Iman M. Ahmad, PhD

Associate Professor

Department of Clinical, Diagnostic, & Therapeutic Sciences     Iman Ahmad
University of Nebraska Medical Center
984545 Nebraska Medical Center
Omaha, NE 68198-4545
402-559-6911
Email

Academic Appointments:
Associate Professor, 2019
Assistant Professor, 2013

Degrees/Certifications:
B.Sc., Diagnostic Radiologic Technology, Kuwait University, Kuwait City, Kuwait, 1989
PhD, Free Radicals and Radiation Biology, University of Iowa, Iowa City, Iowa, USA, 2003

Primary Teaching Responsibilities:
MITS 414R Health Physics
MITS 438N Advanced Radiation Biology
MITS 413R Radiographic Contrast Media
MITS 313R Radiologic Technology II
MITS 350R Radiographic Pathology I
MITS 355R Radiographic Pathology II

Research Experience:
Visiting Scientist: University of Cincinnati (July-Sept. 2005)
Working on the oxidative stress induced by pyocyanin in A549 and HBE cells.
The study includes the study of expression of Glutathione (total and mitochondrial), HO-1, Thioredoxin, and HIF-1alpha.

Visiting Scientist: University of Iowa (June-Aug. 2006)
Working on 2-deoxyglucose-induced sensitization to p53 induced cell death in prostate cancer cells.

Visiting Scientist: University of Iowa (June-Aug. 2007)
Working on radiation therapy, metabolic oxidative stress, and cancer biology project.

Visiting Scientist: University of Iowa (June-Aug. 2008)
Working on cancer therapy related projects that involve imaging responses to 2-deoxyglucose-induced radiosensitization and radiation-induced genomic instability.

Research Responsibilities:
Conduct research in ongoing redox biology studies using state-of-the art techniques to measure levels of antioxidants and oxidants in biological samples; involved in designing and optimizing experimental protocols; and writing collaborative research grants.

Publications (last 5 years):
Ahmad IM, Dafferner AJ, Mehla K, O'Connell KA, Britigan BE, Hollingsworth MA, Abdalla MY. Heme Oxygenase-1 Inhibition potentiates the effects of nab-paclitaxel-gemcitabine and modulates the tumor microenvironment in Pancreatic Ductal Adenocarcinoma. Cancers. 13(9): 2264. 2021. https://doi.org/10.3390/cancers13092264

Moore TA, Samson K, Ahmad IM, Pickler RH, Zimmerman MC. Oxidative Stress in Pregnant Women Between 12–20 Weeks Gestation and Preterm Birth. Nursing Research. 69(3): 244-248. 2020. https://doi.org/10.1097/nnr.0000000000000414.

Ahmad IM, Zimmerman MC, Moore TA. Oxidative Stress in Early Pregnancy and the Risk of Preeclampsia. Pregnancy Hypertension. 18: 99-102. 2019. https://doi.org/10.1016/j.preghy.2019.09.014.

Moore TA, Ahmad IM, Schmid KK, Berger AM, Ruiz RJ, Pickler RH, Zimmerman MC. Oxidative Stress Levels Throughout Pregnancy, At Birth, and In The Neonate. Biological Research for Nursing. 21(5): 485-494. 2019. https://doi.org/10.1177/1099800419858670.

Ahmad IM. Reply to “Comment on Ahmad, I.M. et al. Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters. Antioxidants, 2019, 8, 12.” Antioxidants. 8(2) pii: E43, 2019. http://dx.doi.org/10.3390/antiox8020043

Abdalla MY, Ahmad IM, Rachagani S, Banerjee K, Thompson CM, Maurer HC, Olive KP, Bailey KL, Britigan BE, Kumar S. Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition. Transl Res. 2019 Jan 4. pii: S1931-5244(19)30001-5. doi: 10.1016/j.trsl.2018.12.008. [Epub ahead of print]. PMID: 30653942

Ahmad IM, Abdalla MY, Moore TA, Bartenhagen L, Case AJ, Zimmerman MC. Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters. Antioxidants 8, 12, 2019. Open access: http://www.mdpi.com/2076-3921/8/1/12/pdf

Moore TA, Ahmad IM, Zimmerman MC. Oxidative Stress and Preterm Birth: An Integrative Review. Biological Research For Nursing 20(5): 497-512, 2018.

Kalen AL, Ahmad IM, Abdalla MY, O’Malley YQ, Goswami PC, Sarsour EH. MnSOD and Cyclin B1 Coordinate a Mito-Checkpoint during Cell Cycle Response to Oxidative Stress. Antioxidants, 6, 92; 2017 doi:10.3390/antiox6040092 PDF

Dickinson JD, Sweeter JM, Warren KJ, Ahmad IM, De Deken X, Zimmerman MC, Brody SL. Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation. Redox Biol. 2017 Sep 22;14:272-284. doi: 10.1016/j.redox.2017.09.013. [Epub ahead of print] PMID: 28982074 Free PMC Article

Bajbouj K, Shafarin J, Abdalla MY, Ahmad IM, Hamad M. Estrogen-induced disruption of intracellular iron metabolism leads to oxidative stress, membrane damage, and cell cycle arrest in MCF-7 cells. Tumor Biology, Oct: 1-12, 2017. DOI: 10.1177/1010428317726184 PDF

Ahmad IM, Temme JB, Abdalla MY, Zimmerman MC. Redox status in workers occupationally exposed to long-term low levels of ionizing radiation: A pilot study. Redox Rep. 2016 Jan 28. [Epub]

Saraswathi V, Ganesan M, Perriotte-Olson C, Manickam DS, Westwood RA, Zimmerman MC, Ahmad IM, Desouza CV, Kabanov AV. Nanoformulated copper/zinc superoxide dismutase attenuates vascular cell activation and aortic inflammation in obesity. Biochem Biophys Res Commun. 2016 Jan 15;469(3):495-500. doi: 10.1016/j.bbrc.2015.12.027. Epub 2015 Dec 12.

Case AJ, Agraz D, Ahmad IM, Zimmerman MC. Low-Dose Aronia melanocarpa Concentrate Attenuates Paraquat-Induced Neurotoxicity. Oxid Med Cell Longev. 2016;2016:5296271. doi: 10.1155/2016/5296271. Epub 2015 Dec 6.

Mustafa EH, Mahmoud HT, Al-Hudhud MY, Abdalla MY, Ahmad IM, Yasin SR, Elkarmi AZ, Tahtamouni LH. 2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells. Asian Pac J Cancer Prev, 16 (8), 3213-3222, 2015.

Abdalla MY, Ahmad IM, Switzer B, Britigan BE. (2015) Induction ofhemeoxygenase-1 contributes to survival of Myco-bacterium abscessus in human macrophages-like THP-1 cells. Redox Biology. 4:328-339.

Tayyem RF*, Ahmad IM*, Shehadah I, Bani-Hani K, Al-Jaberi T , Al-Nusairr M. Glutathione, Vitamin D and Antioxidant Status in the Blood of Patients with Colorectal Cancer: A Pilot Study. (2015) Pakistan Journal of Nutrition. 14 (1): 13-17.

Savalia K, Manickam DS, Rosenbaugh EG, Tian J, Ahmad IM, Kabanov AV, Zimmerman MC. Neuronal uptake of nanoformulated superoxide dismutase and attenuation of angiotensin II-dependent hypertension after central administration. Free Radical Biology and Medicine. 73 (2014) 299-307.

Active Grant Support
Co-Investigator, Heme Oxygenase-1 Inhibition Sensitize Pancreatic Cancer to Gemcitabine Therapy Under Hypoxia, funded by Fred & Pamela Buffett Cancer Center, Jan 15, 2019 (MY Abdalla, PI)

Invited Presentations
"Oxidative stress, DNA damage and Inflammation as biomarkers of radiotoxicity in radiation exposed healthcare workers - the side effects of radiotherapy on cancer patients,” at the 3rd ISANH Middle East Antioxidants World Congress on May 2-3, 2018.

Honors and Awards
Innovative Scholarship Award, CAHP, UNMC (2019)