Department of Genetics, Cell Biology and Anatomy
985805 Nebraska Medical Center
Omaha, NE 68198-5805
PhD, Columbia University, 1988
Co-Director, COM Neurosciences Block
Honors & Awards:
Distinguished Scientist Award, University of Nebraska Medical Center, 2008
Alvin Earle Outstanding Health Science Educator Award, 2001
M1 Golden Apple Award, UNMC, 1997
Research Career Development Award (KO4), The National Institutes of Health, 1995
M1 Golden Apple Award, UNMC, 1995
Dr. Norgren's research is currently focused on the use of nonhuman primate genomics to better understand human genetic disease. Work in the Norgren Laboratory resulted in a novel approach to the production of the Rhesus Macaque GeneChip, a device for measuring the expression of tens of thousands of genes at the same time. You can read more about how the rhesus genechip was invented here: "Novel approach results in first-ever rhesus macaque whole-genome array". In collaboration with Aleksey Zimin and other researchers, a new assembly and annotation of the rhesus genome was recently completed. This work was highlighted in Genome Technology: 'The Other Primates'. For more information on current research in the Norgren Lab check out the Lab webpage.
- Ward, M. D., Brueggemann, E. E., Kenny, T., Reitstetter, R. E., Mahone, C. R., Trevino, S., Wetzel, K., Donnelly, G. C., Retterer, C., Norgren, R. B., Jr, Panchal, R. G., Warren, T. K., Bavari, S., & Cazares, L. H. (2019). Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison. Clinical proteomics, 16, 7.
- Palesch D., Bosinger S. E., Tharp G. K., Vanderford T. H., Paiardini M., Chahroudi A., Johnson Z. P., Kirchhoff F., Hahn B. H., Norgren R. B., Patel N. B., Sodora D. L., Dawoud R. A., Stewart C.-B., Seepo S. M., Harris R. A., Liu Y., Raveendran M., Han Y., English A.. Thomas G. W. C., Hahn M. W., Pipes L., Mason C. E., Muzny D. M., Gibbs R. A., Sauter D., Worley K., Rogers J., Silvestri G. (2018) Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host. Nature. 553: 77-81.
- Bimber B. N., Ramakrishnan R., Cervera-Juanes R., Madhira R., Peterson S. M., Norgren R. B., Ferguson B. (2017) Whole genome sequencing predicts novel human disease models in rhesus macaques. Genomics. pii: S0888-7543(17)30024-1.
- Gradnigo J. S., Majumdar A., Norgren R. B., and Moriyama E.N. (2016) Advantages of an improved rhesus macaque genome for evolutionary analyses. PLoS ONE 11: e0167376.
- Lockridge O., Norgren R. B., Johnson R. C., and Blake T. A. (2016) Naturally occurring genetic variants of human acetylcholinesterase and butyrylcholinesterase and their potential impact on the risk of toxicity from cholinesterase inhibitors. Chem Res Toxicol. 29:1381-92
- Cornish, A.S., Gibbs, R. M., and Norgren, R. B. (2016) Exome screening to identify loss-of-function mutations in the rhesus macaque for development of preclinical models of human disease. BMC Genomics, 17:170
- Maudhoo, M. D., Madison, J. D, and Norgren, R. B. (2015) De novo assembly of the chimpanzee transcriptome from NextGen mRNA sequences. GigaScience 4:18.
- Zimin, A. V., Cornish, A. S., Maudhoo, M.D., Gibbs, R. M. Zhang, X., Pandey, S., Meehan, D. T.,Wipfler, K., Bosinger, S. E., Johnson, Z. P., Tharp, G. K., Marcais, G., Roberts, M., Ferguson, B., Fox, H., Treangen, T., Salzberg, S. L., Yorke, J. A. and Norgren, R. B. (2014) A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Biology Direct, 9:20.
- Maudhoo, M. D., Ren, D., Gradnigo, J. S. Gibbs, R. M., Lubker, A. C., Moriyama, E. N., French, J. A. and Norgren, R. B. (2014) De novo assembly of the common marmoset transcriptome from NextGen mRNA sequences. GigaScience, 3:14.
- Sandler, N. G., Bosinger, S. E., Estes J. D., Zhu, R. T. R., Tharp, G. K., Boritz, E., Levin, D., Wijeyesinghe, S., Makamdop, K. N., Del Prete G. Q., Hill, B. J., Timmer, J. K., Reiss E., Darko, S., Contijoch, E., Todd, J. P., Silvestri, G., Nason, M., Norgren, R. B. , Keele, B. F., Rao, S., Langer, J. A., Lifson, J. D., Schreiber, G. and Douek, D. C. (2014) Type I IFN responses in rhesus macaques prevent SIV transmission and slow disease progression. Nature, 51: 601-605.
- Norgren, R. B. (2013) Improving genome assemblies and annotations for nonhuman primates. ILAR J. 54: 144-153.
- Zhang, X., Goodsell, J. and Norgren R. B. (2012) Limitations of the rhesus macaque draft genome assembly and annotation. BMC Genomics, 13:206
- Norgren, R. B. (2012) Using NextGen sequencing to identify the molecular basis for genetic disease: an evolutionary perspective. Methods in Next Generation Sequencing. 1: 1-9.
- Duan, F. Pauley, M. A., Spindel, E. R., Zhang, L. and Norgren R. B. (2010) Large scale analysis of positional effects of single-base mismatches on microarray gene expression data. BioData Mining, 3:2
- Meehan, D.T., Zink, M.A., Mahlen, M., Nelson, M., Sanger, W.G., Mitalipov, S.M., Wolf, D.P., Ouellettte, M.M.,Norgren, R.B. (2008) Gene targeting in adult rhesus macaque fibroblasts. BMC Biotechnol, 8:31.
- Duan, F., Spindel, E.R., Li, Y-H and Norgren, R.B. (2007) Intercenter reliability and validity of the rhesus macaque GeneChip. BMC Genomics, 8:61.
- Ferguson, B., Street, S.L., Wright, H., Pearson, C., Jia, Y., Thompson, S.L., Allibone, P., Dubay, C.J., Spindel, E. and Norgren, R.B. (2007) Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta). BMC Genomics, 8:44.
- Norgren, R.B. (2006) Expression arrays for macaque monkeys. Transplantation Reviews, 20: 115-120.
- Norgren, R.B. (2006) Genetic modification of somatic cells for producing animal models and re-engineering of cells for transplantation. Reproduction, Fertility and Development, 20: 115-120.
- Spindel, E.R., Pauley, M.A., Jia,Y., Gravett, C.,Thompson, S., Boyle, N., Ojeda, S.R., and Norgren, R.B. (2005)Leveraging human genomic information to identify nonhuman primate sequences for expression array development, BMC Genomics, 6:160.