Richard A. Reinhardt, DDS, PhD

Dr. Reinhardt

Professor, Co-Director Undergraduate Periodontics

BJ & Ann Moran Professor of Periodontology
Surgical Specialties Department

Contact Information

Room 2170A, UNMC College of Dentistry
4000 East Campus Loop South
Lincoln, NE 68583-0740
402-472-1287

Education

Teaching Responsibilities 
  • Director, PERIO 553 Periodontal Therapy
  • Co-Director, PERIO 629/630 Clinical Periodontics II
  • Co-Director, PERIO 696 Clinical Periodontics III
  • Director, PERIO 977M Prosthodontic & Periodontal Interrelationships
  • Director, PERIO 871 Advanced Periodontology
Research Interests 
  • Immunoregulation of inflammation and bone metabolism 
  • Effectiveness of periodontal maintenance therapy
Grants 
  • August 2015 to December 2016 Tooth Extraction Model, Regenerative Medicine Pilot Project, Reinhardt, R.A.
  • August 2014 to July 2015 Tooth Extraction Model, Regenerative Medicine Pilot Project, Reinhardt, R.A.
  • July 2013 to April 2015 Prevention of Experimental Periodontitis in Rats with a Simvastatin Pro-drug, Surgical Specialties Postgraduate Research Fund/Summer Research Fellowship, Reinhardt, R.A., Bradley, A.D.
  • July 2012 to June 2015 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients, D.H. Reinhardt Scholar Fund, Killeen, A.C., Reinhardt, R.A.
  • April 2013 to April 2014 Dentotropic Pluronics as Novel Formulation Excipients for Oral Hygiene Products. IADR/GlaxoSmithKline Innovation in Oral Care Award: Wang,, D., Reinhardt, R.A.
  • July 2012 to December 2013 Treatment of Temporomandibular Joint Idiopathic Arthritis with Simvastatin versus Corticosteroid Therapy in Rats. Growth & Development Postgraduate Research Fund: Reinhardt, R.A., Owen, C.M.
  • July 2010 to June 2012 The Biochemical Effects of Simvastatin-Alendronate Combination on LPS-Induced Periodontitis. Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Le, H-O.
  • July 2010 to June 2012 The Effects of Simvastatin-Alendronate Combination in the Treatment of Experimentally-Induced Periodontitis in a Rat Model: Bone Loss Effects. Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Price, U.
  • June 2011 to December 2011 Treatment of Diabetic Periodontal Disease. American Diabetes Association: Kador, P., Reinhardt, R.A.
  • July 2010 to December 2011 Effect of Intra-articular Injection of Simvastatin on TMJ Inflammation. Growth & Development Postgraduate Research Fund: Reinhardt, R.A., George, M.
  • July 2009 to December 2010 Effects of Prophylactic versus Therapeutic Administration of Simvastatin on Alveolar Bone Loss in Endotoxin-Induced Periodontitis Utilizing a Rat Model. Growth & Development Postgraduate Research Fund: Reinhardt, R.A., Powell, S.
  • July 2009 to June 2011 Pharmaco-Manipulation of Statin-Induced Bone: Impact of Local and Systemic Alendronate Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Rakes, P.
Selected Publications 
  • Almoshari, Y., Ren, R., Zhang, H., Jia, Z., Wei, X., Chen, N., Li, G., Ryu, S., Lele, S.M., Reinhardt, R.A., Wang, D. GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis. Biomaterials 261:120293, 2020.
  • John, J.V., McCarthy, A., Wang, H., Chen, S., Su, Y., Davis, E., Li, X., Park, J.S., Reinhardt, R.A., Xie, J. Engineering biomimetic nanofiber microspheres with tailored size, predesigned structure, and desired composition via gas bubble-mediated coaxial electrospray. Small 16 (19):e1907393, 2020.
  • Boda, S.K., Wang, H., John, J.V., Reinhardt, R.A., Xie, J. Dual delivery of alendronate and E7-BMP-2 peptideAlmoshari, Y., Ren, R., Zhang, H., Jia, Z., Wei, X., Chen, N., Li, G., Ryu, S., Lele, S.M., Reinhardt, R.A., Wang, D. GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damag via calcium chelation to mineralized nanofiber fragments for alveolar bone regeneration. ACS Biomater Sci Eng 6(4):2368-2375, 2020.
  • Jasa, E.E., Gradoville, J.M., Christiansen, M.M., Samson, K.K., Reinhardt, R.A., Payne, J.B., Killeen, A.C.  Effects of enamel matrix derivative on clinical and inflammatory outcomes in periodontal maintenance patients:  randomized clinical trial.  J Periodontol 91:1400-1408, 2020.  
  • John, J.V., Choksi, M., Chen, S., Boda, S.K., Su, Y., McCarthy, A., Teusink, M.J., Reinhardt, R.A., Xie, J. Tethering peptides onto biomimetic and injectable nanofiber microspheres to direct cellular response. Nanomedicine 22:102081, 2019.
  • Liu, J., Chanumolu, S.K., Krei, Z., Albahrani, M., Akhtam, A., Jia, Z., Wang, X., Wang, D., Otu,     H.H., Reinhardt, R.A., Nawshad, A. Identification of genes differentially expressed in simvastatin-induced alveolar bone formation. JBMR Plus 3(5):e10122, 2019.
  • Boda, S.K., Almoshari, Y., Wang, H., Wang, X., Reinhardt, R.A., Duan, B., Wang, D., Xie, J.             Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration. Acta Biomater 85:282-293, 2019.
  • Cui, X., Monacelli, E., Killeen, A.C., Samson, K., Reinhardt, R.A. Impact of modifiable risk factors on bone loss during periodontal maintenance. Oper Dent 44:254-261, 2019.
  • Killeen, A.C., Harn, J.A., Jensen, J., Yu, F., Custer, S., Reinhardt, R.A. Two-year randomized clinical trial of adjunctive minocycline microspheres in periodontal maintenance. J Dent Hyg 92:51-58, 2018.
  • Wang, X., Jia, Z., Almoshari, Y., Lele, S.M., Reinhardt, R.A., Wang, D. Local application of             pyrophosphorylated simvastatin prevents experimental periodontitis. Pharm Res 35:164, 2018.
  • Willett, E.S., Liu, J., Berke, M., Jia, Z., Wang, X., Samson, K., Yu, F., Wang, D., Nawshad, A., Reinhardt, R.A.  Standardized rat model testing effects of inflammation and grafting on extraction healing.  J Periodontol 88:799-807, 2017.
  • Killeen, A.C., Harn, J.A., Erickson, L.M., Yu, F., Reinhardt, R.A.  Local minocycline effect on inflammation and clinical attachment during periodontal maintenance: randomized clinical trial.  J Periodontol 87:1149-57, 2016. 
  • Bradley, A.D., Zhang, Y., Jia, Z., Zhao, G., Wang, X., Pranke, L., Schmid, MD, Wang, D., Reinhardt, R.A.  Effect of simvastatin prodrug on experimental periodontitis.  J Periodontol 87:577-82, 2016.
  • Reinhardt, R.A., Killeen, A.C.  Do mobility and occlusal trauma impact periodontal therapy?  Dent Clin North Am 59:873-883, 2015.
  • Nguyen, N.T., Byarlay, M.R., Reinhardt, R.A., Marx, D.B., Meinbeg, T.A., Kaldahl, W.B.  Adjunctive non-surgical therapy of inflamed periodontal pockets during maintenance therapy using diode laser: a randomized clinical trial.  J Periodontol 86:1133-40, 2015.
  • Knudsen, M., Bury, M., Holwegner, C., Reinhardt, A.L., Yuan, F., Zhang, Y., Giannini, P., Marx, D.B., Wang, D., Reinhardt, R.A.  Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats.  Arthritis Res Ther 17:267,2015.
  • Holweger, C., Reinhardt, A.L., Schmid, M.J., Marx, D.B., Reinhardt, R.A. Impact of local steroid or statin treatment of experimental temporomandibular joint arthritis on bone growth in young rats.  Am J Orthod Dentofacial Orthop 147:80-8, 2015
  • Chen, F., Jia, Z., Rice, K.C., Reinhardt, R.A., Bayles, K.W., Wang, D.  The development of drug-free therapy for prevention of dental caries.  Pharm Res 31:3031-7, 2014.
  • Zhang, Y., Bradley, A.D., Wang, D., Reinhardt, R.A. Statins, bone metabolism and treatment of bone catabolic diseases. Pharmacol Res 88:53-61, 2014.
  • Chen, F., Jia, Z., Rice, K.C., Reinhardt, R.A., Bayles, K.W., Wang, D. The development of dentotropic micelles with biodegradable tooth-binding moieties. Pharm Res 30:2808-2817, 2013.
  • George, MD, Owen, C.M., Reinhardt, A.L., Giannini, P.J., Marx, D.B., Reinhardt, R.A.  Effect of simvastatin injections on temporomandibular joint inflammation in growing rats.  J Oral Maxillofac Surg 71:846-853, 2013.
  • Price, U., Le, H.O., Powell, S.E., Schmid, M.J., Marx, D.B., Zhang, Y., Wang, D., Narayana, N., Reinhardt, R.A. Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss. J Periodontal Res 48:541-548, 2013.
  • Killeen, A.C., Rakes, PA, Schmid, M.J., Zhang, Y., Narayana, N., Marx, D.B., Payne, J.B., Wang, D., Reinhardt, R.A. Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects. J Periodontol 83: 1463-1471, 2012.
  • Lee, Y., Liu, X., Nawshad, A., Marx, D.B., Wang, D., Reinhardt, R.A. Role of prostaglandin pathway and alendronate-based carriers to enhance statin-induced bone. Mol Pharm 8:1015-1042, 2011.
  • Payne, J.B., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Reinhardt, R.A., Golub, L.M. & Serum bone biomarkers and oral/systemic bone loss in humans. J Dent Res 90:747-751, 2011.
  • Payne, J.B., Golub, L.M., Stoner, J.A., Lee, H.M., Reinhardt, R.A., Sorsa, T., Slepian, M.J. The effect of subantimicrobial-dose doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial J Am Dent Assoc 142:262-273, 2011.
  • Kador, P., O'Meara, J.D., Blessing, K., Marx, D.B., Reinhardt, R.A. Efficacy of structurally-diverse aldose reductase inhibitors on experimental periodontitis in rats. J Periodontol 82:926-933, 2011.
  • Rutledge, J., Schieber, MD, Chamberlain, J.M., Byarlay, M., Killeen, A.C., Giannini, P.J., Marx, D.B., Reinhardt, R.A. Simvastatin application to augment facial jaw bone in a dog model: pilot study J Periodontol 82:597-605, 2011.
  • Kador, P.F., Hamada, T., Reinhardt, R.A., Blessing, K. Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats. Postgrad Med 122:138-144, 2010.
Service Activities 
  • Senior Dental Consultant, Ameritas Group, Lincoln, NE