Xuanhua Peter Xie, PhD
Assistant Professor, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Research Focus: tumor initiation, recurrence, and metastasis
Research focus: Cancer stem cell, Brain tumor, Central nervous system development, Stem cell maintenance, Therapy resistance, Tumor recurrence, Tumor metastasis
Dr. Xie’s research focuses on tumor initiation, recurrence, and metastasis. Using brain tumors as a model, his lab studies tumor heterogeneity and cell types responsible for therapy resistance and tumor recurrence. The specific areas include:
- Elucidate the role of F3 in neural and cancer stem cells
- Determine the downstream/upstream regulators of neural and cancer stem cells
- Identify and characterize drugs targeting cancer stem cells
- Examine Niche components crucial for cancer stem cells and brain metastases
Education
- Post-doc, Memorial Sloan Kettering Cancer Center, New York, NY
- Post-doc, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX
- PhD, The University of Texas at Austin, Austin, TX
- MS, Fudan University, Shanghai, China
Research
- Regulation of neural stem cells and targeting of cancer stem cells
- Tumor heterogeneity and combination therapy
Selected Publications
- High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging. Xie X, Laks D, Sun DC, Poran A, Laughney AM, Wang ZL, Sam J, Belenguer G, Fariñas I, Elemento O, Zhou XP, Parada LF, Proc Natl Acad Sci U S A. 2020. PMID: 33229571
- Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression. Sun DC, Xie X, Wang ZL, Sait SF, Iyer SV, Chen YJ, Brown R, Laks D, Chipman M, Parada LF. Cell Stem Cell. 2021 May 11:S1934-5909(21)00187-9. doi: 10.1016/j.stem.2021.04.029.
- Quiescent human glioblastoma stem cells drive tumor initiation, expansion, and recurrence following chemotherapy. *Xie X, Laks D, Sun DC, Ganbold M, Wang ZL, Pedraza AM, Bale T, Tabar V, Brennan C, Zhou XP, *Parada LF. Dev Cell. 2022 Jan 10;57(1):32-46.e8. doi: 10.1016/j.devcel.2021.12.007. *Corresponding author
- Glioblastoma functional heterogeneity and enrichment of cancer stem cells with tumor recurrence. *Xie XP, Ganbold M, Li J, Lien M, Chipman ME, Wang T, Jayewickreme CD, Pedraza AM, Bale T, Tabar V, Brennan C, Sun DC, Sharma R, *Parada LF. Neuron. 2024 *Corresponding author
Recognition
- Basic Research Fellowship from American Brain Tumor Association, 2013-2015
- Poster Award at Anderson Center for Cancer Research Symposium 2015