Alyssa C. Bouska, PhD | Pathology, Microbiology, and Immunology

Department Affiliations
Instructor

Interests
Research project: Identifying genetic abnormalities associated with B-cell lymphomas and Peripheral T-cell lymphoma using gne expression SNP arrays, Next Generation sequencing and gnee expression microarray data.

Education
BSc (Magna Cum Laude), Biology, Creighton University, Omaha, NE 2002
PhD, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 2008

Notable Publications
Song JY, Egan C, Bouska AC, et al. Genomic characterization of diffuse large B-cell lymphoma transformation of nodular lymphocyte-predominant Hodgkin lymphoma. Leukemia 2020;34(8):2238-2242. (In eng). DOI: 10.1038/s41375-020-0739-7.

Carras S, Chartoire D, Mareschal S, et al. Among authors: Bouska A. Chronic T cell receptor stimulation unmasks NK receptor signaling in peripheral T cell lymphomas via epigenetic reprogramming. J Clin Invest2021;131(13) (In eng). DOI: 10.1172/jci139675.

Chapman JR, Bouska AC, Zhang W, Alderuccio JP, Lossos IS, Rimsza LM, Maguire A, Yi S, Chan WC,Vega F, Song JY. EBV-positive HIV-associated diffuse large B cell lymphomas are characterized by JAK/STAT (STAT3) pathway mutations and unique clinicopathologic features. Br J Haematol2021;194(5):870-878. (In eng). DOI: 10.1111/bjh.17708.

Dong G, Li Y, Lee L, Liu X, Shi Y, Liu X, Bouska A, Gong Q, Kong L, Wang J, Lou CH, McKeithan TW, Iqbal J, Chan WC. Genetic manipulation of primary human natural killer cells to investigate the functionaland oncogenic roles of PRDM1. Haematologica 2021;106(9):2427-2438. (In eng). DOI: 10.3324/haematol.2020.254276.

Lone W*, Bouska A*, Sharma S*, et al. Genome-Wide miRNA Expression Profiling of Molecular Subgroups of Peripheral T-cell Lymphoma. Clin Cancer Res 2021;27(21):6039-6053. (In eng). DOI: 10.1158/1078-0432.Ccr-21-0573.

Wang C, Althof PA, Bi C, Zhang W, Bouska AC, Tian T, Zhang X, Jiang N, Yu G, Cheng H, Iqbal J, Vose JM, Sanmann JN, Fu K. A novel MYC-non-IG fusion in refractory diffuse large B-cell lymphoma. Br J Haematol 2021;193(5):1001-1004. (In eng). DOI: 10.1111/bjh.17255.

Dong G, Liu X, Wang L, Yin W, Bouska A, et al. Genomic profiling identifies distinct genetic subtypes in extra-nodal natural killer/T-cell lymphoma. Leukemia 2022 (In eng). DOI: 10.1038/s41375-022-01623-z.

Herek TA, Bouska A, et al.

DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T-cells in PTCL-NOS. Blood 2022 (In eng). DOI: 10.1182/blood.2021015019.

Ma MCJ, Tadros S, Bouska A, et al. Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma. Haematologica 2022;107(3):690-701. (In eng). DOI: 10.3324/haematol.2020.274258.

Amador C*, Bouska A*, Wright G, et al. Gene Expression Signatures for the Accurate Diagnosis of Peripheral T-Cell Lymphoma Entities in the Routine Clinical Practice. Journal of Clinical Oncology, 2022 Dec 20;40(36):4261-4275