Richard A. Reinhardt, DDS, PhD | College of Dentistry | University of Nebraska Medical Center

Professor, Co-Director Undergraduate Periodontics

BJ & Ann Moran Professor of Periodontology
Surgical Specialties Department

Contact Information

Room 2170A, UNMC College of Dentistry
4000 East Campus Loop South
Lincoln, NE 68583-0740
402-472-1287
rareinha@unmc.edu

Education

DDS, UNMC College of Dentistry
MS, University of Nebraska-Lincoln
PhD, University of Nebraska-Omaha
Diplomate, American Board of Periodontology

Teaching Responsibilities

Director, PERIO 553 Periodontal Therapy
Co-Director, PERIO 629/630 Clinical Periodontics II
Co-Director, PERIO 696 Clinical Periodontics III
Director, PERIO 977M Prosthodontic & Periodontal Interrelationships
Director, PERIO 871 Advanced Periodontology

Research Interests

Immunoregulation of inflammation and bone metabolism
Effectiveness of periodontal maintenance therapy

Service Activities

Senior Dental Consultant, Ameritas Group, Lincoln, NE

Almoshari, Y., Ren, R., Zhang, H., Jia, Z., Wei, X., Chen, N., Li, G., Ryu, S., Lele, S.M., Reinhardt, R.A., Wang, D. GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis. Biomaterials 261:120293, 2020.
John, J.V., McCarthy, A., Wang, H., Chen, S., Su, Y., Davis, E., Li, X., Park, J.S., Reinhardt, R.A., Xie, J. Engineering biomimetic nanofiber microspheres with tailored size, predesigned structure, and desired composition via gas bubble-mediated coaxial electrospray. Small 16 (19):e1907393, 2020.
Boda, S.K., Wang, H., John, J.V., Reinhardt, R.A., Xie, J. Dual delivery of alendronate and E7-BMP-2 peptide. Almoshari, Y., Ren, R., Zhang, H., Jia, Z., Wei, X., Chen, N., Li, G., Ryu, S., Lele, S.M., Reinhardt, R.A., Wang, D. GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damag via calcium chelation to mineralized nanofiber fragments for alveolar bone regeneration. ACS Biomater Sci Eng 6(4):2368-2375, 2020.
Jasa, E.E., Gradoville, J.M., Christiansen, M.M., Samson, K.K., Reinhardt, R.A., Payne, J.B., Killeen, A.C. Effects of enamel matrix derivative on clinical and inflammatory outcomes in periodontal maintenance patients: randomized clinical trial. J Periodontol 91:1400-1408, 2020.
John, J.V., Choksi, M., Chen, S., Boda, S.K., Su, Y., McCarthy, A., Teusink, M.J., Reinhardt, R.A., Xie, J. Tethering peptides onto biomimetic and injectable nanofiber microspheres to direct cellular response. Nanomedicine 22:102081, 2019.
Liu, J., Chanumolu, S.K., Krei, Z., Albahrani, M., Akhtam, A., Jia, Z., Wang, X., Wang, D., Otu, H.H., Reinhardt, R.A., Nawshad, A. Identification of genes differentially expressed in simvastatin-induced alveolar bone formation. JBMR Plus 3(5):e10122, 2019.
Boda, S.K., Almoshari, Y., Wang, H., Wang, X., Reinhardt, R.A., Duan, B., Wang, D., Xie, J. Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration. Acta Biomater 85:282-293, 2019.
Cui, X., Monacelli, E., Killeen, A.C., Samson, K., Reinhardt, R.A. Impact of modifiable risk factors on bone loss during periodontal maintenance. Oper Dent 44:254-261, 2019.
Killeen, A.C., Harn, J.A., Jensen, J., Yu, F., Custer, S., Reinhardt, R.A. Two-year randomized clinical trial of adjunctive minocycline microspheres in periodontal maintenance. J Dent Hyg 92:51-58, 2018.
Wang, X., Jia, Z., Almoshari, Y., Lele, S.M., Reinhardt, R.A., Wang, D. Local application of pyrophosphorylated simvastatin prevents experimental periodontitis. Pharm Res 35:164, 2018.
Willett, E.S., Liu, J., Berke, M., Jia, Z., Wang, X., Samson, K., Yu, F., Wang, D., Nawshad, A., Reinhardt, R.A. Standardized rat model testing effects of inflammation and grafting on extraction healing. J Periodontol 88:799-807, 2017.
Killeen, A.C., Harn, J.A., Erickson, L.M., Yu, F., Reinhardt, R.A. Local minocycline effect on inflammation and clinical attachment during periodontal maintenance: randomized clinical trial. J Periodontol 87:1149-57, 2016.
Bradley, A.D., Zhang, Y., Jia, Z., Zhao, G., Wang, X., Pranke, L., Schmid, MD, Wang, D., Reinhardt, R.A. Effect of simvastatin prodrug on experimental periodontitis. J Periodontol 87:577-82, 2016.
Reinhardt, R.A., Killeen, A.C. Do mobility and occlusal trauma impact periodontal therapy? Dent Clin North Am 59:873-883, 2015.
Nguyen, N.T., Byarlay, M.R., Reinhardt, R.A., Marx, D.B., Meinbeg, T.A., Kaldahl, W.B. Adjunctive non-surgical therapy of inflamed periodontal pockets during maintenance therapy using diode laser: a randomized clinical trial. J Periodontol 86:1133-40, 2015.
Knudsen, M., Bury, M., Holwegner, C., Reinhardt, A.L., Yuan, F., Zhang, Y., Giannini, P., Marx, D.B., Wang, D., Reinhardt, R.A. Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats. Arthritis Res Ther 17:267,2015.
Holweger, C., Reinhardt, A.L., Schmid, M.J., Marx, D.B., Reinhardt, R.A. Impact of local steroid or statin treatment of experimental temporomandibular joint arthritis on bone growth in young rats. Am J Orthod Dentofacial Orthop 147:80-8, 2015
Chen, F., Jia, Z., Rice, K.C., Reinhardt, R.A., Bayles, K.W., Wang, D. The development of drug-free therapy for prevention of dental caries. Pharm Res 31:3031-7, 2014.
Zhang, Y., Bradley, A.D., Wang, D., Reinhardt, R.A. Statins, bone metabolism and treatment of bone catabolic diseases. Pharmacol Res 88:53-61, 2014.
Chen, F., Jia, Z., Rice, K.C., Reinhardt, R.A., Bayles, K.W., Wang, D. The development of dentotropic micelles with biodegradable tooth-binding moieties. Pharm Res 30:2808-2817, 2013.
George, MD, Owen, C.M., Reinhardt, A.L., Giannini, P.J., Marx, D.B., Reinhardt, R.A. Effect of simvastatin injections on temporomandibular joint inflammation in growing rats. J Oral Maxillofac Surg 71:846-853, 2013.
Price, U., Le, H.O., Powell, S.E., Schmid, M.J., Marx, D.B., Zhang, Y., Wang, D., Narayana, N., Reinhardt, R.A. Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss. J Periodontal Res 48:541-548, 2013.
Killeen, A.C., Rakes, PA, Schmid, M.J., Zhang, Y., Narayana, N., Marx, D.B., Payne, J.B., Wang, D., Reinhardt, R.A. Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects. J Periodontol 83: 1463-1471, 2012.
Lee, Y., Liu, X., Nawshad, A., Marx, D.B., Wang, D., Reinhardt, R.A. Role of prostaglandin pathway and alendronate-based carriers to enhance statin-induced bone. Mol Pharm 8:1015-1042, 2011.
Payne, J.B., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Reinhardt, R.A., Golub, L.M. & Serum bone biomarkers and oral/systemic bone loss in humans. J Dent Res 90:747-751, 2011.
Payne, J.B., Golub, L.M., Stoner, J.A., Lee, H.M., Reinhardt, R.A., Sorsa, T., Slepian, M.J. The effect of subantimicrobial-dose doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial J Am Dent Assoc 142:262-273, 2011.
Kador, P., O'Meara, J.D., Blessing, K., Marx, D.B., Reinhardt, R.A. Efficacy of structurally-diverse aldose reductase inhibitors on experimental periodontitis in rats. J Periodontol 82:926-933, 2011.
Rutledge, J., Schieber, MD, Chamberlain, J.M., Byarlay, M., Killeen, A.C., Giannini, P.J., Marx, D.B., Reinhardt, R.A. Simvastatin application to augment facial jaw bone in a dog model: pilot study J Periodontol 82:597-605, 2011.
Kador, P.F., Hamada, T., Reinhardt, R.A., Blessing, K. Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats. Postgrad Med 122:138-144, 2010.

August 2015 to December 2016 Tooth Extraction Model, Regenerative Medicine Pilot Project, Reinhardt, R.A.
August 2014 to July 2015 Tooth Extraction Model, Regenerative Medicine Pilot Project, Reinhardt, R.A.
July 2013 to April 2015 Prevention of Experimental Periodontitis in Rats with a Simvastatin Pro-drug, Surgical Specialties Postgraduate Research Fund/Summer Research Fellowship, Reinhardt, R.A., Bradley, A.D.
July 2012 to June 2015 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients, D.H. Reinhardt Scholar Fund, Killeen, A.C., Reinhardt, R.A.
April 2013 to April 2014 Dentotropic Pluronics as Novel Formulation Excipients for Oral Hygiene Products. IADR/GlaxoSmithKline Innovation in Oral Care Award: Wang,, D., Reinhardt, R.A.
July 2012 to December 2013 Treatment of Temporomandibular Joint Idiopathic Arthritis with Simvastatin versus Corticosteroid Therapy in Rats. Growth & Development Postgraduate Research Fund: Reinhardt, R.A., Owen, C.M.
July 2010 to June 2012 The Biochemical Effects of Simvastatin-Alendronate Combination on LPS-Induced Periodontitis. Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Le, H-O.
July 2010 to June 2012 The Effects of Simvastatin-Alendronate Combination in the Treatment of Experimentally-Induced Periodontitis in a Rat Model: Bone Loss Effects. Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Price, U.
June 2011 to December 2011 Treatment of Diabetic Periodontal Disease. American Diabetes Association: Kador, P., Reinhardt, R.A.
July 2010 to December 2011 Effect of Intra-articular Injection of Simvastatin on TMJ Inflammation. Growth & Development Postgraduate Research Fund: Reinhardt, R.A., George, M.
July 2009 to December 2010 Effects of Prophylactic versus Therapeutic Administration of Simvastatin on Alveolar Bone Loss in Endotoxin-Induced Periodontitis Utilizing a Rat Model. Growth & Development Postgraduate Research Fund: Reinhardt, R.A., Powell, S.
July 2009 to June 2011 Pharmaco-Manipulation of Statin-Induced Bone: Impact of Local and Systemic Alendronate Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Rakes, P.