Recent AMCF Publications

Bhatia R, Siddiqui JA, Ganguly K, Thompson CM, Cannon A, Aithal A, Perumal N, Maurya SK, Li X, Cox JL, Gurumurthy CB, Rachagani S, Jain M, Nasser MW, Batra SK, Kumar S. Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis. Oncogene. 2023 Jan 9. doi: 10.1038/s41388-022-02587-1. Epub ahead of print. PMID: 36624189. 

 

Bhatia R, Thompson CM, Clement EJ, Ganguly K, Cox JL, Rauth S, Siddiqui JA, Mashiana SS, Jain M, Wyatt TA, Mashiana HS, Singh S, Woods NT, Kharbanda KK, Batra SK, Kumar S. Malondialdehyde-Acetaldehyde Extracellular Matrix Protein Adducts Attenuate Unfolded Protein Response During Alcohol and Smoking-Induced Pancreatitis. Gastroenterology. 2022 Oct;163(4):1064-1078.e10. doi: 10.1053/j.gastro.2022.06.071. Epub 2022 Jul 3. PMID: 35788346; PMCID: PMC9796922. 

 

Dutta S, Polavaram NS, Islam R, Bhattacharya S, Bodas S, Mayr T, Roy S, Albala SAY, Toma MI, Darehshouri A, Borkowetz A, Conrad S, Fuessel S, Wirth M, Baretton GB, Hofbauer LC, Ghosh P, Pienta KJ, Klinkebiel DL, Batra SK, Muders MH, Datta K. Neuropilin-2 regulates androgen-receptor transcriptional activity in advanced prostate cancer. Oncogene. 2022 Jul;41(30):3747-3760. doi: 10.1038/s41388-022-02382-y. Epub 2022 Jun 27. PMID: 35754042. 

 

Ganguly K, Bhatia R, Rauth S, Kisling A, Atri P, Thompson C, Vengoji R, Ram Krishn S, Shinde D, Thomas V, Kaur S, Mallya K, Cox JL, Kumar S, Batra SK. Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance. Gastroenterology. 2022 Jan;162(1):253-268.e13. doi: 10.1053/j.gastro.2021.09.017. Epub 2021 Sep 14. PMID: 34534538; PMCID: PMC8678212. 

 

Gautam SK, Dalal V, Sajja BR, Gupta S, Gulati M, Dwivedi NV, Aithal A, Cox JL, Rachagani S, Liu Y, Chung V, Salgia R, Batra SK, Jain M. Endothelin-axis antagonism enhances tumor perfusion in pancreatic cancer. Cancer Lett. 2022 Sep 28;544:215801. doi: 10.1016/j.canlet.2022.215801. Epub 2022 Jun 19. PMID: 35732216. 

 

Islam R, Mishra J, Polavaram NS, Bhattacharya S, Hong Z, Bodas S, Sharma S, Bouska A, Gilbreath T, Said AM, Smith LM, Teply BA, Muders MH, Batra SK, Datta K, Dutta S. Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance. Cell Rep. 2022 Jul 19;40(3):111097. doi: 10.1016/j.celrep.2022.111097. PMID: 35858551; PMCID: PMC9362995. 

 

Lakshmanan I, Marimuthu S, Chaudhary S, Seshacharyulu P, Rachagani S, Muniyan S, Chirravuri-Venkata R, Atri P, Rauth S, Nimmakayala RK, Siddiqui JA, Gautam SK, Shah A, Natarajan G, Parte S, Bhyravbhatla N, Mallya K, Haridas D, Talmon GA, Smith LM, Kumar S, Ganti AK, Jain M, Ponnusamy MP, Batra SK. Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma. Oncogene. 2022 Nov;41(48):5147-5159. doi: 10.1038/s41388-022-02493-6. Epub 2022 Oct 21. PMID: 36271032. 

 

Leon F, Seshacharyulu P, Nimmakayala RK, Chugh S, Karmakar S, Nallasamy P, Vengoji R, Rachagani S, Cox JL, Mallya K, Batra SK, Ponnusamy MP. Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer. Oncogene. 2022 Jan;41(1):57-71. doi: 10.1038/s41388-021-02047-2. Epub 2021 Oct 21. PMID: 34675409; PMCID: PMC8727507. 

 

Machhi J, Yeapuri P, Markovic M, Patel M, Yan W, Lu Y, Cohen JD, Hasan M, Abdelmoaty MM, Zhou Y, Xiong H, Wang X, Mosley RL, Gendelman HE, Kevadiya BD. Europium-Doped Cerium Oxide Nanoparticles for Microglial Amyloid Beta Clearance and Homeostasis. ACS Chem Neurosci. 2022 Apr 20;13(8):1232-1244. doi: 10.1021/acschemneuro.1c00847. Epub 2022 Mar 21. PMID: 35312284; PMCID: PMC9227977. 

 

Marimuthu S, Lakshmanan I, Muniyan S, Gautam SK, Nimmakayala RK, Rauth S, Atri P, Shah A, Bhyravbhatla N, Mallya K, Grandgenett PM, Hollingsworth MA, Datta K, Jain M, Ponnusamy MP, Batra SK. MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion. Mol Cancer Res. 2022 Aug 5;20(8):1208-1221. doi: 10.1158/1541-7786.MCR-21-0888. PMID: 35533267; PMCID: PMC9635595. 

 

Mir S, Golden BDO, Griess BJ, Vengoji R, Tom E, Kosmacek EA, Oberley-Deegan RE, Talmon GA, Band V, Teoh-Fitzgerald ML. Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction. Breast Cancer Res. 2022 Jul 14;24(1):48. doi: 10.1186/s13058-022-01548-6. PMID: 35836253; PMCID: PMC9281082. 

 

Mughees M, Kaushal JB, Sharma G, Wajid S, Batra SK, Siddiqui JA. Chemokines and cytokines: Axis and allies in prostate cancer pathogenesis. Semin Cancer Biol. 2022 Nov;86(Pt 3):497-512. doi: 10.1016/j.semcancer.2022.02.017. Epub 2022 Feb 16. PMID: 35181473; PMCID: PMC9793433. 

 

Nimmakayala RK, Ogunleye AO, Parte S, Krishna Kumar N, Raut P, Varadharaj V, Perumal NK, Nallasamy P, Rauth S, Cox JL, Lele SM, Batra SK, Ponnusamy MP. PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer. Cell Death Dis. 2022 Oct 1;13(10):839. doi: 10.1038/s41419-022-05258-x. PMID: 36180487; PMCID: PMC9525575. 

 

Peng ZH, Jogdeo CM, Li J, Xie Y, Wang Y, Sheinin YM, Kopeček J, Oupický D. Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model. Pharmaceutics. 2022 Aug 18;14(8):1725. doi: 10.3390/pharmaceutics14081725. PMID: 36015351; PMCID: PMC9416753. 

 

Phillips AJ, Lobl MB, Hafeji YA, Safranek HR, Mohr AM, Mott JL. Glycosylation of FGFR4 in cholangiocarcinoma regulates receptor processing and cancer signaling. J Cell Biochem. 2022 Mar;123(3):568-580. doi: 10.1002/jcb.30204. Epub 2022 Jan 4. PMID: 34981854; PMCID: PMC8940645. 

 

Pothuraju R, Pai P, Chaudhary S, Siddiqui JA, Cox JL, Kaur S, Rachagani S, Roy HK, Bouvet M, Batra SK. Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer. Aging (Albany NY). 2022 Mar 7;14(5):2025-2046. doi: 10.18632/aging.203935. Epub 2022 Mar 7. PMID: 35255004; PMCID: PMC8954958. 

 

Seshacharyulu P, Halder S, Nimmakayala R, Rachagani S, Chaudhary S, Atri P, Chirravuri-Venkata R, Ouellette MM, Carmicheal J, Gautam SK, Vengoji R, Wang S, Li S, Smith L, Talmon GA, Klute K, Ly Q, Reames BN, Grem JL, Berim L, Padussis JC, Kaur S, Kumar S, Ponnusamy MP, Jain M, Lin C, Batra SK. Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling. EBioMedicine. 2022 Jan;75:103772. doi: 10.1016/j.ebiom.2021.103772. Epub 2021 Dec 28. PMID: 34971971; PMCID: PMC8718746. 

 

Zeng Y, Yin L, Zhou J, Zeng R, Xiao Y, Black AR, Hu T, Singh PK, Yin F, Batra SK, Yu F, Chen Y, Dong J. MARK2 regulates chemotherapeutic responses through class IIa HDAC-YAP axis in pancreatic cancer. Oncogene. 2022 Jul;41(31):3859-3875. doi: 10.1038/s41388-022-02399-3. Epub 2022 Jul 2. PMID: 35780183; PMCID: PMC9339507. 

 

Zhang C, Atri P, Nallasamy P, Parte S, Rauth S, Nimmakayala RK, Marimuthu S, Chirravuri-Venkata R, Bhatia R, Halder S, Shah A, Cox JL, Smith L, Kumar S, Foster JM, Kukreja RC, Seshacharyulu P, Ponnusamy MP, Batra SK. Small molecule inhibitor against onco-mucins disrupts Src/FosL1 axis to enhance gemcitabine efficacy in pancreatic ductal adenocarcinoma. Cancer Lett. 2022 Sep 19;551:215922. doi: 10.1016/j.canlet.2022.215922. Epub ahead of print. PMID: 36285687. 

 

Ding L, Tang S, Yu A, Wang A, Tang W, Jia H, Oupický D. Nanoemulsion-Assisted siRNA Delivery to Modulate the Nervous Tumor Microenvironment in the Treatment of Pancreatic Cancer. ACS Appl Mater Interfaces. 2022 Mar 2;14(8):10015-10029. doi: 10.1021/acsami.1c21997. Epub 2022 Feb 21. PMID: 35188730; PMCID: PMC9153289. 

 

Frodyma DE, Troia TC, Rao C, Svoboda RA, Berg JA, Shinde DD, Thomas VC, Lewis RE, Fisher KW. PGC-1β and ERRα Promote Glutamine Metabolism and Colorectal Cancer Survival via Transcriptional Upregulation of PCK2. Cancers (Basel). 2022 Oct 5;14(19):4879. doi: 10.3390/cancers14194879. PMID: 36230802; PMCID: PMC9562873. 

 

Khan R, Panja S, Ding L, Tang S, Tang W, Kapoor E, Bennett RG, Oupický D. Polymeric Chloroquine as an Effective Antimigration Agent in the Treatment of Pancreatic Cancer. Mol Pharm. 2022 Dec 5;19(12):4631-4643. doi: 10.1021/acs.molpharmaceut.2c00596. Epub 2022 Nov 8. PMID: 36346968. 

 

Laliwala A, Daverey A, Agrawal SK, Dash AK. Alpha Tocopherol Loaded Polymeric Nanoparticles: Preparation, Characterizations, and In Vitro Assessments Against Oxidative Stress in Spinal Cord Injury Treatment. AAPS PharmSciTech. 2022 Jul 13;23(6):195. doi: 10.1208/s12249-022-02345-2. PMID: 35831684. 

 

Ouellette SP, Fisher-Marvin LA, Harpring M, Lee J, Rucks EA, Cox JV. Localized cardiolipin synthesis is required for the assembly of MreB during the polarized cell division of Chlamydia trachomatis. PLoS Pathog. 2022 Sep 12;18(9):e1010836. doi: 10.1371/journal.ppat.1010836. PMID: 36095021; PMCID: PMC9499288. 

 

Pramanik S, Chen Y, Song H, Khutsishvili I, Marky LA, Ray S, Natarajan A, Singh PK, Bhakat KK. The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells. Nucleic Acids Res. 2022 Apr 8;50(6):3394-3412. doi: 10.1093/nar/gkac172. PMID: 35286386; PMCID: PMC8990529. 

 

Rajesh C, Sagar S, Rathinavel AK, Chemparathy DT, Peng XL, Yeh JJ, Hollingsworth MA, Radhakrishnan P. Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling. Int J Mol Sci. 2022 May 13;23(10):5459. doi: 10.3390/ijms23105459. PMID: 35628269; PMCID: PMC9141077. 

 

Tang S, Kapoor E, Ding L, Yu A, Tang W, Hang Y, Smith LM, Sil D, Oupický D. Effect of tocopherol conjugation on polycation-mediated siRNA delivery to orthotopic pancreatic tumors. Biomater Adv. 2022 Dec 6;145:213236. doi: 10.1016/j.bioadv.2022.213236. Epub ahead of print. PMID: 36512927. 

 

Tang W, Panja S, Jogdeo CM, Tang S, Ding L, Yu A, Foster KW, Dsouza DL, Chhonker YS, Jensen-Smith H, Jang HS, Boesen EI, Murry DJ, Padanilam B, Oupický D. Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury. Biomaterials. 2022 Jun;285:121562. doi: 10.1016/j.biomaterials.2022.121562. Epub 2022 May 2. PMID: 35552115; PMCID: PMC9133205. 

 

Tang W, Panja S, Jogdeo CM, Tang S, Yu A, Oupický D. Study of Renal Accumulation of Targeted Polycations in Acute Kidney Injury. Biomacromolecules. 2022 May 9;23(5):2064-2074. doi: 10.1021/acs.biomac.2c00079. Epub 2022 Apr 8. PMID: 35394757; PMCID: PMC9150723. 

 

Wang O, Han L, Lin H, Tian M, Zhang S, Duan B, Chung S, Zhang C, Lian X, Wang Y, Lei Y. Fabricating 3-dimensional human brown adipose microtissues for transplantation studies. Bioact Mater. 2022 Oct 27;22:518-534. doi: 10.1016/j.bioactmat.2022.10.022. PMID: 36330162; PMCID: PMC9619153. 

 

Wu S, Li Y, Zhang C, Tao L, Kuss M, Lim JY, Butcher J, Duan B. Tri-Layered and Gel-Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets. Adv Healthc Mater. 2022 May;11(10):e2200053. doi: 10.1002/adhm.202200053. Epub 2022 Mar 21. PMID: 35289986. 

 

Wu S, Qi Y, Shi W, Kuss M, Chen S, Duan B. Electrospun conductive nanofiber yarns for accelerating mesenchymal stem cells differentiation and maturation into Schwann cell-like cells under a combination of electrical stimulation and chemical induction. Acta Biomater. 2022 Feb;139:91-104. doi: 10.1016/j.actbio.2020.11.042. Epub 2020 Nov 30. PMID: 33271357; PMCID: PMC8164650. 

 

Xue W, Kong Y, Abu R, Roy P, Huh SH, Kuss M, Kumar V, Duan B. Regulation of Schwann Cell and DRG Neurite Behaviors within Decellularized Peripheral Nerve Matrix. ACS Appl Mater Interfaces. 2022 Feb 23;14(7):8693-8704. doi: 10.1021/acsami.1c20320. Epub 2022 Feb 11. PMID: 35148064. 

 

Yu A, Tang S, Ding L, Foley J, Tang W, Jia H, Panja S, Holbert CE, Hang Y, Stewart TM, Smith LM, Sil D, Casero RA Jr, Oupický D. Hyaluronate-coated perfluoroalkyl polyamine prodrugs as bioactive siRNA delivery systems for the treatment of peritoneal cancers. Biomater Adv. 2022 May;136:212755. doi: 10.1016/j.bioadv.2022.212755. Epub 2022 Mar 17. PMID: 35929290. 

 

Zhang C, Hang Y, Tang W, Sil D, Jensen-Smith HC, Bennett RG, McVicker BL, Oupický D. Dually Active Polycation/miRNA Nanoparticles for the Treatment of Fibrosis in Alcohol-Associated Liver Disease. Pharmaceutics. 2022 Mar 18;14(3):669. doi: 10.3390/pharmaceutics14030669. PMID: 35336043; PMCID: PMC8949580. 

 

Zhang D, Tu H, Hu W, Duan B, Zimmerman MC, Li YL. Hydrogen Peroxide Scavenging Restores N-Type Calcium Channels in Cardiac Vagal Postganglionic Neurons and Mitigates Myocardial Infarction-Evoked Ventricular Arrhythmias in Type 2 Diabetes Mellitus. Front Cardiovasc Med. 2022 Apr 25;9:871852. doi: 10.3389/fcvm.2022.871852. PMID: 35548411; PMCID: PMC9082497.