant, and enhance the performance of those organs through, 1) An improved understanding of the mechanism of donor organ injury,

2) Strategies to reduce and counter donor organ injury

3) Strategies to increase organ acceptance from potential donors. The program has both clinical and research components with involvement in several clinical registries, trials and research protocols.

Program Director:

Marian Urban MD, PhD

Our team:

Kim F. Duncan, MD, FACS

Aleem Siddique, MBBS, FACS

John Y. Um, MD, FACS

Anthony W. Castleberry, MD, MMCi

Nicholas W. Markin, MD, FASE

M. Megan Chacon, MD

Lance Fristoe

Trials

Expand II trial for OCS use in lung transplantation

https://www.clinicaltrials.gov/ct2/show/NCT03343535

TOP registry for OCS use lung transplantation

https://clinicaltrials.gov/ct2/show/NCT03639025

OCS DCD trial for OCS use in heart transplantation

Donors After Circulatory Death Heart Trial - Full Text View - ClinicalTrials.gov

OCS DCD registry for OCS use in heart transplantation

Donors After Circulatory Death Heart Trial - Full Text View - ClinicalTrials.gov

DCD-NRP trial

Safety and Effectiveness of NRP for DCD Heart Transplantation - Full Text View - ClinicalTrials.gov

News and Articles

https://www.wowt.com/2021/01/21/first-of-its-kind-heart-transplant-gives-nebraska-man-a-second-chance-at-life/

https://kfab.iheart.com/content/2021-01-20-procedure-marks-milestone-for-heart-transplants-in-nebraska/

https://omaha.com/lifestyles/health-med-fit/its-going-to-save-lives-new-type-of-heart-transplant-performed-in-nebraska/article_5f9eb0bc-5bfb-11eb-bcfe-5b79a738b200.html

https://www.beckershospitalreview.com/cardiology/nebraska-medical-center-latest-in-us-to-complete-heart-transplant-using-novel-technique.html