Muhammad Zahid, PhD

Research Assistant Professor

Department of Environmental, Agricultural and Occupational Health
University of Nebraska Medical Center
College of Public Health

Professional Summary

• Jan 2011-present Research Assistant Professor, Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.
• Nov 2010-Jan 2011 Research Assistant Professor, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
• Dec 2008-Nov 2010 Senior Research Associate, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
• Dec 2005-Dec 2008 Research Associate, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
• March 2002-Dec 2005 Postdoctoral Research Associate, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
• Dec 2000-March 2002 Post Doctoral Research Associate, Department of Chemistry, ZheiJiang University, Hangzhou, China.
• Jan 2000-Dec 2000 Research Assistant, International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
• Jan 1995-Dec 1999 Research Fellow, International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

Education

• PhD Organic chemistry, University of the Punjab, Lahore, Pakistan, 2002
• MSc Analytical chemistry, University of the Punjab, Lahore, Pakistan, 1994
• BSc Chemistry, Physics, Mathematics, Karachi University, Karachi, Pakistan, 1990

Research Interests

Inter disciplinary chemical and biochemical approaches and techniques to focus on the etiology of human cancers initiation mechanism, leukemia and Parkinson’s disease with major focus:

• Understand the mechanism of cancer initiating steps by natural and synthetic estrogens.
• Development of chemo preventive agent to block breast and prostate cancers initiating steps.
• Development of biomarkers by applying target/profile oriented metabolomic methods.
• Modulation of metabolic profile by using nutritional antioxidant and phytochemicals.

Selected Publications

• Zahid, M., Kohli, E., Saeed, M., Rogan, E. and Cavalieri, E. The greater reactivity of estradiol-3,4-quinone versus estradiol-2,3-quinone with DNA in the formation of depurinating adducts. Implications for tumor-initiating activity. Chem. Res. Toxicol., 19: 164-172, 2006.
• Zahid, M., Saeed, M., Lu, F., Gaikwad, N., Rogan, E. and Cavalieri, E.L. Inhibition of catechol-O-methyltransferase increases estrogen DNA-adduct formation. Free. Radic. Biol. Med., 43: 1534-1540, 2007. PMCID: PMC2096412
• Zahid, M., Gaikwad, N.W., Ali, M.F., Lu, F., Saeed, M., Yang, L., Rogan, E.G. and Cavalieri, E.L. Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol. Free Radic. Biol. Med., 45: 136-145, 2008. PMCID: PMC2494714
• Lu, F., Zahid, M., Wang, C., Saeed, M., Cavalieri, E. and Rogan, E. Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells. Cancer Prev. Res., 1: 135-145, 2008.
• Zahid, M., Saeed, M., Rogan, E.G. and Cavalieri, E.L. Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease. Free Radic. Biol. Med., 48: 318-324, 2010. PMCID: PMC2818485
• Zahid, M., Saeed, M., Beseler, C., Rogan, E.G. and Cavalieri, E.L. Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells. Free Radic. Biol. Med., 50: 78-85, 2011.
• Zahid, M., Saeed, M., Yang, L., Beseler, C., Rogan, E. and Cavalieri, E. Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson’s disease. IUBMB Life, 63: 1087-1093, 2011.
• Yang, L., Zahid, M., Liao, Y., Rogan, E.G., Cavalieri, E.L., Davidson, N.E., Yager, J.D., Visvanathan, K., Groopman, J.D and Kensler, T.W. Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells. Carcinogenesis, 34: 2587-2592, 2013.
• Zahid, M., Goldner, W., Beseler, C.L., Rogan, E.G. and Cavalieri, E.L. Unbalanced estrogen metabolism in thyroid cancer. Int. J. Cancer, 133: 2642-2649, 2013.
• Zahid, M., Beseler, C.L., Hall, J.B., LeVan, T., Cavalieri, E.L. and Rogan, E.G. Unbalanced estrogen metabolism in ovarian cancer. Int. J. Cancer, doi: 10.1002/ijc.28565, 2013.

Professional Affiliations

• American Association for Cancer Research (AACR) (2002-2008)
• American Society of Pharmacognosy (Since 2007)
• Pakistan Chemical Society (Since 1994)

Ad-hoc Reviewer

• Public Library of Science (PLoS)
• Journal of Chemical Society of Pakistan
• Cancer Prevention Research